| 1310993 | Tet1 | tet methylcytosine dioxygenase 1 | ENCODES a protein that exhibits DNA 5-methylcytosine dioxygenase activity (ortholog); DNA binding (ortholog); iron ion binding (ortholog); INVOLVED IN cellular response to reactive oxygen species (ortholog); chromatin remodeling (ortholog); dendrite morphogenesis (ortholog); PARTICIPATES IN DNA modi fication pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nuclear membrane (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil | 20 | 25766806 | 25839598 | Rat | 187 | symbol , old_gene_name , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1322209 | TET1 | tet methylcytosine dioxygenase 1 | DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015] | 10 | 68560337 | 68694487 | Human | 194 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1322210 | Tet1 | tet methylcytosine dioxygenase 1 | Enables DNA 5-methylcytosine dioxygenase activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including dendrite morphogenesis; inner cell mass cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within epigenetic programing of male pronucleus and positive regulation of gene expression via chromosomal CpG island demethylation. Located in nucleus. Is expressed in several structures, including brain; early conceptus; immune system; lower urogenital tract; and reproductive system. Orthologous to human TET1 (tet methylcytosine dioxygenase 1). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 62640349 | 62723242 | Mouse | 262 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8981198 | Tet1 | tet methylcytosine dioxygenase 1 | ENCODES a protein that exhibits DNA 5-methylcytosine dioxygenase activity (ortholog); DNA binding (ortholog); iron ion binding (ortholog); INVOLVED IN cellular response to reactive oxygen species (ortholog); chromatin remodeling (ortholog); dendrite morphogenesis (ortholog); PARTICIPATES IN DNA modi fication pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nuclear membrane (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955425 | 20767406 | 20857165 | Chinchilla | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11931571 | TET1 | tet methylcytosine dioxygenase 1 | ENCODES a protein that exhibits 2-oxoglutarate-dependent dioxygenase activity (inferred); dioxygenase activity (inferred); DNA 5-methylcytosine dioxygenase activity (inferred); INVOLVED IN dendrite morphogenesis (ortholog); epigenetic programing of male pronucleus (ortholog); inner cell mass cell di fferentiation (ortholog); PARTICIPATES IN DNA modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); hepatocellular carcinoma (ortholog); FOUND IN chromosome (inferred); nuclear membrane (inferred); nucleoplasm (inferred) | 10 | 65036313 | 65168051 | Bonobo | 48 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12294352 | TET1 | tet methylcytosine dioxygenase 1 | ENCODES a protein that exhibits 2-oxoglutarate-dependent dioxygenase activity (inferred); dioxygenase activity (inferred); DNA 5-methylcytosine dioxygenase activity (inferred); INVOLVED IN dendrite morphogenesis (ortholog); epigenetic programing of male pronucleus (ortholog); inner cell mass cell di fferentiation (ortholog); PARTICIPATES IN DNA modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); hepatocellular carcinoma (ortholog); FOUND IN chromosome (inferred); nuclear membrane (inferred); nucleoplasm (inferred) | 4 | 19759661 | 19898345 | Dog | 48 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18363277 | TET1 | tet methylcytosine dioxygenase 1 | ENCODES a protein that exhibits 2-oxoglutarate-dependent dioxygenase activity (inferred); dioxygenase activity (inferred); DNA 5-methylcytosine dioxygenase activity (inferred); INVOLVED IN dendrite morphogenesis (ortholog); epigenetic programing of male pronucleus (ortholog); inner cell mass cell di fferentiation (ortholog); PARTICIPATES IN DNA modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); hepatocellular carcinoma (ortholog); FOUND IN chromosome (inferred); nuclear membrane (inferred); nucleoplasm (inferred) | | | | Green Monkey | 48 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626053418 | Tet1 | tet methylcytosine dioxygenase 1 | ENCODES a protein that exhibits DNA 5-methylcytosine dioxygenase activity (ortholog); DNA binding (ortholog); iron ion binding (ortholog); INVOLVED IN cellular response to reactive oxygen species (ortholog); chromatin remodeling (ortholog); dendrite morphogenesis (ortholog); PARTICIPATES IN DNA modi fication pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nuclear membrane (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18930273 | Tet1 | tet methylcytosine dioxygenase 1 | ENCODES a protein that exhibits iron ion binding (ortholog); methyl-CpG binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to reactive oxygen species (ortholog); chromatin remodeling (ortholog); dendrite morphogenesis ( ortholog); PARTICIPATES IN DNA modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nuclear membrane (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 47 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14205451 | TET1 | tet methylcytosine dioxygenase 1 | ENCODES a protein that exhibits 2-oxoglutarate-dependent dioxygenase activity (inferred); dioxygenase activity (inferred); DNA 5-methylcytosine dioxygenase activity (inferred); INVOLVED IN dendrite morphogenesis (ortholog); epigenetic programing of male pronucleus (ortholog); inner cell mass cell di fferentiation (ortholog); PARTICIPATES IN DNA modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); hepatocellular carcinoma (ortholog); FOUND IN chromosome (inferred); nuclear membrane (inferred); nucleoplasm (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 49 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12612440 | LOC101960775 | cell division cycle and apoptosis regulator protein 1 | ENCODES a protein that exhibits 2-oxoglutarate-dependent dioxygenase activity (inferred); dioxygenase activity (inferred); DNA 5-methylcytosine dioxygenase activity (inferred); INVOLVED IN positive regulation of apoptotic process (ortholog); FOUND IN chromosome (inferred); Golgi apparatus (inferred) ; nuclear envelope lumen (inferred) | NW_004936521 | 9573918 | 9624469 | Squirrel | 56 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1347719 | KMT2A | lysine methyltransferase 2A | This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010] | 11 | 118436492 | 118526832 | Human | 556 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 18917007 | LOC101713655 | methylcytosine dioxygenase TET1-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18929890 | LOC101713699 | methylcytosine dioxygenase TET1-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18361614 | LOC103214873 | methylcytosine dioxygenase TET1-like | | | | | Green Monkey | | name | gene, pseudo, MODEL [RefSeq] |
| 18925295 | LOC106009793 | methylcytosine dioxygenase TET1-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 329345211 | LOC129392942 | methylcytosine dioxygenase TET1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 16562726 | AL513534.2 | novel transcript, overlapping to TET1 | | | | | Human | | name | gene, lncrna |
| 18934150 | LOC110347724 | methylcytosine dioxygenase TET1 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 1626694 | TET1P1 | tet methylcytosine dioxygenase 1 pseudogene 1 | | 13 | 87889943 | 87893597 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |