Steap3 (STEAP3 metalloreductase) - Rat Genome Database

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Gene: Steap3 (STEAP3 metalloreductase) Ictidomys tridecemlineatus
Analyze
Symbol: Steap3
Name: STEAP3 metalloreductase
RGD ID: 12707263
Description: ENCODES a protein that exhibits ferric-chelate reductase activity (ortholog); identical protein binding (ortholog); INVOLVED IN copper ion import (ortholog); establishment of localization in cell (ortholog); exosomal secretion (ortholog); PARTICIPATES IN iron uptake pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); Hypochromic Microcytic Anemia with Iron Overload (ortholog); FOUND IN cytoplasm (inferred); endosome (inferred); endosome membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: metalloreductase STEAP3; STEAP3 metalloreductase, transcript variant X1; STEAP3 metalloreductase, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,496,040 - 90,533,500 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646951,054,517 - 51,126,664 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646951,084,250 - 51,121,738 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Steap3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,496,040 - 90,533,500 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646951,054,517 - 51,126,664 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646951,084,250 - 51,121,738 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STEAP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382119,223,834 - 119,265,652 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2119,223,831 - 119,265,652 (+)EnsemblGRCh38hg38GRCh38
GRCh372119,981,410 - 120,023,228 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362119,697,854 - 119,739,698 (+)NCBINCBI36Build 36hg18NCBI36
Celera2113,307,446 - 113,349,273 (+)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2112,313,141 - 112,348,432 (+)NCBIHuRef
CHM1_12119,984,899 - 120,026,728 (+)NCBICHM1_1
T2T-CHM13v2.02119,657,360 - 119,699,155 (+)NCBIT2T-CHM13v2.0
Steap3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,154,137 - 120,198,810 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,118,487 - 120,200,435 (-)EnsemblGRCm39 Ensembl
GRCm381120,226,414 - 120,271,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,190,757 - 120,272,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv371122,122,993 - 122,167,659 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,054,752 - 122,092,804 (-)NCBIMGSCv36mm8
Celera1122,886,890 - 122,931,707 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.66NCBI
Steap3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,904,710 - 33,950,100 (-)NCBIGRCr8
mRatBN7.21331,351,954 - 31,397,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,351,954 - 31,396,519 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1333,919,075 - 33,958,529 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,206,922 - 35,246,367 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,481,358 - 32,520,829 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01336,257,220 - 36,274,144 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,257,112 - 36,290,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,363,988 - 41,380,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,233,071 - 31,251,234 (-)NCBICelera
Cytogenetic Map13q11NCBI
Steap3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545910,441,752 - 10,485,269 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545910,441,906 - 10,485,235 (-)NCBIChiLan1.0ChiLan1.0
STEAP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21321,232,416 - 21,274,503 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B21,269,221 - 21,289,476 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B6,166,296 - 6,208,338 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B119,760,650 - 119,787,051 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B119,752,363 - 119,787,051 (+)Ensemblpanpan1.1panPan2
STEAP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11930,745,910 - 30,795,310 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1930,747,921 - 30,795,338 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1931,010,053 - 31,054,670 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01932,130,144 - 32,174,780 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1932,130,148 - 32,179,975 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11930,816,807 - 30,861,428 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01930,982,936 - 31,027,552 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01932,169,778 - 32,214,376 (-)NCBIUU_Cfam_GSD_1.0
STEAP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1524,736,594 - 24,787,865 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11524,736,556 - 24,785,376 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,419,225 - 28,467,997 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STEAP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11011,055,446 - 11,097,131 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1011,053,981 - 11,075,452 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606111,590,282 - 11,632,109 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Steap3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473225,913,736 - 25,958,582 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473225,913,034 - 25,958,537 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000008258   ⟹   ENSSTOP00000007398
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493646951,086,867 - 51,126,664 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000037832   ⟹   ENSSTOP00000029558
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493646951,084,402 - 51,121,738 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000042996   ⟹   ENSSTOP00000027424
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493646951,054,517 - 51,115,459 (-)Ensembl
RefSeq Acc Id: XM_013355745   ⟹   XP_013211199
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530390,496,040 - 90,533,500 (+)NCBI
SpeTri2.0NW_00493646951,084,250 - 51,121,738 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040294107   ⟹   XP_040150041
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530390,502,179 - 90,533,500 (+)NCBI
Protein Sequences
Protein RefSeqs XP_013211199 (Get FASTA)   NCBI Sequence Viewer  
  XP_040150041 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000007398.3
  ENSSTOP00000027424.1
  ENSSTOP00000029558.1
GenBank Protein KAG3274241 (Get FASTA)   NCBI Sequence Viewer  
  KAG3274242 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_013211199   ⟸   XM_013355745
- Peptide Label: isoform X2
- UniProtKB: A0A287D7P8 (UniProtKB/TrEMBL),   I3MBB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040150041   ⟸   XM_040294107
- Peptide Label: isoform X1
- UniProtKB: A0A287D1L0 (UniProtKB/TrEMBL),   I3MBB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000007398   ⟸   ENSSTOT00000008258
RefSeq Acc Id: ENSSTOP00000027424   ⟸   ENSSTOT00000042996
RefSeq Acc Id: ENSSTOP00000029558   ⟸   ENSSTOT00000037832
Protein Domains
Ferric oxidoreductase   Pyrroline-5-carboxylate reductase catalytic N-


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008264 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008258.3 UniProtKB/TrEMBL
  ENSSTOT00000037832.1 UniProtKB/TrEMBL
  ENSSTOT00000042996.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Fe3_Rdtase_TM_dom UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  P5C_Rdtase_cat_N UniProtKB/TrEMBL
NCBI Gene Steap3 ENTREZGENE
PANTHER DUDULIN-RELATED UniProtKB/TrEMBL
  METALLOREDUCTASE STEAP3 UniProtKB/TrEMBL
Pfam F420_oxidored UniProtKB/TrEMBL
  Ferric_reduct UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt A0A287D1L0 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D7P8 ENTREZGENE, UniProtKB/TrEMBL
  I3MBB0 ENTREZGENE, UniProtKB/TrEMBL