| 1307517 | Sesn1 | sestrin 1 | ENCODES a protein that exhibits L-leucine binding (ortholog); INVOLVED IN cellular oxidant detoxification (ortholog); cellular response to amino acid starvation (ortholog); cellular response to amino acid stimulus (ortholog); PARTICIPATES IN p53 signaling pathway; FOUND IN cytoplasm (ortholog); fibr illar center (ortholog); GATOR2 complex (ortholog); INTERACTS WITH (S)-colchicine; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol | 20 | 46876918 | 46970010 | Rat | 227 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1316757 | SESN1 | sestrin 1 | This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] | 6 | 108984309 | 109094846 | Human | 214 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1316758 | Sesn1 | sestrin 1 | Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in cellular response to amino acid stimulus; negative regulation of TORC1 signaling; and negative regulation of cell growth. Acts upstream of or within regulation of phosphatidylinosi tol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human SESN1 (sestrin 1). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 41686570 | 41784432 | Mouse | 250 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9046128 | Sesn1 | sestrin 1 | ENCODES a protein that exhibits L-leucine binding (ortholog); INVOLVED IN cellular oxidant detoxification (ortholog); cellular response to amino acid starvation (ortholog); cellular response to amino acid stimulus (ortholog); FOUND IN cytoplasm (ortholog); fibrillar center (ortholog); GATOR2 complex (ortholog) | NW_004955411 | 34033986 | 34051171 | Chinchilla | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11712975 | SESN1 | sestrin 1 | ENCODES a protein that exhibits L-leucine binding (inferred); oxidoreductase activity (inferred); oxidoreductase activity, acting on peroxide as acceptor (inferred); INVOLVED IN regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); FOUND IN cytoplasm (inferred) ; fibrillar center (inferred); GATOR2 complex (inferred) | 6 | 106789911 | 106896382 | Bonobo | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12064175 | SESN1 | sestrin 1 | ENCODES a protein that exhibits L-leucine binding (inferred); oxidoreductase activity (inferred); INVOLVED IN regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); FOUND IN cytoplasm (inferred); fibrillar center (inferred); GATOR2 complex (inferred); INTERACTS WITH bisphenol A | 12 | 65958995 | 66057369 | Dog | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12669548 | Sesn1 | sestrin 1 | ENCODES a protein that exhibits L-leucine binding (inferred); oxidoreductase activity (inferred); oxidoreductase activity, acting on peroxide as acceptor (inferred); INVOLVED IN regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); FOUND IN cytoplasm (inferred) ; fibrillar center (inferred); GATOR2 complex (inferred) | NW_004936564 | 5187152 | 5291201 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18739074 | SESN1 | sestrin 1 | ENCODES a protein that exhibits L-leucine binding (inferred); oxidoreductase activity (inferred); oxidoreductase activity, acting on peroxide as acceptor (inferred); INVOLVED IN regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); FOUND IN cytoplasm (inferred) ; fibrillar center (inferred); GATOR2 complex (inferred) | | | | Green Monkey | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14121974 | SESN1 | sestrin 1 | ENCODES a protein that exhibits L-leucine binding (inferred); oxidoreductase activity (inferred); INVOLVED IN regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); FOUND IN cytoplasm (inferred); fibrillar center (inferred); GATOR2 complex (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928545 | Sesn1 | sestrin 1 | ENCODES a protein that exhibits L-leucine binding (inferred); oxidoreductase activity (inferred); oxidoreductase activity, acting on peroxide as acceptor (inferred); INVOLVED IN cellular oxidant detoxification (ortholog); cellular response to amino acid starvation (ortholog); cellular response to gl ucose starvation (ortholog); FOUND IN fibrillar center (ortholog); GATOR2 complex (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625885865 | Sesn1 | sestrin 1 | ENCODES a protein that exhibits L-leucine binding (ortholog); INVOLVED IN cellular oxidant detoxification (ortholog); cellular response to amino acid starvation (ortholog); cellular response to amino acid stimulus (ortholog); FOUND IN cytoplasm (ortholog); fibrillar center (ortholog); GATOR2 complex (ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252984 | sesn1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155257743 | sesn1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250222 | sesn1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16566096 | AL390208.1 | novel transcript, antisense to SESN1 | | | | | Human | | name | gene, lncrna |
