STEAP3 (STEAP3 metalloreductase) - Rat Genome Database

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Gene: STEAP3 (STEAP3 metalloreductase) Homo sapiens
Analyze
Symbol: STEAP3
Name: STEAP3 metalloreductase
RGD ID: 1605372
HGNC Page HGNC
Description: Enables identical protein binding activity. Acts upstream of or within protein secretion. Located in multivesicular body.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1010001D01Rik; AHMIO2; dudlin 2; dudlin-2; dudulin 2; dudulin-2; hpHyde; hTSAP6; metalloreductase STEAP3; pHyde; six transmembrane prostate protein 3; six-transmembrane epithelial antigen of prostate 3; STEAP family member 3; STEAP family member 3, metalloreductase; STMP3; TSAP6; tumor suppressor pHyde; tumor suppressor-activated pathway protein 6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2119,223,831 - 119,265,652 (+)EnsemblGRCh38hg38GRCh38
GRCh382119,222,476 - 119,265,652 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372119,981,410 - 120,023,228 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362119,697,854 - 119,739,698 (+)NCBINCBI36hg18NCBI36
Celera2113,307,446 - 113,349,273 (+)NCBI
Cytogenetic Map2q14.2NCBI
HuRef2112,313,141 - 112,348,432 (+)NCBIHuRef
CHM1_12119,984,899 - 120,026,728 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (EXP)
all-trans-retinoic acid  (EXP)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP)
benzophenone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
diazinon  (EXP,ISO)
dieldrin  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
ethanol  (ISO)
formaldehyde  (EXP)
genistein  (EXP)
indometacin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
levofloxacin  (ISO)
methyl methanesulfonate  (EXP)
nefazodone  (ISO)
nickel sulfate  (EXP)
nimesulide  (ISO)
oxaliplatin  (ISO)
panobinostat  (EXP)
paracetamol  (EXP)
phenylmercury acetate  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
SB 431542  (EXP)
sunitinib  (EXP)
temozolomide  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10969787   PMID:11076863   PMID:11230166   PMID:11593405   PMID:12095985   PMID:12477932   PMID:12606722   PMID:12866033   PMID:14702039   PMID:15319436   PMID:15489336   PMID:15885357  
PMID:16381901   PMID:16609065   PMID:16651434   PMID:17695374   PMID:18495927   PMID:19016247   PMID:19236508   PMID:19302216   PMID:20379614   PMID:20587610   PMID:21871451   PMID:21873635  
PMID:21988832   PMID:22031863   PMID:22199357   PMID:22420032   PMID:22522456   PMID:22624035   PMID:22804687   PMID:23958962   PMID:25468996   PMID:26186194   PMID:26205815   PMID:26638075  
PMID:26675350   PMID:27173435   PMID:27825812   PMID:28303916   PMID:28514442   PMID:28692057   PMID:29180619   PMID:29395067   PMID:29568061   PMID:30194290   PMID:30442766   PMID:30639242  
PMID:31091453   PMID:31176711   PMID:31350307   PMID:31541095   PMID:31678930   PMID:31732153   PMID:33845483   PMID:33957083   PMID:33961781   PMID:34079125  


Genomics

Comparative Map Data
STEAP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2119,223,831 - 119,265,652 (+)EnsemblGRCh38hg38GRCh38
GRCh382119,222,476 - 119,265,652 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372119,981,410 - 120,023,228 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362119,697,854 - 119,739,698 (+)NCBINCBI36hg18NCBI36
Celera2113,307,446 - 113,349,273 (+)NCBI
Cytogenetic Map2q14.2NCBI
HuRef2112,313,141 - 112,348,432 (+)NCBIHuRef
CHM1_12119,984,899 - 120,026,728 (+)NCBICHM1_1
Steap3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,154,137 - 120,198,810 (-)NCBIGRCm39mm39
GRCm39 Ensembl1120,118,487 - 120,200,435 (-)Ensembl
