TET1 (tet methylcytosine dioxygenase 1) - Rat Genome Database

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Gene: TET1 (tet methylcytosine dioxygenase 1) Canis lupus familiaris
Analyze
Symbol: TET1
Name: tet methylcytosine dioxygenase 1
RGD ID: 12294352
Description: ENCODES a protein that exhibits 5-methylcytosine dioxygenase activity (inferred); dioxygenase activity (inferred); DNA binding (inferred); INVOLVED IN epigenetic programing of male pronucleus (ortholog); inner cell mass cell differentiation (ortholog); positive regulation of gene expression via chromosomal CpG island demethylation (ortholog); PARTICIPATES IN DNA modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); hepatocellular carcinoma (ortholog); FOUND IN chromosome (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CXXC finger 6; CXXC6; methylcytosine dioxygenase TET1; tet oncogene 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,759,661 - 19,898,345 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,768,137 - 19,889,907 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,891,023 - 20,029,547 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0420,031,603 - 20,170,708 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl420,040,122 - 20,165,077 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1419,932,890 - 20,071,946 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0420,135,757 - 20,275,156 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0420,478,282 - 20,617,403 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TET1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,759,661 - 19,898,345 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,768,137 - 19,889,907 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,891,023 - 20,029,547 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0420,031,603 - 20,170,708 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl420,040,122 - 20,165,077 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1419,932,890 - 20,071,946 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0420,135,757 - 20,275,156 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0420,478,282 - 20,617,403 (+)NCBIUU_Cfam_GSD_1.0
TET1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381068,560,337 - 68,694,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1068,560,337 - 68,694,487 (+)EnsemblGRCh38hg38GRCh38
GRCh371070,320,094 - 70,454,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,990,123 - 70,124,245 (+)NCBINCBI36Build 36hg18NCBI36
Build 341069,990,418 - 70,123,454NCBI
Celera1063,596,035 - 63,730,160 (+)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1064,321,678 - 64,456,326 (+)NCBIHuRef
CHM1_11070,602,173 - 70,737,025 (+)NCBICHM1_1
T2T-CHM13v2.01069,429,559 - 69,563,685 (+)NCBIT2T-CHM13v2.0
Tet1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,640,349 - 62,723,242 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1062,640,349 - 62,744,775 (-)EnsemblGRCm39 Ensembl
GRCm381062,804,570 - 62,887,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,804,570 - 62,908,996 (-)EnsemblGRCm38mm10GRCm38
MGSCv371062,267,318 - 62,342,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361062,207,059 - 62,275,371 (-)NCBIMGSCv36mm8
Celera1063,905,755 - 63,981,217 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.48NCBI
Tet1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,766,806 - 25,839,598 (+)NCBIGRCr8
mRatBN7.22025,761,042 - 25,840,926 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,768,120 - 25,833,052 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02027,359,122 - 27,438,039 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2027,366,213 - 27,437,427 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02029,200,519 - 29,267,971 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,131,169 - 25,155,785 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,145,587 - 25,220,858 (-)NCBI
Celera2027,057,215 - 27,136,909 (+)NCBICelera
Cytogenetic Map20q11NCBI
Tet1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542520,767,406 - 20,857,165 (+)NCBIChiLan1.0ChiLan1.0
TET1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2880,712,893 - 80,853,460 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11080,718,227 - 80,858,781 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01065,036,313 - 65,168,051 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11067,575,157 - 67,705,834 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1067,586,586 - 67,703,160 (+)Ensemblpanpan1.1panPan2
TET1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1471,675,671 - 71,815,618 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11471,675,671 - 71,812,732 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,728,167 - 77,830,058 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TET1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1962,709,800 - 62,843,322 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl962,712,484 - 62,837,138 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604823,461,866 - 23,597,039 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tet1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247542,873,456 - 2,965,097 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247542,846,479 - 2,966,845 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TET1
1320 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000043209   ⟹   ENSCAFP00000038827
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl419,768,137 - 19,889,907 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845004339   ⟹   ENSCAFP00845003464
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl420,040,122 - 20,165,077 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845004362   ⟹   ENSCAFP00845003484
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl420,040,122 - 20,165,077 (+)Ensembl
RefSeq Acc Id: XM_022417496   ⟹   XP_022273204
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1419,759,661 - 19,898,345 (+)NCBI
Dog10K_Boxer_Tasha419,891,023 - 20,029,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038473096   ⟹   XP_038329024
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1419,932,890 - 20,071,946 (+)NCBI
RefSeq Acc Id: XM_038534146   ⟹   XP_038390074
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0420,478,282 - 20,617,403 (+)NCBI
RefSeq Acc Id: XM_038598462   ⟹   XP_038454390
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0420,135,757 - 20,275,156 (+)NCBI
RefSeq Acc Id: XM_038662765   ⟹   XP_038518693
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0420,031,603 - 20,170,708 (+)NCBI
RefSeq Acc Id: XP_022273204   ⟸   XM_022417496
- UniProtKB: A0A8C0NNN7 (UniProtKB/TrEMBL),   A0A8P0STB2 (UniProtKB/TrEMBL),   A0A8P0PLS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000038827   ⟸   ENSCAFT00000043209
RefSeq Acc Id: XP_038329024   ⟸   XM_038473096
RefSeq Acc Id: XP_038454390   ⟸   XM_038598462
RefSeq Acc Id: XP_038518693   ⟸   XM_038662765
- UniProtKB: A0A8I3MT69 (UniProtKB/TrEMBL),   A0A8I3N276 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390074   ⟸   XM_038534146
- UniProtKB: A0A8C0PXL6 (UniProtKB/TrEMBL),   A0A8I3N276 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845003464   ⟸   ENSCAFT00845004339
Ensembl Acc Id: ENSCAFP00845003484   ⟸   ENSCAFT00845004362
Protein Domains
CXXC-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013739 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018094 UniProtKB/TrEMBL
  ENSCAFG00040003225 UniProtKB/TrEMBL
  ENSCAFG00845002465 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000043209.4 UniProtKB/TrEMBL
  ENSCAFT00000108075.1 UniProtKB/TrEMBL
  ENSCAFT00030033341.1 UniProtKB/TrEMBL
  ENSCAFT00040006105.1 UniProtKB/TrEMBL
  ENSCAFT00845004339 ENTREZGENE
  ENSCAFT00845004339.1 UniProtKB/TrEMBL
  ENSCAFT00845004362.1 UniProtKB/TrEMBL
InterPro 2OGFeDO_noxygenase_dom UniProtKB/TrEMBL
  TET1/2/3 UniProtKB/TrEMBL
  TET_oxygenase UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/TrEMBL
NCBI Gene TET1 ENTREZGENE
PANTHER METHYLCYTOSINE DIOXYGENASE TET1 UniProtKB/TrEMBL
  PTHR23358 UniProtKB/TrEMBL
Pfam Tet_JBP UniProtKB/TrEMBL
  zf-CXXC UniProtKB/TrEMBL
PROSITE ZF_CXXC UniProtKB/TrEMBL
SMART Tet_JBP UniProtKB/TrEMBL
UniProt A0A8C0NNN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PXL6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MT69 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N276 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PLS0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0STB2 ENTREZGENE
UniProt Secondary A0A8P0STB2 UniProtKB/TrEMBL
VGNC ID VGNC:47260 ENTREZGENE