SLC8A1 (solute carrier family 8 member A1) - Rat Genome Database

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Gene: SLC8A1 (solute carrier family 8 member A1) Chlorocebus sabaeus
Analyze
Symbol: SLC8A1
Name: solute carrier family 8 member A1
RGD ID: 18537511
Description: ENCODES a protein that exhibits ankyrin binding (ortholog); calcium ion binding (ortholog); calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); INVOLVED IN calcium ion export (ortholog); calcium ion homeostasis (ortholog); calcium ion import (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Cardiomegaly (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium/calcium exchanger 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11466,813,523 - 67,210,261 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604544,751,652 - 45,239,417 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion export  (ISO)
calcium ion homeostasis  (ISO)
calcium ion import  (ISO)
calcium ion transmembrane transport  (ISO)
calcium ion transport  (ISO)
calcium ion transport into cytosol  (ISO)
cardiac muscle cell development  (ISO)
cardiac muscle contraction  (ISO)
cell communication by electrical coupling involved in cardiac conduction  (ISO)
cellular response to caffeine  (ISO)
cellular response to cAMP  (ISO)
cellular response to hypoxia  (ISO)
cellular response to reactive oxygen species  (ISO)
embryonic heart tube development  (ISO)
embryonic placenta development  (ISO)
heart morphogenesis  (ISO)
intracellular calcium ion homeostasis  (ISO)
intracellular sodium ion homeostasis  (ISO)
muscle cell development  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of the force of heart contraction  (ISO)
post-embryonic development  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (ISO)
regulation of gene expression  (ISO)
regulation of heart rate  (ISO)
regulation of sodium ion transport  (ISO)
regulation of the force of heart contraction  (ISO)
relaxation of smooth muscle  (ISO)
response to ATP  (ISO)
response to glucose  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to muscle stretch  (ISO)
response to nutrient  (ISO)
response to xenobiotic stimulus  (ISO)
sodium ion export across plasma membrane  (ISO)
sodium ion import across plasma membrane  (ISO)
sodium ion transmembrane transport  (ISO)
sodium ion transport  (ISO)
telencephalon development  (ISO)
vascular associated smooth muscle contraction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC8A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11466,813,523 - 67,210,261 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604544,751,652 - 45,239,417 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SLC8A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38240,097,270 - 40,512,435 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl240,097,270 - 40,611,053 (-)EnsemblGRCh38hg38GRCh38
GRCh37240,324,410 - 40,739,575 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36240,192,790 - 40,510,948 (-)NCBINCBI36Build 36hg18NCBI36
Build 34240,253,795 - 40,569,095NCBI
Celera240,180,223 - 40,580,364 (-)NCBICelera
Cytogenetic Map2p22.1NCBI
HuRef240,078,719 - 40,478,536 (-)NCBIHuRef
CHM1_1240,269,776 - 40,669,965 (-)NCBICHM1_1
T2T-CHM13v2.0240,106,262 - 40,521,419 (-)NCBIT2T-CHM13v2.0
Slc8a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391781,680,534 - 82,045,816 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1781,680,534 - 82,045,806 (-)EnsemblGRCm39 Ensembl
GRCm381781,373,105 - 81,738,387 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1781,373,105 - 81,738,377 (-)EnsemblGRCm38mm10GRCm38
MGSCv371781,772,445 - 82,137,717 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361781,293,929 - 81,646,695 (-)NCBIMGSCv36mm8
Celera1785,706,575 - 86,071,957 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1751.29NCBI
Slc8a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8618,975,498 - 19,299,704 (+)NCBIGRCr8
mRatBN7.2613,194,609 - 13,547,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl613,194,662 - 13,535,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx613,583,983 - 13,850,400 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0613,893,299 - 14,159,696 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0613,388,155 - 13,652,568 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.064,244,076 - 4,564,262 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl64,258,991 - 4,520,604 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.064,208,126 - 4,495,690 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.464,421,046 - 4,691,716 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.164,421,045 - 4,691,719 (-)NCBI
Celera612,962,979 - 13,227,191 (+)NCBICelera
Cytogenetic Map6q12NCBI
Slc8a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554417,656,031 - 7,957,640 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554417,653,107 - 8,037,784 (-)NCBIChiLan1.0ChiLan1.0