GRCm381120,226,414 - 120,271,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,190,757 - 120,272,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv371122,122,993 - 122,167,659 (-)NCBIGRCm37mm9NCBIm37
MGSCv361122,054,752 - 122,092,804 (-)NCBImm8
Celera1122,886,890 - 122,931,707 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
Steap3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21331,351,954 - 31,397,344 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1331,351,954 - 31,396,519 (-)Ensembl
Rnor_6.01336,257,220 - 36,274,144 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,257,112 - 36,290,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,363,988 - 41,380,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,233,071 - 31,251,234 (-)NCBICelera
Cytogenetic Map13q11NCBI
Steap3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545910,441,752 - 10,485,269 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545910,441,906 - 10,485,235 (-)NCBIChiLan1.0ChiLan1.0
STEAP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B119,760,650 - 119,787,051 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B119,752,363 - 119,787,051 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B6,166,296 - 6,208,338 (+)NCBIMhudiblu_PPA_v0panPan3
STEAP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11930,745,910 - 30,795,310 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1930,747,921 - 30,795,338 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1931,010,053 - 31,054,670 (-)NCBI
ROS_Cfam_1.01932,130,144 - 32,174,780 (-)NCBI
UMICH_Zoey_3.11930,816,807 - 30,861,428 (-)NCBI
UNSW_CanFamBas_1.01930,982,936 - 31,027,552 (-)NCBI
UU_Cfam_GSD_1.01932,169,778 - 32,214,376 (-)NCBI
Steap3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,496,040 - 90,533,500 (+)NCBI
SpeTri2.0NW_00493646951,084,250 - 51,121,738 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STEAP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1524,736,594 - 24,787,871 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11524,736,556 - 24,785,376 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,419,225 - 28,467,997 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STEAP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11011,055,446 - 11,097,131 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1011,053,981 - 11,075,452 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606111,590,282 - 11,632,109 (+)NCBIVero_WHO_p1.0
Steap3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473225,913,034 - 25,958,537 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D2S2254  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372119,988,854 - 119,989,061UniSTSGRCh37
Build 362119,705,324 - 119,705,531RGDNCBI36
Celera2113,314,920 - 113,315,117RGD
Cytogenetic Map2q14.2UniSTS
HuRef2112,313,801 - 112,313,998UniSTS
Marshfield Genetic Map2128.41RGD
Marshfield Genetic Map2128.41UniSTS
Genethon Genetic Map2132.6UniSTS
Whitehead-YAC Contig Map2 UniSTS
RH99327  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372120,022,806 - 120,022,974UniSTSGRCh37
Build 362119,739,276 - 119,739,444RGDNCBI36
Celera2113,348,851 - 113,349,019RGD
Cytogenetic Map2q14.2UniSTS
HuRef2112,348,010 - 112,348,178UniSTS
GeneMap99-GB4 RH Map2435.27UniSTS
RH98234  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372120,014,235 - 120,014,368UniSTSGRCh37
Build 362119,730,705 - 119,730,838RGDNCBI36
Celera2113,340,280 - 113,340,413RGD
Cytogenetic Map2q14.2UniSTS
HuRef2112,339,442 - 112,339,575UniSTS
GeneMap99-GB4 RH Map2435.27UniSTS
SHGC-86162  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372120,018,304 - 120,018,606UniSTSGRCh37
Build 362119,734,774 - 119,735,076RGDNCBI36
Celera2113,344,348 - 113,344,650RGD
Cytogenetic Map2q14.2UniSTS
