TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor) - Rat Genome Database

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Gene: TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor) Pan paniscus
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Symbol: TAL1
Name: TAL bHLH transcription factor 1, erythroid differentiation factor
RGD ID: 11908988
Description: ENCODES a protein that exhibits DNA binding (ortholog); INVOLVED IN angiogenesis (ortholog); astrocyte fate commitment (ortholog); cell fate commitment (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); lymphoid leukemia (ortholog); T-cell acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: T-cell acute lymphocytic leukemia protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21179,570,869 - 179,586,982 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11178,712,653 - 178,728,777 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0146,524,484 - 46,540,595 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1148,039,155 - 48,054,021 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl148,042,594 - 48,048,622 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
astrocyte fate commitment  (IEA,ISO)
basophil differentiation  (IEA)
cell fate commitment  (IEA,ISO)
central nervous system neuron differentiation  (IEA,ISO)
definitive hemopoiesis  (IEA,ISO)
embryonic hemopoiesis  (IEA,ISO)
erythrocyte differentiation  (IEA,ISO)
erythrocyte maturation  (IEA,ISO)
generation of neurons  (IEA,ISO)
hemangioblast cell differentiation  (IEA,ISO)
hematopoietic stem cell differentiation  (IEA,ISO)
hemopoiesis  (IEA,ISO)
locomotory behavior  (IEA,ISO)
megakaryocyte development  (IEA,ISO)
megakaryocyte differentiation  (IEA,ISO)
myeloid cell differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
platelet formation  (IEA,ISO)
positive regulation of cell division  (IEA)
positive regulation of chromatin organization  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of erythrocyte differentiation  (IEA)
positive regulation of mitotic cell cycle  (IEA)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of mast cell differentiation  (IEA,ISO)
regulation of myeloid cell differentiation  (IEA,ISO)
regulation of somatic stem cell population maintenance  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
spinal cord association neuron differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TAL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21179,570,869 - 179,586,982 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11178,712,653 - 178,728,777 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0146,524,484 - 46,540,595 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1148,039,155 - 48,054,021 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl148,042,594 - 48,048,622 (-)Ensemblpanpan1.1panPan2
TAL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38147,216,290 - 47,232,335 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl147,216,290 - 47,232,225 (-)EnsemblGRCh38hg38GRCh38
GRCh37147,681,962 - 47,698,007 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,454,551 - 47,468,030 (-)NCBINCBI36Build 36hg18NCBI36
Build 34147,393,983 - 47,407,463NCBI
Celera145,968,230 - 45,981,708 (-)NCBICelera
Cytogenetic Map1p33NCBI
HuRef145,798,600 - 45,812,074 (-)NCBIHuRef
CHM1_1147,798,845 - 47,812,319 (-)NCBICHM1_1
T2T-CHM13v2.0147,094,699 - 47,110,742 (-)NCBIT2T-CHM13v2.0
Tal1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394114,913,623 - 114,928,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4114,913,623 - 114,928,952 (+)EnsemblGRCm39 Ensembl
GRCm384115,056,426 - 115,071,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4115,056,426 - 115,071,755 (+)EnsemblGRCm38mm10GRCm38
MGSCv374114,732,132 - 114,744,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364114,557,459 - 114,569,687 (+)NCBIMGSCv36mm8
Celera4113,806,727 - 113,818,916 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map452.73NCBI
Tal1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85133,823,093 - 133,837,737 (+)NCBIGRCr8
mRatBN7.25128,586,776 - 128,600,976 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5128,587,701 - 128,600,976 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5131,270,143 - 131,283,468 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05132,999,788 - 133,013,121 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,021,481 - 133,034,804 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05133,864,401 - 133,878,604 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5133,864,798 - 133,878,830 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05137,655,978 - 137,670,144 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45135,430,985 - 135,444,692 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15135,438,330 - 135,447,104 (+)NCBI
Celera5127,232,703 - 127,245,971 (+)NCBICelera
Cytogenetic Map5q35NCBI
Tal1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546411,310,628 - 11,315,924 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546411,304,611 - 11,317,420 (+)NCBIChiLan1.0ChiLan1.0
TAL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11513,446,752 - 13,462,038 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1513,449,481 - 13,462,047 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1513,598,407 - 13,614,022 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01513,595,386 - 13,611,008 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1513,598,590 - 13,611,010 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,395,087 - 13,410,685 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01513,463,077 - 13,478,696 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01513,532,579 - 13,548,206 (+)NCBIUU_Cfam_GSD_1.0
Tal1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505862,223,080 - 62,238,124 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647428,047,808 - 28,056,065 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647428,049,326 - 28,061,495 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6164,283,366 - 164,295,290 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16164,282,242 - 164,297,636 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26151,830,187 - 151,846,169 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12085,681,247 - 85,697,887 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2085,688,155 - 85,694,829 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603331,381,681 - 31,398,704 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tal1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248595,586,977 - 5,601,460 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248595,586,489 - 5,601,225 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000042725   ⟹   ENSPPAP00000019944
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl148,042,594 - 48,048,622 (-)Ensembl
RefSeq Acc Id: XM_034964552   ⟹   XP_034820443
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21179,571,402 - 179,586,982 (+)NCBI
NHGRI_mPanPan11178,713,210 - 178,728,777 (+)NCBI
Mhudiblu_PPA_v0146,526,561 - 46,540,069 (-)NCBI
RefSeq Acc Id: XM_034964558   ⟹   XP_034820449
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21179,571,985 - 179,586,982 (+)NCBI
NHGRI_mPanPan11178,713,768 - 178,728,777 (+)NCBI
Mhudiblu_PPA_v0146,526,561 - 46,539,495 (-)NCBI
RefSeq Acc Id: XM_034964561   ⟹   XP_034820452
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21179,570,869 - 179,586,982 (+)NCBI
NHGRI_mPanPan11178,712,653 - 178,728,777 (+)NCBI
Mhudiblu_PPA_v0146,526,561 - 46,540,595 (-)NCBI
RefSeq Acc Id: XM_034964567   ⟹   XP_034820458
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21179,571,389 - 179,586,982 (+)NCBI
NHGRI_mPanPan11178,713,191 - 178,728,777 (+)NCBI
Mhudiblu_PPA_v0146,524,484 - 46,540,076 (-)NCBI
RefSeq Acc Id: XM_057298961   ⟹   XP_057154944
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21179,571,061 - 179,586,982 (+)NCBI
NHGRI_mPanPan11178,712,844 - 178,728,777 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034820443 (Get FASTA)   NCBI Sequence Viewer  
  XP_034820449 (Get FASTA)   NCBI Sequence Viewer  
  XP_034820452 (Get FASTA)   NCBI Sequence Viewer  
  XP_034820458 (Get FASTA)   NCBI Sequence Viewer  
  XP_057154944 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000019944.1
RefSeq Acc Id: XP_034820458   ⟸   XM_034964567
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AY24 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034820452   ⟸   XM_034964561
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034820443   ⟸   XM_034964552
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034820449   ⟸   XM_034964558
- Peptide Label: isoform X1
Ensembl Acc Id: ENSPPAP00000019944   ⟸   ENSPPAT00000042725
RefSeq Acc Id: XP_057154944   ⟸   XM_057298961
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AY24 (UniProtKB/TrEMBL)
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033189 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000042725.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  TAL-like UniProtKB/TrEMBL
NCBI Gene TAL1 ENTREZGENE
PANTHER PTHR13864 UniProtKB/TrEMBL
  T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A2R9AY24 ENTREZGENE, UniProtKB/TrEMBL