| 1308035 | Rnf8 | ring finger protein 8 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); double-strand break repair (ortholog); PARTICIPATES IN ataxia telangiectas ia-mutated (ATM) signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; allethrin | 20 | 7683890 | 7708437 | Rat | 187 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1317571 | RNF8 | ring finger protein 8 | The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nucl ear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] | 6 | 37353983 | 37394734 | Human | 175 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1317572 | Rnf8 | ring finger protein 8 | Enables histone binding activity and ubiquitin protein ligase activity. Involved in DNA metabolic process; signal transduction in response to DNA damage; and sperm DNA condensation. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in central nervous system; genitourinary system; nasal cavity epithelium; and thymus primordium. Orthologous to human RNF8 (ring finger protein 8). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 29833763 | 29860638 | Mouse | 245 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8921439 | Rnf8 | ring finger protein 8 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); double-strand break repair (ortholog); PARTICIPATES IN ataxia telangiectas ia-mutated (ATM) signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog) | NW_004955437 | 5807592 | 5832213 | Chinchilla | 52 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11798416 | RNF8 | ring finger protein 8 | ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); identical protein binding (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); DNA damage response (inferred); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathw ay; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN chromosome (inferred); chromosome, telomeric region (inferred); cytoplasm (inferred) | 6 | 36918705 | 36955380 | Bonobo | 97 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12336012 | RNF8 | ring finger protein 8 | ENCODES a protein that exhibits identical protein binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN DNA repair-dependent chromatin remodeling (ortholog); double-strand break repair via nonhomologous end joining (ortholog); epigenetic regulation of gene expression (ortholog ); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN nucleoplasm (ortholog); site of double-strand break (ortholog) | 12 | 6380365 | 6415407 | Dog | 93 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12486858 | Rnf8 | ring finger protein 8 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); double-strand break repair (ortholog); PARTICIPATES IN ataxia telangiectas ia-mutated (ATM) signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog) | NW_004936476 | 22074146 | 22121286 | Squirrel | 52 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14257738 | RNF8 | ring finger protein 8 | ENCODES a protein that exhibits 14-3-3 protein binding (inferred); chromatin binding (inferred); GTPase activator activity (inferred); INVOLVED IN 7-methylguanosine mRNA capping (inferred); cell division (inferred); chromatin organization (inferred); PARTICIPATES IN ataxia telangiectasia-mutated (AT M) signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN chromosome (inferred); chromosome, telomeric region (inferred); cullin-RING ubiquitin ligase complex (inferred) | | | | Pig | 116 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18718950 | RNF8 | ring finger protein 8 | ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); identical protein binding (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); DNA damage response (inferred); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathw ay; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN chromosome (inferred); chromosome, telomeric region (inferred); cytoplasm (inferred) | | | | Green Monkey | 96 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18936510 | Rnf8 | ring finger protein 8 | ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); identical protein binding (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); DNA damage response (inferred); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathw ay; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN chromosome (inferred); chromosome, telomeric region (inferred); cytoplasm (inferred) | | | | Naked Mole-Rat | 96 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155233397 | rnf8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625908895 | Rnf8 | ring finger protein 8 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); double-strand break repair (ortholog); PARTICIPATES IN ataxia telangiectas ia-mutated (ATM) signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 52 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155233234 | rnf8.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254176 | rnf8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12436735 | Gm28043 | predicted gene, 28043 | This locus represents naturally occurring readthrough transcription between the neighboring Rnf8 (ring finger protein 8) and Cmtr1 (cap methyltransferase 1) genes on chromosome 17. The readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Jul 2015] | 17 | 29833763 | 29924953 | Mouse | | description , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 12447747 | LOC101963224 | E3 ubiquitin-protein ligase RNF8-like | | NW_004938359 | 5767 | 6389 | Squirrel | | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12578093 | LOC101972662 | E3 ubiquitin-protein ligase RNF8-like | | NW_004937952 | 17892 | 19595 | Squirrel | | name | gene, pseudo, MODEL [RefSeq] |
| 626086247 | LOC116913206 | E3 ubiquitin-protein ligase RNF8-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 12115330 | TBC1D22B | TBC1 domain family member 22B | ENCODES a protein that exhibits 14-3-3 protein binding (inferred); GTPase activator activity (inferred); INVOLVED IN regulation of cilium assembly (ortholog); INTERACTS WITH bisphenol A | 12 | 6289704 | 6367643 | Dog | 15 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1319146 | HLTF | helicase like transcription factor | This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008] | 3 | 149030063 | 149086533 | Human | 140 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1315478 | TRAF4 | TNF receptor associated factor 4 | This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] | 17 | 28744011 | 28750956 | Human | 175 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1605425 | TRAF5 | TNF receptor associated factor 5 | The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal tr ansduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] | 1 | 211326635 | 211374946 | Human | 135 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1315706 | TRAF6 | TNF receptor associated factor 6 | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein has an amino terminal RING domain which is followed by four zinc-fi nger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in antiviral innate and antigen-specific immune responses. [provided by RefSeq, Nov 2021] | 11 | 36483769 | 36510272 | Human | 420 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1322189 | TRIM2 | tripartite motif containing 2 | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions a s an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] | 4 | 153152163 | 153339317 | Human | 210 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1345175 | TRIM21 | tripartite motif containing 21 | This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four s mall RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] | 11 | 4384897 | 4393702 | Human | 153 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1350727 | TRIM24 | tripartite motif containing 24 | The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromat in and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] | 7 | 138460259 | 138589996 | Human | 208 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1351905 | TRIM4 | tripartite motif containing 4 | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternativel y spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010] | 7 | 99890403 | 99919530 | Human | 53 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1343210 | TRIM5 | tripartite motif containing 5 | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies . It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009] | 11 | 5588635 | 5685074 | Human | 138 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1316640 | TRIM6 | tripartite motif containing 6 | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. Thi s gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010] | 11 | 5596111 | 5612952 | Human | 156 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1604884 | TRIM6-TRIM34 | TRIM6-TRIM34 readthrough | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene represents a readthrough transcript from genes TRIM6 and TRIM34, and it was described as a splice variant of TRIM34. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. [provided by RefSeq, Nov 2009] | 11 | 5596637 | 5644398 | Human | 16 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