HuRef2112,343,508 - 112,343,810UniSTS
TNG Radiation Hybrid Map268656.0UniSTS
RH120128  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372120,018,477 - 120,018,822UniSTSGRCh37
Build 362119,734,947 - 119,735,292RGDNCBI36
Celera2113,344,521 - 113,344,866RGD
Cytogenetic Map2q14.2UniSTS
HuRef2112,343,681 - 112,344,026UniSTS
TNG Radiation Hybrid Map268652.0UniSTS
SHGC-10888  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372119,987,139 - 119,987,234UniSTSGRCh37
Build 362119,703,609 - 119,703,704RGDNCBI36
Celera2113,313,205 - 113,313,300RGD
Cytogenetic Map2q14.2UniSTS
HuRef2112,312,086 - 112,312,181UniSTS
Stanford-G3 RH Map25121.0UniSTS
SHGC-54575  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372120,023,040 - 120,023,219UniSTSGRCh37
Build 362119,739,510 - 119,739,689RGDNCBI36
Celera2113,349,085 - 113,349,264RGD
Cytogenetic Map2q14.2UniSTS
HuRef2112,348,244 - 112,348,423UniSTS
TNG Radiation Hybrid Map268660.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6603
Count of miRNA genes:845
Interacting mature miRNAs:1027
Transcripts:ENST00000354888, ENST00000393106, ENST00000393107, ENST00000393108, ENST00000393110, ENST00000409811, ENST00000425223, ENST00000450943
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 778 860 1074 603 413 445 2670 731 796 170 658 962 169 808 1545 3 2
Low 1661 2112 649 21 1445 20 1686 1460 2795 247 801 648 6 1 396 1243 3
Below cutoff 15 52 6 142 2 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_042823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001008410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_138637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_182915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006712614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006712615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011511403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC016673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC016736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF238864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF262322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF423424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK001691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY029585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY082673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY214461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM146930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX538047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000393106   ⟹   ENSP00000376818
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2119,223,831 - 119,265,652 (+)Ensembl
RefSeq Acc Id: ENST00000393107   ⟹   ENSP00000376819
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2119,223,853 - 119,263,698 (+)Ensembl
RefSeq Acc Id: ENST00000393110   ⟹   ENSP00000376822
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2119,223,834 - 119,265,652 (+)Ensembl
RefSeq Acc Id: ENST00000409811   ⟹   ENSP00000386510
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2119,223,853 - 119,263,698 (+)Ensembl
RefSeq Acc Id: NM_001008410   ⟹   NP_001008410
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382119,223,834 - 119,265,652 (+)NCBI
GRCh372119,981,384 - 120,023,228 (+)RGD
Build 362119,697,854 - 119,739,698 (+)NCBI Archive
Celera2113,307,446 - 113,349,273 (+)RGD
HuRef2112,313,141 - 112,348,432 (+)ENTREZGENE
CHM1_12119,984,899 - 120,026,728 (+)NCBI
Sequence:
RefSeq Acc Id: NM_018234   ⟹   NP_060704
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382119,223,834 - 119,265,652 (+)NCBI
GRCh372119,981,384 - 120,023,228 (+)RGD
Build 362119,697,854 - 119,739,698 (+)NCBI Archive
