Tal1 (TAL bHLH transcription factor 1, erythroid differentiation factor) - Rat Genome Database

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Gene: Tal1 (TAL bHLH transcription factor 1, erythroid differentiation factor) Ictidomys tridecemlineatus
Analyze
Symbol: Tal1
Name: TAL bHLH transcription factor 1, erythroid differentiation factor
RGD ID: 12574612
Description: ENCODES a protein that exhibits DNA binding (ortholog); INVOLVED IN angiogenesis (ortholog); astrocyte fate commitment (ortholog); cell fate commitment (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); genetic disease (ortholog); T-cell acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: T-cell acute lymphocytic leukemia protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505862,223,080 - 62,238,124 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647428,047,808 - 28,056,065 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647428,049,326 - 28,061,495 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
astrocyte fate commitment  (IEA,ISO)
basophil differentiation  (IEA)
cell fate commitment  (IEA,ISO)
central nervous system neuron differentiation  (IEA,ISO)
definitive hemopoiesis  (IEA,ISO)
embryonic hemopoiesis  (IEA,ISO)
erythrocyte differentiation  (IEA,ISO)
erythrocyte maturation  (IEA,ISO)
generation of neurons  (IEA,ISO)
hemangioblast cell differentiation  (IEA,ISO)
hematopoietic stem cell differentiation  (IEA,ISO)
hemopoiesis  (IEA,ISO)
locomotory behavior  (IEA,ISO)
megakaryocyte development  (IEA,ISO)
megakaryocyte differentiation  (IEA,ISO)
myeloid cell differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
platelet formation  (IEA,ISO)
positive regulation of cell division  (IEA)
positive regulation of chromatin organization  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of erythrocyte differentiation  (IEA)
positive regulation of mitotic cell cycle  (IEA)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of mast cell differentiation  (IEA,ISO)
regulation of myeloid cell differentiation  (IEA,ISO)
regulation of somatic stem cell population maintenance  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
spinal cord association neuron differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tal1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505862,223,080 - 62,238,124 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647428,047,808 - 28,056,065 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647428,049,326 - 28,061,495 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38147,216,290 - 47,232,335 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl147,216,290 - 47,232,225 (-)EnsemblGRCh38hg38GRCh38
GRCh37147,681,962 - 47,698,007 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,454,551 - 47,468,030 (-)NCBINCBI36Build 36hg18NCBI36
Build 34147,393,983 - 47,407,463NCBI
Celera145,968,230 - 45,981,708 (-)NCBICelera
Cytogenetic Map1p33NCBI
HuRef145,798,600 - 45,812,074 (-)NCBIHuRef
CHM1_1147,798,845 - 47,812,319 (-)NCBICHM1_1
T2T-CHM13v2.0147,094,699 - 47,110,742 (-)NCBIT2T-CHM13v2.0
Tal1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394114,913,623 - 114,928,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4114,913,623 - 114,928,952 (+)EnsemblGRCm39 Ensembl
GRCm384115,056,426 - 115,071,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4115,056,426 - 115,071,755 (+)EnsemblGRCm38mm10GRCm38
MGSCv374114,732,132 - 114,744,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364114,557,459 - 114,569,687 (+)NCBIMGSCv36mm8
Celera4113,806,727 - 113,818,916 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map452.73NCBI
Tal1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85133,823,093 - 133,837,737 (+)NCBIGRCr8
mRatBN7.25128,586,776 - 128,600,976 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5128,587,701 - 128,600,976 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5131,270,143 - 131,283,468 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05132,999,788 - 133,013,121 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,021,481 - 133,034,804 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05133,864,401 - 133,878,604 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5133,864,798 - 133,878,830 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05137,655,978 - 137,670,144 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45135,430,985 - 135,444,692 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15135,438,330 - 135,447,104 (+)NCBI
Celera5127,232,703 - 127,245,971 (+)NCBICelera
Cytogenetic Map5q35NCBI
Tal1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546411,310,628 - 11,315,924 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546411,304,611 - 11,317,420 (+)NCBIChiLan1.0ChiLan1.0
TAL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21179,570,869 - 179,586,982 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11178,712,653 - 178,728,777 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0146,524,484 - 46,540,595 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1148,039,155 - 48,054,021 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl148,042,594 - 48,048,622 (-)Ensemblpanpan1.1panPan2
TAL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11513,446,752 - 13,462,038 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1513,449,481 - 13,462,047 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1513,598,407 - 13,614,022 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01513,595,386 - 13,611,008 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1513,598,590 - 13,611,010 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,395,087 - 13,410,685 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01513,463,077 - 13,478,696 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01513,532,579 - 13,548,206 (+)NCBIUU_Cfam_GSD_1.0
TAL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6164,283,366 - 164,295,290 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16164,282,242 - 164,297,636 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26151,830,187 - 151,846,169 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12085,681,247 - 85,697,887 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2085,688,155 - 85,694,829 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603331,381,681 - 31,398,704 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tal1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248595,586,977 - 5,601,460 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248595,586,489 - 5,601,225 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000008400   ⟹   ENSSTOP00000007528
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647428,047,808 - 28,056,065 (-)Ensembl
RefSeq Acc Id: XM_040288621   ⟹   XP_040144555
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505862,223,088 - 62,235,830 (-)NCBI
RefSeq Acc Id: XM_040288622   ⟹   XP_040144556
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505862,223,080 - 62,236,752 (-)NCBI
RefSeq Acc Id: XM_040288623   ⟹   XP_040144557
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505862,223,088 - 62,236,559 (-)NCBI
RefSeq Acc Id: XM_040288624   ⟹   XP_040144558
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505862,223,080 - 62,236,752 (-)NCBI
RefSeq Acc Id: XM_040288625   ⟹   XP_040144559
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505862,223,080 - 62,237,661 (-)NCBI
RefSeq Acc Id: XM_040288626   ⟹   XP_040144560
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505862,223,080 - 62,237,567 (-)NCBI
RefSeq Acc Id: XM_040288627   ⟹   XP_040144561
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505862,223,080 - 62,238,124 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_040144561   ⟸   XM_040288627
- UniProtKB: I3MBK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144559   ⟸   XM_040288625
- UniProtKB: I3MBK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144560   ⟸   XM_040288626
- UniProtKB: I3MBK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144558   ⟸   XM_040288624
- UniProtKB: I3MBK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144556   ⟸   XM_040288622
- UniProtKB: I3MBK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144557   ⟸   XM_040288623
- UniProtKB: I3MBK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144555   ⟸   XM_040288621
- UniProtKB: I3MBK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000007528   ⟸   ENSSTOT00000008400
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008396 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008400.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  TAL-like UniProtKB/TrEMBL
NCBI Gene Tal1 ENTREZGENE
PANTHER PTHR13864 UniProtKB/TrEMBL
  T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt I3MBK4 ENTREZGENE, UniProtKB/TrEMBL