| 621097 | Psmc1 | proteasome 26S subunit, ATPase 1 | ENCODES a protein that exhibits TBP-class protein binding; INVOLVED IN regulation of AMPA receptor activity; PARTICIPATES IN ubiquitin/proteasome degradation pathway; ASSOCIATED WITH neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (ortholog); prostate cancer (orth olog); FOUND IN synaptic vesicle; cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene; 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | 6 | 125122497 | 125134859 | Rat | 144 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734425 | PSMC1 | proteasome 26S subunit, ATPase 1 | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. T he 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008] | 14 | 90256553 | 90275429 | Human | 188 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 734426 | Psmc1 | protease (prosome, macropain) 26S subunit, ATPase 1 | Predicted to enable TBP-class protein binding activity and proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in several structures, including alimentary system; brain; ge nitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss. Orthologous to human PSMC1 (proteasome 26S subunit, ATPase 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 100076461 | 100089623 | Mouse | 175 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8864924 | Psmc1 | proteasome 26S subunit, ATPase 1 | ENCODES a protein that exhibits TBP-class protein binding (ortholog); INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (ortholog); prostate cancer (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); proteasome accessory complex (ortholog) | NW_004955438 | 12705328 | 12721050 | Chinchilla | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11720595 | PSMC1 | proteasome 26S subunit, ATPase 1 | ENCODES a protein that exhibits TBP-class protein binding (ortholog); INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (ortholog); prostate cancer (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); proteasome accessory complex (ortholog) | 14 | 70873846 | 70889988 | Bonobo | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12408332 | PSMC1 | proteasome 26S subunit, ATPase 1 | ENCODES a protein that exhibits TBP-class protein binding (ortholog); INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (ortholog); prostate cancer (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); proteasome accessory complex (ortholog) | 8 | 61272363 | 61285886 | Dog | 40 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12484909 | Psmc1 | proteasome 26S subunit, ATPase 1 | ENCODES a protein that exhibits TBP-class protein binding (ortholog); INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (ortholog); prostate cancer (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); proteasome accessory complex (ortholog) | NW_004936488 | 17455612 | 17468933 | Squirrel | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13898097 | PSMC1 | proteasome 26S subunit, ATPase 1 | ENCODES a protein that exhibits TBP-class protein binding (ortholog); INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (ortholog); prostate cancer (ortholog); FOUND IN synaptic vesicle (or tholog) | | | | Pig | 43 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 626157005 | Psmc1 | proteasome 26S subunit, ATPase 1 | ENCODES a protein that exhibits TBP-class protein binding (ortholog); INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (ortholog); prostate cancer (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); proteasome accessory complex (ortholog) | | | | Black Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259125 | psmc1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18914608 | Psmc1 | proteasome 26S subunit, ATPase 1 | ENCODES a protein that exhibits TBP-class protein binding (ortholog); INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (ortholog); prostate cancer (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); proteasome accessory complex (ortholog) | | | | Naked Mole-Rat | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18364010 | PSMC1 | proteasome 26S subunit, ATPase 1 | ENCODES a protein that exhibits TBP-class protein binding (ortholog); INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (ortholog); prostate cancer (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); proteasome accessory complex (ortholog) | | | | Green Monkey | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247162 | psmc1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256970 | psmc1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 15038193 | Psmc1-rs1 | protease (prosome, macropain) 26S subunit, ATPase 1, related sequence 1 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 1348724 | PSMC1P1 | proteasome 26S subunit, ATPase 1 pseudogene 1 | INTERACTS WITH lead diacetate | 3 | 68635707 | 68637247 | Human | 1 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 5130613 | PSMC1P2 | proteasome 26S subunit, ATPase 1 pseudogene 2 | | 7 | 27461711 | 27463189 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130615 | PSMC1P3 | proteasome 26S subunit, ATPase 1 pseudogene 3 | | 7 | 136713873 | 136715412 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130618 | PSMC1P4 | proteasome 26S subunit, ATPase 1 pseudogene 4 | | 5 | 56275075 | 56276626 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10412462 | PSMC1P5 | proteasome 26S subunit, ATPase 1 pseudogene 5 | | 5 | 107195156 | 107195332 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130602 | PSMC1P6 | proteasome 26S subunit, ATPase 1 pseudogene 6 | | 3 | 87630078 | 87631623 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130600 | PSMC1P7 | proteasome 26S subunit, ATPase 1 pseudogene 7 | INTERACTS WITH propanal | 3 | 161328705 | 161330236 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130616 | PSMC1P8 | proteasome 26S subunit, ATPase 1 pseudogene 8 | | 12 | 17383113 | 17384645 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130445 | PSMC1P9 | proteasome 26S subunit, ATPase 1 pseudogene 9 | INTERACTS WITH tunicamycin | 12 | 18692759 | 18694323 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130617 | PSMC1P10 | proteasome 26S subunit, ATPase 1 pseudogene 10 | | 2 | 17385093 | 17386634 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130614 | PSMC1P11 | proteasome 26S subunit, ATPase 1 pseudogene 11 | | 6 | 4702457 | 4704003 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130601 | PSMC1P12 | proteasome 26S subunit, ATPase 1 pseudogene 12 | | 1 | 118614107 | 118615644 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130571 | PSMC1P13 | proteasome 26S subunit, ATPase 1 pseudogene 13 | | 13 | 69893856 | 69895367 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