Celera2113,307,446 - 113,349,273 (+)RGD
HuRef2112,313,141 - 112,348,432 (+)ENTREZGENE
CHM1_12119,984,899 - 120,026,728 (+)NCBI
Sequence:
RefSeq Acc Id: NM_138637   ⟹   NP_619543
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382119,223,834 - 119,265,652 (+)NCBI
CHM1_12119,984,899 - 120,026,728 (+)NCBI
Sequence:
RefSeq Acc Id: NM_182915   ⟹   NP_878919
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382119,223,834 - 119,265,652 (+)NCBI
GRCh372119,981,384 - 120,023,228 (+)RGD
Build 362119,697,854 - 119,739,698 (+)NCBI Archive
Celera2113,307,446 - 113,349,273 (+)RGD
HuRef2112,313,141 - 112,348,432 (+)ENTREZGENE
CHM1_12119,984,899 - 120,026,728 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006712614   ⟹   XP_006712677
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382119,222,476 - 119,265,652 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006712615   ⟹   XP_006712678
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382119,244,424 - 119,265,652 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011511403   ⟹   XP_011509705
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382119,223,865 - 119,265,652 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_878919   ⟸   NM_182915
- Peptide Label: isoform a
- UniProtKB: Q658P3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_060704   ⟸   NM_018234
- Peptide Label: isoform b
- UniProtKB: Q658P3 (UniProtKB/Swiss-Prot),   A0A024RAD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001008410   ⟸   NM_001008410
- Peptide Label: isoform b
- UniProtKB: Q658P3 (UniProtKB/Swiss-Prot),   A0A024RAD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006712677   ⟸   XM_006712614
- Peptide Label: isoform X1
- UniProtKB: Q658P3 (UniProtKB/Swiss-Prot),   A0A024RAD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006712678   ⟸   XM_006712615
- Peptide Label: isoform X1
- UniProtKB: Q658P3 (UniProtKB/Swiss-Prot),   A0A024RAD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011509705   ⟸   XM_011511403
- Peptide Label: isoform X1
- UniProtKB: Q658P3 (UniProtKB/Swiss-Prot),   A0A024RAD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_619543   ⟸   NM_138637
- Peptide Label: isoform c
- UniProtKB: Q658P3 (UniProtKB/Swiss-Prot),   B8ZZX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000376822   ⟸   ENST00000393110
RefSeq Acc Id: ENSP00000376819   ⟸   ENST00000393107
RefSeq Acc Id: ENSP00000376818   ⟸   ENST00000393106
RefSeq Acc Id: ENSP00000386510   ⟸   ENST00000409811
Promoters
RGD ID:6861430
Promoter ID:EPDNEW_H3880
Type:initiation region
Name:STEAP3_1
Description:STEAP3 metalloreductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382119,223,836 - 119,223,896EPDNEW
RGD ID:6797186
Promoter ID:HG_KWN:34721
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000354888,   ENST00000393106,   ENST00000393107,   ENST00000393110,   UC010FLE.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362119,697,664 - 119,698,164 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_182915.3(STEAP3):c.330C>A (p.Cys110Ter) single nucleotide variant Hypochromic microcytic anemia with iron overload 2 [RCV000043521] Chr2:119245796 [GRCh38]
Chr2:120003372 [GRCh37]
Chr2:2q14.2
pathogenic
GRCh38/hg38 2q14.1-21.3(chr2:118086324-134964738)x1 copy number loss See cases [RCV000054058] Chr2:118086324..134964738 [GRCh38]
Chr2:118843900..135722308 [GRCh37]
Chr2:118560370..135438778 [NCBI36]
Chr2:2q14.1-21.3
pathogenic
NM_001008410.1(STEAP3):c.52G>A (p.Asp18Asn) single nucleotide variant Malignant melanoma [RCV000060310] Chr2:119245548 [GRCh38]
Chr2:120003124 [GRCh37]
Chr2:119719594 [NCBI36]
Chr2:2q14.2
not provided
NM_001008410.1(STEAP3):c.693C>T (p.Phe231=) single nucleotide variant Malignant melanoma [RCV000065039] Chr2:119247879 [GRCh38]
Chr2:120005455 [GRCh37]
Chr2:119721925 [NCBI36]
Chr2:2q14.2
not provided
GRCh38/hg38 2q14.1-14.3(chr2:115302067-129071130)x1 copy number loss See cases [RCV000141584] Chr2:115302067..129071130 [GRCh38]
Chr2:116059643..129828703 [GRCh37]
Chr2:115776113..129545173 [NCBI36]
Chr2:2q14.1-14.3
pathogenic
GRCh38/hg38 2q14.2-14.3(chr2:118687829-121621814)x1 copy number loss See cases [RCV000143725] Chr2:118687829..121621814 [GRCh38]
Chr2:119445405..122379390 [GRCh37]
Chr2:119161875..122095860 [NCBI36]
Chr2:2q14.2-14.3
pathogenic
GRCh37/hg19 2q12.3-14.3(chr2:109798247-125658380)x1 copy number loss See cases [RCV000240485] Chr2:109798247..125658380 [GRCh37]
Chr2:2q12.3-14.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
Single allele inversion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q13-14.3(chr2:114056441-123673800)x1 copy number loss See cases [RCV000511150] Chr2:114056441..123673800 [GRCh37]
Chr2:2q13-14.3
pathogenic
GRCh37/hg19 2q14.1-14.3(chr2:116754600-123897370)x1 copy number loss See cases [RCV000512514] Chr2:116754600..123897370 [GRCh37]
Chr2:2q14.1-14.3
pathogenic
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3
drug response
GRCh37/hg19 2q14.2(chr2:120003938-120280012)x3 copy number gain not provided [RCV000682050] Chr2:120003938..120280012 [GRCh37]
Chr2:2q14.2
likely benign
GRCh37/hg19 2q14.1-14.3(chr2:114707932-124328692)x1 copy number loss not provided [RCV000682164] Chr2:114707932..124328692 [GRCh37]
Chr2:2q14.1-14.3
pathogenic
GRCh37/hg19 2q14.1-14.3(chr2:117070953-126303416)x1 copy number loss not provided [RCV000753106] Chr2:117070953..126303416 [GRCh37]
Chr2:2q14.1-14.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_182915.3(STEAP3):c.1196G>A (p.Arg399Lys) single nucleotide variant not provided [RCV000896729] Chr2:119254829 [GRCh38]
Chr2:120012405 [GRCh37]
Chr2:2q14.2
likely benign
NM_182915.3(STEAP3):c.899G>A (p.Arg300His) single nucleotide variant not provided [RCV000904986] Chr2:119248055 [GRCh38]
Chr2:120005631 [GRCh37]
Chr2:2q14.2
benign
NM_182915.3(STEAP3):c.1338G>A (p.Leu446=) single nucleotide variant not provided [RCV000903710] Chr2:119263179 [GRCh38]
Chr2:120020755 [GRCh37]
Chr2:2q14.2
benign
NM_182915.3(STEAP3):c.43A>G (p.Met15Val) single nucleotide variant not provided [RCV000903653] Chr2:119245509 [GRCh38]
Chr2:120003085 [GRCh37]
Chr2:2q14.2
likely benign
NM_182915.3(STEAP3):c.645C>G (p.Pro215=) single nucleotide variant not provided [RCV000903654] Chr2:119247801 [GRCh38]
Chr2:120005377 [GRCh37]
Chr2:2q14.2
benign
NM_182915.3(STEAP3):c.677C>T (p.Thr226Ile) single nucleotide variant not provided [RCV000892509] Chr2:119247833 [GRCh38]
Chr2:120005409 [GRCh37]
Chr2:2q14.2
likely benign
NM_182915.3(STEAP3):c.881G>A (p.Arg294His) single nucleotide variant not provided [RCV000970428] Chr2:119248037 [GRCh38]
Chr2:120005613 [GRCh37]
Chr2:2q14.2
benign
NM_182915.3(STEAP3):c.1218C>T (p.Ser406=) single nucleotide variant not provided [RCV000970950] Chr2:119263059 [GRCh38]
Chr2:120020635 [GRCh37]
Chr2:2q14.2
benign
NM_182915.3(STEAP3):c.282G>A (p.Pro94=) single nucleotide variant not provided [RCV000946632] Chr2:119245748 [GRCh38]
Chr2:120003324 [GRCh37]
Chr2:2q14.2
benign
NM_182915.3(STEAP3):c.648G>A (p.Leu216=) single nucleotide variant not provided [RCV000926366] Chr2:119247804 [GRCh38]
Chr2:120005380 [GRCh37]
Chr2:2q14.2
likely benign
NM_182915.3(STEAP3):c.535G>A (p.Gly179Ser) single nucleotide variant not provided [RCV000881181] Chr2:119247691 [GRCh38]
Chr2:120005267 [GRCh37]
Chr2:2q14.2
benign
NM_182915.3(STEAP3):c.1269C>T (p.Tyr423=) single nucleotide variant not provided [RCV000976606] Chr2:119263110 [GRCh38]
