Sesn1 (sestrin 1) - Rat Genome Database

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Gene: Sesn1 (sestrin 1) Chinchilla lanigera
Analyze
Symbol: Sesn1
Name: sestrin 1
RGD ID: 9046128
Description: ENCODES a protein that exhibits L-leucine binding (ortholog); INVOLVED IN cellular oxidant detoxification (ortholog); cellular response to amino acid starvation (ortholog); cellular response to amino acid stimulus (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 4 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); fibrillar center (ortholog); GATOR2 complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sestrin-1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541134,032,490 - 34,139,822 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541134,033,986 - 34,051,171 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sesn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541134,032,490 - 34,139,822 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541134,033,986 - 34,051,171 (-)NCBIChiLan1.0ChiLan1.0
SESN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386108,984,309 - 109,094,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6108,984,309 - 109,094,846 (-)EnsemblGRCh38hg38GRCh38
GRCh376109,305,512 - 109,416,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366109,414,338 - 109,521,970 (-)NCBINCBI36Build 36hg18NCBI36
Build 346109,414,339 - 109,521,970NCBI
Celera6110,053,551 - 110,161,184 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6106,874,235 - 106,981,304 (-)NCBIHuRef
CHM1_16109,570,466 - 109,678,815 (-)NCBICHM1_1
T2T-CHM13v2.06110,161,725 - 110,272,953 (-)NCBIT2T-CHM13v2.0
Sesn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391041,686,570 - 41,784,432 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1041,685,931 - 41,784,420 (+)EnsemblGRCm39 Ensembl
GRCm381041,810,574 - 41,908,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1041,809,935 - 41,908,424 (+)EnsemblGRCm38mm10GRCm38
MGSCv371041,530,380 - 41,628,242 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361041,575,864 - 41,596,839 (+)NCBIMGSCv36mm8
Celera1042,690,911 - 42,787,751 (+)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1022.77NCBI
Sesn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82046,876,918 - 46,970,010 (+)NCBIGRCr8
mRatBN7.22045,294,876 - 45,387,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2045,294,871 - 45,387,697 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2047,012,668 - 47,105,158 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02046,662,855 - 46,755,338 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02047,362,434 - 47,451,891 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02046,667,116 - 46,758,306 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2046,667,121 - 46,758,305 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02048,347,213 - 48,437,687 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42045,786,623 - 45,877,856 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12045,879,708 - 45,900,868 (+)NCBI
Celera2054,572,050 - 54,662,230 (-)NCBICelera
Cytogenetic Map20q12NCBI
SESN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25128,995,546 - 129,101,997 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16126,886,948 - 126,992,685 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06106,789,911 - 106,896,382 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16110,839,631 - 110,945,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6110,839,631 - 110,946,276 (-)Ensemblpanpan1.1panPan2
SESN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11265,958,995 - 66,057,369 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1265,960,066 - 66,057,035 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1265,777,446 - 65,875,811 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01266,840,480 - 66,939,046 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1266,840,487 - 66,939,038 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11266,191,015 - 66,289,363 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01266,039,317 - 66,137,542 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01266,311,345 - 66,409,780 (-)NCBIUU_Cfam_GSD_1.0
Sesn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946100,912,289 - 101,016,826 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365645,187,005 - 5,291,498 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365645,187,152 - 5,291,201 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SESN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl175,056,734 - 75,088,954 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1175,056,731 - 75,170,374 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2184,357,130 - 84,371,187 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SESN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11364,756,393 - 64,864,795 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1364,841,773 - 64,863,698 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604037,058,232 - 37,167,839 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sesn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624916230,348 - 332,985 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624916231,168 - 332,423 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000018103   ⟹   ENSCLAP00000017925
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541134,032,490 - 34,139,822 (-)Ensembl
RefSeq Acc Id: XM_013510807   ⟹   XP_013366261
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541134,033,986 - 34,051,171 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013366261 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017925
  ENSCLAP00000017925.1
RefSeq Acc Id: XP_013366261   ⟸   XM_013510807
- UniProtKB: A0A8C2VRT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000017925   ⟸   ENSCLAT00000018103


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012296 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000018103 ENTREZGENE
  ENSCLAT00000018103.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1290.10 UniProtKB/TrEMBL
InterPro AhpD-like UniProtKB/TrEMBL
  Sestrin UniProtKB/TrEMBL
NCBI Gene Sesn1 ENTREZGENE
PANTHER PTHR12474 UniProtKB/TrEMBL
  SESTRIN-1 UniProtKB/TrEMBL
Pfam PA26 UniProtKB/TrEMBL
Superfamily-SCOP SSF69118 UniProtKB/TrEMBL
UniProt A0A8C2VRT8 ENTREZGENE, UniProtKB/TrEMBL