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23 records found for search term Srd5a2
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RGD IDSymbolNameDescriptionChrStartStopSpeciesAnnotationsMatchType
621480Srd5a2steroid 5 alpha-reductase 2ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity; amide binding; 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity (ortholog); INVOLVED IN androgen biosynthetic process; androgen metabolic process; bone development; PARTICIPATES IN testosterone biosynthetic pathway62717808927217588Rat212symbol , PhenoGengene, protein-coding, VALIDATED [RefSeq]
737503SRD5A2steroid 5 alpha-reductase 2This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically 23152248031663009Human318symbol , COSMIC , Human Proteome Mapgene, protein-coding, REVIEWED [RefSeq]
737504Srd5a2steroid 5 alpha-reductase 2Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Involved in androgen biosynthetic process. Acts upstream of or within male genitalia development and steroid biosynthetic process. Predicted to be located in cell body fiber and neuronal cell body. Predicted to be active in endoplasmic reticulu177432188674354855Mouse247symbol , PhenoGen , descriptiongene, protein-coding, VALIDATED [RefSeq]
8830058Srd5a2steroid 5 alpha-reductase 2ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity (ortholog); 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen metabolic process (ortholog); bone development (orthoNW_0049554411214995733Chinchilla54symbolgene, protein-coding, MODEL [RefSeq]
11750152SRD5A2steroid 5 alpha-reductase 2ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen metabolic process (ortholog); bone development (ortholog); PARTICIPATES IN testosterone biosynthetic pathway; ASSOCIATED2A3154264631597394Bonobo71symbolgene, protein-coding, MODEL [RefSeq]
12093350SRD5A2steroid 5 alpha-reductase 2ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen metabolic process (ortholog); bone development (ortholog); PARTICIPATES IN testosterone biosynthetic pathway; ASSOCIATED172501711325056156Dog71symbolgene, protein-coding, VALIDATED [RefSeq]
12450140Srd5a2steroid 5 alpha-reductase 2ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen metabolic process (ortholog); bone development (ortholog); PARTICIPATES IN testosterone biosynthetic pathway; ASSOCIATEDNW_00493649316639991708530Squirrel71symbolgene, protein-coding, MODEL [RefSeq]
18603660SRD5A2steroid 5 alpha-reductase 2ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen metabolic process (ortholog); bone development (ortholog); PARTICIPATES IN testosterone biosynthetic pathway; ASSOCIATEDGreen Monkey71symbolgene, protein-coding, MODEL [RefSeq]
626092692Srd5a2steroid 5 alpha-reductase 2ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity (ortholog); 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen metabolic process (ortholog); bone development (orthoBlack Rat54symbolgene, protein-coding, MODEL [RefSeq]
18921069Srd5a2steroid 5 alpha-reductase 2ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen metabolic process (ortholog); bone development (ortholog); PARTICIPATES IN testosterone biosynthetic pathway; ASSOCIATEDNaked Mole-Rat70symbolgene, protein-coding, MODEL [RefSeq]
14205943SRD5A2steroid 5 alpha-reductase 2ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); testosterone dehydrogenase (NADP+) activity (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen metabolic process (ortholog); bone development (ortholog); PARTIPig69symbolgene, protein-coding, PROVISIONAL [RefSeq]
155236632srd5a2Tropical Clawed Frogsymbolgene, null
155236633srd5a2.LAfrican Clawed Frogsymbolgene, null
155251631srd5a2.SAfrican Clawed Frogsymbolgene, null
39128266SRD5A2P1SRD5A2 pseudogene 1X155310247155310490Humansymbol , COSMIC , name , Human Proteome Mapgene, pseudo, INFERRED [RefSeq]
16554737SRD5A2P1SRD5A2 pseudogene 1Humansymbol , old_gene_name , COSMIC , name , Human Proteome Mapgene, processed_pseudogene
1332323Srd5a3steroid 5 alpha-reductase 3Predicted to enable 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity; polyprenal reductase activity; and polyprenol reductase activity. Involved in dolichol metabolic process; dolichol-linked oligosaccharide biosynthetic process; and polyprenol catabolic process. Predicted to be located in end57628529676303350Mouse148old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1606233SRD5A3steroid 5 alpha-reductase 3The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein i45534624255373100Human238old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
1304608Tecrltrans-2,3-enoyl-CoA reductase-likeENCODES a protein that exhibits oxidoreductase activity (inferred); oxidoreductase activity, acting on the CH-CH group of donors (inferred); INVOLVED IN lipid metabolic process (inferred); ASSOCIATED WITH catecholaminergic polymorphic ventricular tachycardia (ortholog); catecholaminergic polymorphic142508693025159957Rat46old_gene_symbolgene, protein-coding, PROVISIONAL [RefSeq]
1312145Tecrltrans-2,3-enoyl-CoA reductase-likePredicted to enable oxidoreductase activity. Predicted to be involved in very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 3. Orthologous to human TECRL58342596983503042Mouse55old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1604717TECRLtrans-2,3-enoyl-CoA reductase likeThe protein encoded by this gene contains a ubiquitin-like domain in the N-terminal region, three transmembrane segments and a C-terminal 3-oxo-5-alpha steroid 4-dehydrogenase domain. The protein belongs to the steroid 5-alpha reductase family. Mutations in this gene result in ventricular tachycardi46427629864409460Human76old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
736446SRD5A1steroid 5 alpha-reductase 1Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]566334406674386Human351descriptiongene, protein-coding, VALIDATED [RefSeq]
1308828Srd5a3steroid 5 alpha-reductase 3ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity (ortholog); oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor (ortholog); polyprenal reductase activity (ortholog); INVOLVED IN dolichol-linked oligosaccharide biosynthetic proc143240060332414987Rat143old_gene_namegene, protein-coding, VALIDATED [RefSeq]