Chr2:120020686 [GRCh37]
Chr2:2q14.2
benign
NM_182915.3(STEAP3):c.1019G>A (p.Arg340His) single nucleotide variant not provided [RCV000880063] Chr2:119248175 [GRCh38]
Chr2:120005751 [GRCh37]
Chr2:2q14.2
likely benign
NM_182915.3(STEAP3):c.1023C>T (p.Tyr341=) single nucleotide variant not provided [RCV000920760] Chr2:119248179 [GRCh38]
Chr2:120005755 [GRCh37]
Chr2:2q14.2
likely benign
GRCh37/hg19 2q14.2-14.3(chr2:118903294-123099547)x1 copy number loss not provided [RCV001005310] Chr2:118903294..123099547 [GRCh37]
Chr2:2q14.2-14.3
pathogenic
GRCh37/hg19 2q14.2(chr2:119905466-120016024)x1 copy number loss not provided [RCV001005312] Chr2:119905466..120016024 [GRCh37]
Chr2:2q14.2
likely benign|uncertain significance
GRCh37/hg19 2q14.2(chr2:119859810-120157980)x3 copy number gain not provided [RCV001005311] Chr2:119859810..120157980 [GRCh37]
Chr2:2q14.2
likely benign
NM_182915.3(STEAP3):c.1451C>T (p.Thr484Met) single nucleotide variant not provided [RCV000902567] Chr2:119263292 [GRCh38]
Chr2:120020868 [GRCh37]
Chr2:2q14.2
likely benign
NM_182915.3(STEAP3):c.1011C>T (p.Arg337=) single nucleotide variant not provided [RCV000884390] Chr2:119248167 [GRCh38]
Chr2:120005743 [GRCh37]
Chr2:2q14.2
benign
GRCh37/hg19 2q14.1-14.2(chr2:115416190-122399064)x1 copy number loss not provided [RCV001005308] Chr2:115416190..122399064 [GRCh37]
Chr2:2q14.1-14.2
pathogenic
GRCh37/hg19 2q14.2-14.3(chr2:118872395-128069813)x1 copy number loss not provided [RCV001005309] Chr2:118872395..128069813 [GRCh37]
Chr2:2q14.2-14.3
pathogenic
NM_182915.3(STEAP3):c.1215+2654A>T single nucleotide variant Hypochromic microcytic anemia with iron overload 2 [RCV001335521] Chr2:119257502 [GRCh38]
Chr2:120015078 [GRCh37]
Chr2:2q14.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:24592 AgrOrtholog
COSMIC STEAP3 COSMIC
Ensembl Genes ENSG00000115107 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000376818 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000376819 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000376822 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000386510 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000393106 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000393107 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000393110 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409811 ENTREZGENE, UniProtKB/TrEMBL
GTEx ENSG00000115107 GTEx
HGNC ID HGNC:24592 ENTREZGENE
Human Proteome Map STEAP3 Human Proteome Map
InterPro Fe3_Rdtase_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P5C_Rdtase_cat_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:55240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 55240 ENTREZGENE
OMIM 609671 OMIM
  615234 OMIM
Pfam F420_oxidored UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferric_reduct UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142670863 PharmGKB
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RAD7 ENTREZGENE
  A1P3F0_HUMAN UniProtKB/TrEMBL
  B8ZZX6 ENTREZGENE, UniProtKB/TrEMBL
  Q658P3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8K6E3 UniProtKB/Swiss-Prot
  Q4VBR2 UniProtKB/Swiss-Prot
  Q4ZG36 UniProtKB/Swiss-Prot
  Q53SQ8 UniProtKB/Swiss-Prot
  Q7Z389 UniProtKB/Swiss-Prot
  Q86SF6 UniProtKB/Swiss-Prot
  Q8NEW6 UniProtKB/Swiss-Prot
  Q8TDP3 UniProtKB/Swiss-Prot
  Q8TF03 UniProtKB/Swiss-Prot
  Q9NVB5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 STEAP3  STEAP3 metalloreductase    STEAP family member 3, metalloreductase  Symbol and/or name change 5135510 APPROVED
2011-10-04 STEAP3  STEAP family member 3, metalloreductase  STEAP3  STEAP family member 3  Symbol and/or name change 5135510 APPROVED