| 620639 | Slc7a5 | solute carrier family 7 member 5 | ENCODES a protein that exhibits amino acid transmembrane transporter activity; antiporter activity (ortholog); aromatic amino acid transmembrane transporter activity (ortholog); INVOLVED IN amino acid import across plasma membrane; cellular response to amino acid stimulus; cellular response to gluco se starvation; PARTICIPATES IN mTOR signaling pathway; amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury; Endotoxemia; Experimental Liver Neoplasms; FOUND IN apical plasma membrane; basal plasma membrane; basolateral plasma membrane; INTERACTS WITH 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene; 17alpha-ethynylestradiol; 17beta-estradiol | 19 | 66843808 | 66872412 | Rat | 494 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733672 | Slc7a5 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | Enables L-amino acid transmembrane transporter activity. Involved in L-leucine transport. Acts upstream of or within L-amino acid transport. Located in plasma membrane. Is expressed in several structures, including central nervous system; cochlea; early conceptus; limb; and reproductive system. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to human SLC7A5 (solute carrier family 7 member 5). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 122607885 | 122634425 | Mouse | 541 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1354186 | SLC7A5 | solute carrier family 7 member 5 | Enables L-amino acid transmembrane transporter activity and secondary active transmembrane transporter activity. Involved in carboxylic acid transport; thyroid hormone transport; and xenobiotic transport. Located in several cellular components, including apical plasma membrane; cytosol; and microvil lus membrane. Part of amino acid transport complex. Implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Biomarker of esophagitis; gastrointestinal system cancer (multiple); malignant astrocytoma (multiple); and respiratory system cancer (multiple). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 87830023 | 87869507 | Human | 485 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8787312 | Slc7a5 | solute carrier family 7 member 5 | ENCODES a protein that exhibits amino acid transmembrane transporter activity (ortholog); antiporter activity (ortholog); aromatic amino acid transmembrane transporter activity (ortholog); INVOLVED IN alanine transport (ortholog); amino acid import across plasma membrane (ortholog); cellular respons e to amino acid stimulus (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); allergic contact dermatitis (ortholog); autism spectrum disorder (ortholog); FOUND IN amino acid transport complex (ortholog); apical plasma membrane (ortholog); basal plasma membrane (ortholog) | NW_004955541 | 2103437 | 2129668 | Chinchilla | 146 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12038197 | SLC7A5 | solute carrier family 7 member 5 | ENCODES a protein that exhibits amino acid transmembrane transporter activity (ortholog); antiporter activity (ortholog); aromatic amino acid transmembrane transporter activity (ortholog); INVOLVED IN alanine transport (ortholog); amino acid import across plasma membrane (ortholog); cellular respons e to amino acid stimulus (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); allergic contact dermatitis (ortholog); autism spectrum disorder (ortholog); FOUND IN amino acid transport complex (ortholog); apical plasma membrane (ortholog); basal plasma membrane (ortholog) | 16 | 68512407 | 68552763 | Bonobo | 146 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12247807 | SLC7A5 | solute carrier family 7 member 5 | ENCODES a protein that exhibits amino acid transmembrane transporter activity (inferred); antiporter activity (inferred); aromatic amino acid transmembrane transporter activity (inferred); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to glucose starvation (ortho log); cellular response to L-arginine (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); allergic contact dermatitis (ortholog); autism spectrum disorder (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | 5 | 65313105 | 65343858 | Dog | 141 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12466037 | Slc7a5 | solute carrier family 7 member 5 | ENCODES a protein that exhibits amino acid transmembrane transporter activity (ortholog); antiporter activity (ortholog); aromatic amino acid transmembrane transporter activity (ortholog); INVOLVED IN alanine transport (ortholog); amino acid import across plasma membrane (ortholog); cellular respons e to amino acid stimulus (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); allergic contact dermatitis (ortholog); autism spectrum disorder (ortholog); FOUND IN amino acid transport complex (ortholog); apical plasma membrane (ortholog); basal plasma membrane (ortholog) | NW_004936641 | 1513110 | 1538955 | Squirrel | 150 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626092436 | Slc7a5 | solute carrier family 7 member 5 | ENCODES a protein that exhibits amino acid transmembrane transporter activity (ortholog); antiporter activity (ortholog); aromatic amino acid transmembrane transporter activity (ortholog); INVOLVED IN alanine transport (ortholog); amino acid import across plasma membrane (ortholog); cellular respons e to amino acid stimulus (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); allergic contact dermatitis (ortholog); autism spectrum disorder (ortholog); FOUND IN amino acid transport complex (ortholog); apical plasma membrane (ortholog); basal plasma membrane (ortholog) | | | | Black Rat | 146 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256957 | slc7a5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18485944 | SLC7A5 | solute carrier family 7 member 5 | ENCODES a protein that exhibits amino acid transmembrane transporter activity (inferred); antiporter activity (inferred); aromatic amino acid transmembrane transporter activity (inferred); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to glucose starvation (ortho log); cellular response to L-arginine (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); allergic contact dermatitis (ortholog); autism spectrum disorder (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | | | | Green Monkey | 140 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 15039257 | SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | | | | | Pig | | symbol | gene, protein-coding |
| 14253553 | SLC7A5 | solute carrier family 7 member 5 | ENCODES an ncrna that exhibits amino acid transmembrane transporter activity (inferred); antiporter activity (inferred); aromatic amino acid transmembrane transporter activity (inferred); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to glucose starvation (orthol og); cellular response to L-arginine (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); allergic contact dermatitis (ortholog); autism spectrum disorder (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | | | | Pig | 141 | symbol | gene, ncrna, MODEL [RefSeq] |
| 18911465 | Slc7a5 | solute carrier family 7 member 5 | ENCODES a protein that exhibits amino acid transmembrane transporter activity (ortholog); antiporter activity (ortholog); aromatic amino acid transmembrane transporter activity (ortholog); INVOLVED IN alanine transport (ortholog); amino acid import across plasma membrane (ortholog); cellular respons e to amino acid stimulus (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); allergic contact dermatitis (ortholog); autism spectrum disorder (ortholog); FOUND IN amino acid transport complex (ortholog); apical plasma membrane (ortholog); basal plasma membrane (ortholog) | | | | Naked Mole-Rat | 150 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256958 | slc7a5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250702 | slc7a5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 151675150 | SLC7A5-AS1 | SLC7A5 antisense RNA 1 | | 16 | 87836265 | 87837687 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16562760 | AC126696.2 | novel transcript, antisense to SLC7A5 | | | | | Human | | name | gene, lncrna |
| 1603607 | SLC7A5P1 | solute carrier family 7 member 5 pseudogene 1 | This locus represents a pseudogene of the L-type amino acid transporter 1. Transcripts initiating at this locus read through to downstream SMG1 pseudogene 2 (SMG1P2). [provided by RefSeq, Feb 2016] | 16 | 29613103 | 29613725 | Human | 12 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1601796 | SLC7A5P2 | solute carrier family 7 member 5 pseudogene 2 | Predicted to enable transmembrane transporter activity. Predicted to be involved in L-alpha-amino acid transmembrane transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 21517893 | 21520444 | Human | 18 | symbol , COSMIC , Human Proteome Map | gene, pseudo, PROVISIONAL [RefSeq] |