| 621359 | Tnfaip6 | TNF alpha induced protein 6 | ENCODES a protein that exhibits calcium ion binding (ortholog); carboxylesterase activity (ortholog); fibronectin binding (ortholog); INVOLVED IN positive regulation of cell migration; fibronectin fibril organization (ortholog); hyaluronan metabolic process (ortholog); ASSOCIATED WITH Peritoneal Fib rosis; Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); FOUND IN extracellular space; extracellular region (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol | 3 | 56911398 | 56930797 | Rat | 270 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1345645 | TNFAIP6 | TNF alpha induced protein 6 | The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010] | 2 | 151357592 | 151381340 | Human | 273 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1615154 | Tnfaip6 | tumor necrosis factor alpha induced protein 6 | Predicted to enable several functions, including carboxylesterase activity; fibronectin binding activity; and hyaluronic acid binding activity. Involved in ovarian cumulus expansion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in corneal neovascularization. Orthologous to human TNFAIP6 (TNF alpha induced protein 6). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 51928125 | 51946693 | Mouse | 297 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8801097 | Tnfaip6 | TNF alpha induced protein 6 | ENCODES a protein that exhibits calcium ion binding (ortholog); carboxylesterase activity (ortholog); fibronectin binding (ortholog); INVOLVED IN fibronectin fibril organization (ortholog); hyaluronan metabolic process (ortholog); negative regulation of BMP signaling pathway (ortholog); ASSOCIATED W ITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); Arsenic Poisoning (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog) | NW_004955440 | 16915952 | 16944375 | Chinchilla | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11688337 | TNFAIP6 | TNF alpha induced protein 6 | ENCODES a protein that exhibits calcium ion binding (inferred); carboxylesterase activity (inferred); fibronectin binding (inferred); INVOLVED IN positive regulation of cell migration (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); Arsenic Poisoning (ortholog); FOUND IN extracellular space (ortholog) | 2B | 38669652 | 38692037 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12296115 | TNFAIP6 | TNF alpha induced protein 6 | ENCODES a protein that exhibits calcium ion binding (inferred); carboxylesterase activity (inferred); fibronectin binding (inferred); INVOLVED IN positive regulation of cell migration (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); Arsenic Poisoning (ortholog); FOUND IN extracellular space (ortholog) | 19 | 52607598 | 52623799 | Dog | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12503679 | Tnfaip6 | TNF alpha induced protein 6 | ENCODES a protein that exhibits calcium ion binding (inferred); carboxylesterase activity (inferred); fibronectin binding (inferred); INVOLVED IN positive regulation of cell migration (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); Arsenic Poisoning (ortholog); FOUND IN extracellular space (ortholog) | NW_004936469 | 26129339 | 26145464 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18420607 | TNFAIP6 | TNF alpha induced protein 6 | ENCODES a protein that exhibits calcium ion binding (inferred); carboxylesterase activity (inferred); fibronectin binding (inferred); INVOLVED IN positive regulation of cell migration (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); Arsenic Poisoning (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626122988 | Tnfaip6 | TNF alpha induced protein 6 | ENCODES a protein that exhibits calcium ion binding (ortholog); carboxylesterase activity (ortholog); fibronectin binding (ortholog); INVOLVED IN fibronectin fibril organization (ortholog); hyaluronan metabolic process (ortholog); negative regulation of BMP signaling pathway (ortholog); ASSOCIATED W ITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); Arsenic Poisoning (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog) | | | | Black Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18900210 | Tnfaip6 | TNF alpha induced protein 6 | ENCODES a protein that exhibits calcium ion binding (ortholog); carboxylesterase activity (ortholog); fibronectin binding (ortholog); INVOLVED IN fibronectin fibril organization (ortholog); hyaluronan metabolic process (ortholog); negative regulation of BMP signaling pathway (ortholog); ASSOCIATED W ITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); Arsenic Poisoning (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236761 | tnfaip6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14207585 | TNFAIP6 | TNF alpha induced protein 6 | ENCODES a protein that exhibits calcium ion binding (inferred); carboxylesterase activity (inferred); fibronectin binding (inferred); INVOLVED IN positive regulation of cell migration (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); Arsenic Poisoning (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH cadmium atom; chlorpyrifos; N-acetyl-L-cysteine | | | | Pig | 49 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155243526 | tnfaip6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247098 | tnfaip6.S | | | | | | African Clawed Frog | | symbol | gene, null |