| 3773 | Stat5a | signal transducer and activator of transcription 5A | ENCODES a protein that exhibits DNA-binding transcription factor activity; double-stranded DNA binding; sequence-specific DNA binding; INVOLVED IN cell surface receptor signaling pathway via JAK-STAT; cellular response to cytokine stimulus; lactation; PARTICIPATES IN Jak-Stat signaling pathway; eryt hropoietin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; ASSOCIATED WITH Acute-Phase Reaction; Experimental Liver Cirrhosis; Experimental Mammary Neoplasms; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 6-propyl-2-thiouracil | 10 | 86285859 | 86310187 | Rat | 423 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 11351 | Stat5a | signal transducer and activator of transcription 5A | Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and phosphate ion binding activity. Involved in growth hormone receptor signaling pathway via JAK-STAT and regulation of growth. Acts upst ream of with a positive effect on taurine metabolic process. Acts upstream of or within several processes, including positive regulation of leukocyte proliferation; regulation of hemopoiesis; and reproductive structure development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human STAT5A (signal transducer and activator of transcription 5A). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 100750177 | 100775995 | Mouse | 568 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 737523 | STAT5A | signal transducer and activator of transcription 5A | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] | 17 | 42287439 | 42311943 | Human | 406 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8700775 | Stat5a | signal transducer and activator of transcription 5A | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cellular response to cytokin e stimulus (ortholog); cellular response to granulocyte macrophage colony-stimulating factor stimulus (ortholog); PARTICIPATES IN erythropoietin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH Acute-Phase Reaction (ortholog); adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955451 | 16305363 | 16319219 | Chinchilla | 158 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12288151 | STAT5A | signal transducer and activator of transcription 5A | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cellular response to cytokine stimulus (ortholog); cell ular response to granulocyte macrophage colony-stimulating factor stimulus (ortholog); PARTICIPATES IN erythropoietin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH Acute-Phase Reaction (ortholog); adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 9 | 20616041 | 20638523 | Dog | 183 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18385617 | STAT5A | signal transducer and activator of transcription 5A | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cellular response to cytokine stimulus (ortholog); cell ular response to granulocyte macrophage colony-stimulating factor stimulus (ortholog); PARTICIPATES IN erythropoietin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH Acute-Phase Reaction (ortholog); adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 172 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14015331 | STAT5A | signal transducer and activator of transcription 5A | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cellular response to cytokine stimulus (ortholog); cellular response to g ranulocyte macrophage colony-stimulating factor stimulus (ortholog); PARTICIPATES IN erythropoietin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH Acute-Phase Reaction (ortholog); adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Pig | 211 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 11689961 | LOC100988550 | signal transducer and activator of transcription 5A | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cellular response to cytokine stimulus (ortholog); cell ular response to granulocyte macrophage colony-stimulating factor stimulus (ortholog); PARTICIPATES IN erythropoietin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH Acute-Phase Reaction (ortholog); adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 17 | 15005025 | 15029110 | Bonobo | 172 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18909998 | LOC101723770 | signal transducer and activator of transcription 5A | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); regulation of DNA-templated transcription (inferred); signal transduction (inferred); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 7 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12735903 | LOC101954799 | signal transducer and activator of transcription 5A | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (inferred); DNA-templated transcription (inferred); eosinophil differentiation (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | NW_004936490 | 17095047 | 17115945 | Squirrel | 43 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |