| 1306748 | Tal1 | TAL bHLH transcription factor 1, erythroid differentiation factor | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); astrocyte fate commitment (ortholog); basophil differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (or tholog); lymphoid leukemia (ortholog); T-cell acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A | 5 | 133823093 | 133837737 | Rat | 162 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1315543 | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor | Enables several functions, including E-box binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and histone deacetylase binding activity. Involved in several processes, including myeloid cell differentiation; positive regulation of cellular component organi zation; and positive regulation of erythrocyte differentiation. Located in chromatin and nucleoplasm. Part of transcription regulator complex. Implicated in acute lymphoblastic leukemia. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 47216290 | 47232335 | Human | 162 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1315544 | Tal1 | T cell acute lymphocytic leukemia 1 | Enables DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Contributes to DNA binding activity. Involved in embryonic hemopoiesis; positive regulation of erythrocyte differentiation; and regulation of transcription by RNA po lymerase II. Acts upstream of with a positive effect on transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; hemolymphoid system; and sensory organ. Used to study lymphoid leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 114913623 | 114928952 | Mouse | 268 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8786141 | Tal1 | TAL bHLH transcription factor 1, erythroid differentiation factor | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); astrocyte fate commitment (ortholog); basophil differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (or tholog); lymphoid leukemia (ortholog); T-cell acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955464 | 11304611 | 11317420 | Chinchilla | 95 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11908988 | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN angiogenesis (ortholog); astrocyte fate commitment (ortholog); cell fate commitment (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (orthol og); lymphoid leukemia (ortholog); T-cell acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (inferred); nucleoplasm (inferred); nucleus (inferred) | 1 | 46524484 | 46540595 | Bonobo | 95 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12065841 | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN angiogenesis (ortholog); astrocyte fate commitment (ortholog); cell fate commitment (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (orthol og); lymphoid leukemia (ortholog); T-cell acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (inferred); nucleoplasm (inferred); nucleus (inferred) | 15 | 13446752 | 13462038 | Dog | 95 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12574612 | Tal1 | TAL bHLH transcription factor 1, erythroid differentiation factor | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN angiogenesis (ortholog); astrocyte fate commitment (ortholog); cell fate commitment (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (orthol og); lymphoid leukemia (ortholog); T-cell acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936474 | 28049326 | 28061495 | Squirrel | 95 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239427 | tal1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626166699 | Tal1 | TAL bHLH transcription factor 1, erythroid differentiation factor | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); astrocyte fate commitment (ortholog); basophil differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (or tholog); lymphoid leukemia (ortholog); T-cell acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 95 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14169226 | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN angiogenesis (ortholog); astrocyte fate commitment (ortholog); cell fate commitment (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (orthol og); lymphoid leukemia (ortholog); T-cell acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (inferred); nucleoplasm (inferred); nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 96 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14388731 | TAL1 | | | | | | Yeast | | symbol | gene, null |
| 18491978 | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN angiogenesis (ortholog); astrocyte fate commitment (ortholog); cell fate commitment (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (orthol og); lymphoid leukemia (ortholog); T-cell acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 95 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930685 | Tal1 | TAL bHLH transcription factor 1, erythroid differentiation factor | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); astrocyte fate commitment (ortholog); basophil differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (or tholog); lymphoid leukemia (ortholog); T-cell acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Naked Mole-Rat | 99 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253166 | tal1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239960 | tal1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1312721 | Stil | Scl/Tal1 interrupting locus | This gene encodes a centrosomal protein ubiquitously expressed in proliferating cells and during early embryonic development. Mice lacking the encoded protein die in utero with marked growth retardation, defects in the developing neural fold and randomization of left-right asymmetry. Alternative spl icing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015] | 4 | 114857287 | 114900404 | Mouse | 154 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1304972 | Stil | STIL, centriolar assembly protein | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN centrosome duplication (ortholog); determination of left/right symmetry (ortholog); embryonic axis specification (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic dise ase (ortholog); intellectual disability (ortholog); FOUND IN centriole (ortholog); centrosome (ortholog); ciliary basal body (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 133757598 | 133810493 | Rat | 138 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1312720 | STIL | STIL centriolar assembly protein | This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in respo nse to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 1 | 47250139 | 47314896 | Human | 297 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 8922790 | Stil | STIL centriolar assembly protein | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN centrosome duplication (ortholog); determination of left/right symmetry (ortholog); embryonic axis specification (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic dise ase (ortholog); intellectual disability (ortholog); FOUND IN centriole (ortholog); centrosome (ortholog); ciliary basal body (ortholog) | NW_004955464 | 11213265 | 11288648 | Chinchilla | 40 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12028471 | STIL | STIL centriolar assembly protein | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN centrosome duplication (ortholog); determination of left/right symmetry (ortholog); embryonic axis specification (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic dise ase (ortholog); intellectual disability (ortholog); FOUND IN centriole (inferred); centrosome (inferred); ciliary basal body (inferred) | 1 | 46551592 | 46639668 | Bonobo | 45 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12059087 | STIL | STIL centriolar assembly protein | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN centrosome duplication (ortholog); determination of left/right symmetry (ortholog); embryonic axis specification (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic dise ase (ortholog); intellectual disability (ortholog); FOUND IN centriole (inferred); centrosome (inferred); ciliary basal body (inferred) | 15 | 13369292 | 13431677 | Dog | 45 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12491683 | Stil | STIL centriolar assembly protein | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN centrosome duplication (ortholog); determination of left/right symmetry (ortholog); embryonic axis specification (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic dise ase (ortholog); intellectual disability (ortholog); FOUND IN centriole (inferred); centrosome (inferred); ciliary basal body (inferred) | NW_004936474 | 28079114 | 28131214 | Squirrel | 45 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13942481 | STIL | STIL centriolar assembly protein | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN centrosome duplication (ortholog); determination of left/right symmetry (ortholog); embryonic axis specification (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic dise ase (ortholog); intellectual disability (ortholog); FOUND IN centriole (inferred); centrosome (inferred); ciliary basal body (inferred) | | | | Pig | 45 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18931456 | Stil | STIL centriolar assembly protein | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN centrosome duplication (ortholog); determination of left/right symmetry (ortholog); embryonic axis specification (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic dise ase (ortholog); intellectual disability (ortholog); FOUND IN centriole (ortholog); centrosome (ortholog); ciliary basal body (ortholog) | | | | Naked Mole-Rat | 45 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18380367 | STIL | STIL centriolar assembly protein | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN centrosome duplication (ortholog); determination of left/right symmetry (ortholog); embryonic axis specification (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic dise ase (ortholog); intellectual disability (ortholog); FOUND IN centriole (inferred); centrosome (inferred); ciliary basal body (inferred) | | | | Green Monkey | 45 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1351937 | GIMAP4 | GTPase, IMAP family member 4 | This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1 ). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008] | 7 | 150567390 | 150573953 | Human | 69 | description | gene, protein-coding, REVIEWED [RefSeq] |