| 1346700 | SUFU | SUFU negative regulator of hedgehog signaling | The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene a re a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] | 10 | 102502819 | 102633535 | Human | 1853 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1556878 | Sufu | SUFU negative regulator of hedgehog signaling | Enables beta-catenin binding activity and protein sequestering activity. Involved in negative regulation of smoothened signaling pathway. Acts upstream of or within several processes, including circulatory system development; negative regulation of macromolecule metabolic process; and regionalizatio n. Located in cilium; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; sensory organ; and testis. Used to study nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 46385335 | 46477243 | Mouse | 247 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1559462 | Sufu | SUFU negative regulator of hedgehog signaling | ENCODES a protein that exhibits beta-catenin binding (ortholog); protein kinase binding (ortholog); protein sequestering activity (ortholog); INVOLVED IN positive regulation of cellular response to drug; spermatid development; aorta development (ortholog); PARTICIPATES IN Hedgehog signaling pathway; basal cell carcinoma pathway; ASSOCIATED WITH brain glioblastoma multiforme; medulloblastoma; pre-malignant neoplasm; FOUND IN cilium (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 255199108 | 255296983 | Rat | 156 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8834662 | Sufu | SUFU negative regulator of hedgehog signaling | ENCODES a protein that exhibits beta-catenin binding (ortholog); protein kinase binding (ortholog); protein sequestering activity (ortholog); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN Hedgeh og signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); basal cell carcinoma (ortholog); brain glioblastoma multiforme (ortholog); FOUND IN cilium (ortholog); cytoplasm (ortholog); GLI-SUFU complex (ortholog) | NW_004955485 | 7805244 | 7925414 | Chinchilla | 98 | symbol , name , description | gene, protein-coding, MODEL [RefSeq] |
| 11792506 | SUFU | SUFU negative regulator of hedgehog signaling | ENCODES a protein that exhibits beta-catenin binding (inferred); protein kinase binding (inferred); protein sequestering activity (inferred); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN Hedgeh og signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); basal cell carcinoma (ortholog); brain glioblastoma multiforme (ortholog); FOUND IN cytoplasm (ortholog) | 10 | 99107516 | 99231761 | Bonobo | 102 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12422745 | SUFU | SUFU negative regulator of hedgehog signaling | ENCODES a protein that exhibits beta-catenin binding (inferred); protein kinase binding (inferred); protein sequestering activity (inferred); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN Hedgeh og signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); basal cell carcinoma (ortholog); brain glioblastoma multiforme (ortholog); FOUND IN cilium (inferred); cytoplasm (inferred); cytosol (inferred) | 28 | 14992989 | 15115499 | Dog | 102 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12532727 | Sufu | SUFU negative regulator of hedgehog signaling | ENCODES a protein that exhibits beta-catenin binding (inferred); protein kinase binding (inferred); protein sequestering activity (inferred); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN Hedgeh og signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); basal cell carcinoma (ortholog); brain glioblastoma multiforme (ortholog); FOUND IN cytoplasm (ortholog) | NW_004936600 | 3270662 | 3381722 | Squirrel | 102 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18343130 | SUFU | SUFU negative regulator of hedgehog signaling | ENCODES a protein that exhibits beta-catenin binding (inferred); protein kinase binding (inferred); protein sequestering activity (inferred); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN Hedgeh og signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); basal cell carcinoma (ortholog); brain glioblastoma multiforme (ortholog); FOUND IN cytoplasm (ortholog) | | | | Green Monkey | 102 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18906481 | Sufu | SUFU negative regulator of hedgehog signaling | ENCODES a protein that exhibits beta-catenin binding (ortholog); protein kinase binding (ortholog); protein sequestering activity (ortholog); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN Hedgeh og signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); basal cell carcinoma (ortholog); brain glioblastoma multiforme (ortholog); FOUND IN cytoplasm (ortholog); GLI-SUFU complex (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 99 | symbol , name , description | gene, protein-coding, MODEL [RefSeq] |
| 14157424 | SUFU | SUFU negative regulator of hedgehog signaling | ENCODES a protein that exhibits beta-catenin binding (inferred); protein kinase binding (inferred); protein sequestering activity (inferred); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN Hedgeh og signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); basal cell carcinoma (ortholog); brain glioblastoma multiforme (ortholog); FOUND IN cilium (inferred); cytoplasm (inferred); cytosol (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 103 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 155232043 | sufu | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626010337 | Sufu | SUFU negative regulator of hedgehog signaling | ENCODES a protein that exhibits beta-catenin binding (ortholog); protein kinase binding (ortholog); protein sequestering activity (ortholog); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN Hedgeh og signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); basal cell carcinoma (ortholog); brain glioblastoma multiforme (ortholog); FOUND IN cilium (ortholog); cytoplasm (ortholog); GLI-SUFU complex (ortholog) | | | | Black Rat | 90 | symbol , name , description | gene, protein-coding, MODEL [RefSeq] |
| 155242556 | sufu.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232044 | sufu.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 18914930 | Gli3 | GLI family zinc finger 3 | ENCODES a protein that exhibits beta-catenin binding (ortholog); DNA-binding transcription factor activity (ortholog); histone acetyltransferase binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anterior semicircular canal development (ortholog); an terior/posterior pattern specification (ortholog); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH Abnormal Reflexes (ortholog); anodontia (ortholog); Anorectal Malformations (ortholog); FOUND IN cilium (ortholog); cytosol (ortholog); GLI-SUFU complex (ortholog) | | | | Naked Mole-Rat | 226 | description | gene, protein-coding, MODEL [RefSeq] |