| 708552 | Steap3 | STEAP3 metalloreductase | ENCODES a protein that exhibits cupric reductase (NADH) activity (ortholog); FAD binding (ortholog); ferric-chelate reductase (NADPH) activity (ortholog); INVOLVED IN positive regulation of apoptotic process; copper ion import (ortholog); exosomal secretion (ortholog); PARTICIPATES IN iron uptake pa thway; p53 signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); Hypochromic Microcytic Anemia with Iron Overload (ortholog); Hypochromic Microcytic Anemia with Iron Overload 2 (ortholog); FOUND IN cytoplasm (ortholog); endosome (ortholog); endosome membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 13 | 33904710 | 33950100 | Rat | 176 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1551194 | Steap3 | STEAP family member 3 | Enables cupric reductase (NADH) activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within exosomal secretion; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and transition metal ion transport. Located in endosome membrane and plasma membrane. Is expressed in several structures, including bone; genitourinary system; liver; nervous system; and white fat. Orthologous to human STEAP3 (STEAP3 metalloreductase). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 120154137 | 120198810 | Mouse | 228 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605372 | STEAP3 | STEAP3 metalloreductase | This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] | 2 | 119223834 | 119265652 | Human | 202 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8937194 | Steap3 | STEAP3 metalloreductase | ENCODES a protein that exhibits cupric reductase (NADH) activity (ortholog); FAD binding (ortholog); ferric-chelate reductase (NADPH) activity (ortholog); INVOLVED IN copper ion import (ortholog); exosomal secretion (ortholog); iron import into cell (ortholog); PARTICIPATES IN iron uptake pathway; A SSOCIATED WITH COVID-19 (ortholog); Hypochromic Microcytic Anemia with Iron Overload (ortholog); Hypochromic Microcytic Anemia with Iron Overload 2 (ortholog); FOUND IN cytoplasm (ortholog); endosome (ortholog); endosome membrane (ortholog) | NW_004955459 | 10441906 | 10485235 | Chinchilla | 29 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11746320 | STEAP3 | STEAP3 metalloreductase | ENCODES a protein that exhibits ferric-chelate reductase activity (ortholog); identical protein binding (ortholog); INVOLVED IN copper ion import (ortholog); exosomal secretion (ortholog); iron import into cell (ortholog); PARTICIPATES IN iron uptake pathway; ASSOCIATED WITH COVID-19 (ortholog); Hyp ochromic Microcytic Anemia with Iron Overload (ortholog); Hypochromic Microcytic Anemia with Iron Overload 2 (ortholog); FOUND IN cytoplasm (inferred); endosome (inferred); endosome membrane (inferred) | 2B | 6166296 | 6208338 | Bonobo | 33 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12238148 | STEAP3 | STEAP3 metalloreductase | ENCODES a protein that exhibits ferric-chelate reductase activity (ortholog); identical protein binding (ortholog); INVOLVED IN copper ion import (ortholog); exosomal secretion (ortholog); iron import into cell (ortholog); PARTICIPATES IN iron uptake pathway; ASSOCIATED WITH COVID-19 (ortholog); Hyp ochromic Microcytic Anemia with Iron Overload (ortholog); Hypochromic Microcytic Anemia with Iron Overload 2 (ortholog); FOUND IN endosome (ortholog); plasma membrane (ortholog) | 19 | 30745910 | 30795310 | Dog | 35 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12707263 | Steap3 | STEAP3 metalloreductase | ENCODES a protein that exhibits ferric-chelate reductase activity (ortholog); identical protein binding (ortholog); INVOLVED IN copper ion import (ortholog); exosomal secretion (ortholog); iron import into cell (ortholog); PARTICIPATES IN iron uptake pathway; ASSOCIATED WITH COVID-19 (ortholog); Hyp ochromic Microcytic Anemia with Iron Overload (ortholog); Hypochromic Microcytic Anemia with Iron Overload 2 (ortholog); FOUND IN cytoplasm (inferred); endosome (inferred); endosome membrane (inferred) | NW_004936469 | 51084250 | 51121738 | Squirrel | 33 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18928821 | Steap3 | STEAP3 metalloreductase | ENCODES a protein that exhibits FAD binding (ortholog); ferric-chelate reductase activity (ortholog); heme binding (ortholog); INVOLVED IN copper ion import (ortholog); exosomal secretion (ortholog); iron import into cell (ortholog); PARTICIPATES IN iron uptake pathway; ASSOCIATED WITH COVID-19 (ort holog); Hypochromic Microcytic Anemia with Iron Overload (ortholog); Hypochromic Microcytic Anemia with Iron Overload 2 (ortholog); FOUND IN cytoplasm (ortholog); multivesicular body (ortholog) | | | | Naked Mole-Rat | 32 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 598151169 | steap3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18442264 | STEAP3 | STEAP3 metalloreductase | ENCODES a protein that exhibits ferric-chelate reductase activity (ortholog); identical protein binding (ortholog); INVOLVED IN copper ion import (ortholog); exosomal secretion (ortholog); iron import into cell (ortholog); PARTICIPATES IN iron uptake pathway; ASSOCIATED WITH COVID-19 (ortholog); Hyp ochromic Microcytic Anemia with Iron Overload (ortholog); Hypochromic Microcytic Anemia with Iron Overload 2 (ortholog); FOUND IN cytoplasm (inferred); endosome (inferred); endosome membrane (inferred) | | | | Green Monkey | 33 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13935652 | STEAP3 | STEAP3 metalloreductase | ENCODES a protein that exhibits ferric-chelate reductase activity (ortholog); identical protein binding (ortholog); INVOLVED IN copper ion import (ortholog); exosomal secretion (ortholog); iron import into cell (ortholog); PARTICIPATES IN iron uptake pathway; ASSOCIATED WITH COVID-19 (ortholog); Hyp ochromic Microcytic Anemia with Iron Overload (ortholog); Hypochromic Microcytic Anemia with Iron Overload 2 (ortholog); FOUND IN endosome (ortholog); plasma membrane (ortholog) | | | | Pig | 35 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625928659 | Steap3 | STEAP3 metalloreductase | ENCODES a protein that exhibits cupric reductase (NADH) activity (ortholog); FAD binding (ortholog); ferric-chelate reductase (NADPH) activity (ortholog); INVOLVED IN copper ion import (ortholog); exosomal secretion (ortholog); iron import into cell (ortholog); PARTICIPATES IN iron uptake pathway; A SSOCIATED WITH COVID-19 (ortholog); Hypochromic Microcytic Anemia with Iron Overload (ortholog); Hypochromic Microcytic Anemia with Iron Overload 2 (ortholog); FOUND IN cytoplasm (ortholog); endosome (ortholog); endosome membrane (ortholog) | | | | Black Rat | 29 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 6481200 | STEAP3-AS1 | STEAP3 antisense RNA 1 | INTERACTS WITH okadaic acid; sodium arsenite | 2 | 119244422 | 119249071 | Human | 2 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |