| 3717 | Slc8a1 | solute carrier family 8 member A1 | ENCODES a protein that exhibits calcium:sodium antiporter activity; ankyrin binding (ortholog); calcium ion binding (ortholog); INVOLVED IN calcium ion export; calcium ion import; calcium ion transmembrane transport; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agoni st and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH brain ischemia; Cardiomegaly; congestive heart failure; FOUND IN axon; cell projection; dendrite; INTERACTS WITH (R)-noradrenaline; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 17alpha-ethynylestradiol | 6 | 18975498 | 19299704 | Rat | 439 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731021 | SLC8A1 | solute carrier family 8 member A1 | In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004] | 2 | 40097270 | 40512435 | Human | 403 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 731022 | Slc8a1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | Enables ankyrin binding activity; calcium:sodium antiporter activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to caffeine; metal ion transport; and vascular associated smooth muscle contraction. Acts upstream of or within several pro cesses, including embryonic organ development; metal ion transport; and regulation of macromolecule metabolic process. Located in several cellular components, including T-tubule; basolateral plasma membrane; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and nose. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 81680534 | 82045816 | Mouse | 507 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9036209 | Slc8a1 | solute carrier family 8 member A1 | ENCODES a protein that exhibits ankyrin binding (ortholog); calcium ion binding (ortholog); calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); INVOLVED IN calcium ion export (ortholog); calcium ion homeostasis (ortholo g); calcium ion import (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Cardiomegaly (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); basolateral plasma membrane (ortholog) | NW_004955441 | 7653107 | 8037784 | Chinchilla | 182 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11702843 | SLC8A1 | solute carrier family 8 member A1 | ENCODES a protein that exhibits calcium ion binding (ortholog); calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); calcium:sodium antiporter activity (ortholog); INVOLVED IN calcium ion export (ortholog); calcium ion h omeostasis (ortholog); calcium ion transmembrane transport (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Cardiomegaly (ortholog); FOUND IN axon terminus (ortholog); basolateral plasma membrane (ortholog); cell projection (ortholog) | 2A | 40169339 | 40586546 | Bonobo | 182 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12334269 | SLC8A1 | solute carrier family 8 member A1 | ENCODES a protein that exhibits calcium ion binding; calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration; calcium:sodium antiporter activity; INVOLVED IN calcium ion transmembrane transport; sodium ion transmembrane transport; calc ium ion export (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Cardiomegaly (ortholog); FOUND IN plasma membrane; axon (ortholog); axon terminus (ortholog); INTERACTS WITH allopurinol; amiodarone; calcium atom | 17 | 32004207 | 32381399 | Dog | 195 | symbol | gene, protein-coding, INFERRED [RefSeq] |
| 12693992 | Slc8a1 | solute carrier family 8 member A1 | ENCODES a protein that exhibits calcium ion binding (ortholog); calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); calcium:sodium antiporter activity (ortholog); INVOLVED IN calcium ion export (ortholog); calcium ion t ransmembrane transport (ortholog); calcium ion transport (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Cardiomegaly (ortholog); FOUND IN axon terminus (ortholog); basolateral plasma membrane (ortholog); cell projection (ortholog) | NW_004936508 | 10894918 | 11256084 | Squirrel | 182 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910903 | Slc8a1 | solute carrier family 8 member A1 | ENCODES a protein that exhibits ankyrin binding (ortholog); calcium ion binding (ortholog); calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); INVOLVED IN calcium ion export (ortholog); calcium ion import (ortholog); c alcium ion transmembrane transport (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Cardiomegaly (ortholog); FOUND IN axon terminus (ortholog); basolateral plasma membrane (ortholog); cell periphery (ortholog) | | | | Naked Mole-Rat | 188 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625934285 | Slc8a1 | solute carrier family 8 member A1 | ENCODES a protein that exhibits ankyrin binding (ortholog); calcium ion binding (ortholog); calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); INVOLVED IN calcium ion export (ortholog); calcium ion homeostasis (ortholo g); calcium ion import (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Cardiomegaly (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); basolateral plasma membrane (ortholog) | | | | Black Rat | 182 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13921021 | SLC8A1 | solute carrier family 8 member A1 | ENCODES a protein that exhibits calcium ion binding (ortholog); calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); calcium:sodium antiporter activity (ortholog); INVOLVED IN calcium ion export (ortholog); calcium ion h omeostasis (ortholog); calcium ion transmembrane transport (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Cardiomegaly (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); basolateral plasma membrane (ortholog); INTERACTS WITH cadmium atom | | | | Pig | 186 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18537511 | SLC8A1 | solute carrier family 8 member A1 | ENCODES a protein that exhibits ankyrin binding (ortholog); calcium ion binding (ortholog); calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); INVOLVED IN calcium ion export (ortholog); calcium ion homeostasis (ortholo g); calcium ion import (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Cardiomegaly (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); basolateral plasma membrane (ortholog) | | | | Green Monkey | 182 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251354 | slc8a1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 20866872 | SLC8A1 | solute carrier family 8 member A1 | ENCODES a protein that exhibits ankyrin binding (inferred); antiporter activity (inferred); calcium:sodium antiporter activity (inferred); INVOLVED IN calcium ion import (inferred); calcium ion import across plasma membrane (inferred); calcium ion transmembrane transport (inferred); FOUND IN axon (i nferred); cell periphery (inferred); membrane (inferred) | | | | Green Monkey | 37 | symbol | gene, protein-coding |
| 405857329 | slc8a1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468864 | slc8a1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858509 | slc8a1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864410 | slc8a1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859640 | slc8a1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259234 | slc8a1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6767272 | SLC8A1-AS1 | SLC8A1 antisense RNA 1 | INTERACTS WITH antirheumatic drug; diuron | 2 | 39917634 | 40255209 | Human | 2 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 38670602 | LOC101929667 | uncharacterized LOC101929667 | | 2 | 40511922 | 40558453 | Human | | old_gene_name | gene, ncrna, MODEL [RefSeq] |