SLC8A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21285,919,909 - 86,321,105 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A85,923,870 - 86,341,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A40,169,339 - 40,586,546 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A40,936,799 - 41,444,963 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A40,939,900 - 41,363,038 (-)Ensemblpanpan1.1panPan2
SLC8A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11732,004,207 - 32,381,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1732,005,245 - 32,307,700 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1731,772,774 - 32,072,461 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01732,669,189 - 33,057,808 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1732,668,180 - 32,983,961 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11731,887,301 - 32,186,904 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01731,956,496 - 32,256,674 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01732,171,264 - 32,471,231 (-)NCBIUU_Cfam_GSD_1.0
Slc8a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629239,466,272 - 39,841,883 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650810,968,656 - 11,253,070 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650810,894,918 - 11,256,084 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC8A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl399,897,162 - 100,244,759 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1399,823,503 - 100,257,306 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23106,268,345 - 106,367,008 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Slc8a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473821,651,489 - 21,939,927 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473821,648,277 - 22,026,385 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007970836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007970858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038006243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_007970858   ⟹   XP_007969049
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11466,813,525 - 67,210,261 (+)NCBI
Vero_WHO_p1.0NW_02366604544,751,652 - 45,138,363 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038006229   ⟹   XP_037862157
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,239,406 (-)NCBI
RefSeq Acc Id: XM_038006230   ⟹   XP_037862158
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,239,404 (-)NCBI
RefSeq Acc Id: XM_038006231   ⟹   XP_037862159
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,239,402 (-)NCBI
RefSeq Acc Id: XM_038006232   ⟹   XP_037862160
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,239,397 (-)NCBI
RefSeq Acc Id: XM_038006233   ⟹   XP_037862161
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,081,717 (-)NCBI
RefSeq Acc Id: XM_038006234   ⟹   XP_037862162
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,185,663 (-)NCBI
RefSeq Acc Id: XM_038006235   ⟹   XP_037862163
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,239,398 (-)NCBI
RefSeq Acc Id: XM_038006236   ⟹   XP_037862164
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,138,377 (-)NCBI
RefSeq Acc Id: XM_038006237   ⟹   XP_037862165
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,081,170 (-)NCBI
RefSeq Acc Id: XM_038006238   ⟹   XP_037862166
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,083,197 (-)NCBI
RefSeq Acc Id: XM_038006239   ⟹   XP_037862167
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,081,730 (-)NCBI
RefSeq Acc Id: XM_038006240   ⟹   XP_037862168
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,081,741 (-)NCBI
RefSeq Acc Id: XM_038006242   ⟹   XP_037862170
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,081,174 (-)NCBI
RefSeq Acc Id: XM_038006243   ⟹   XP_037862171
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604544,751,652 - 45,239,417 (-)NCBI
RefSeq Acc Id: XP_007969049   ⟸   XM_007970858
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037862171   ⟸   XM_038006243
- Peptide Label: isoform X6
RefSeq Acc Id: XP_037862157   ⟸   XM_038006229
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037862158   ⟸   XM_038006230
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037862159   ⟸   XM_038006231
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037862163   ⟸   XM_038006235
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037862160   ⟸   XM_038006232
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037862162   ⟸   XM_038006234
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037862164   ⟸   XM_038006236
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037862166   ⟸   XM_038006238
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037862168   ⟸   XM_038006240
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037862167   ⟸   XM_038006239
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037862161   ⟸   XM_038006233
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037862170   ⟸   XM_038006242
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037862165   ⟸   XM_038006237
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
NCBI Gene SLC8A1 ENTREZGENE