| 621092 | Psmb1 | proteasome 20S subunit beta 1 | INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); regulation of proteasomal protein catabolic process (ortholog); PARTICIPATES IN ubiquitin/proteasome degradation pathway; ASSOCIATED WITH Acute Coronary Syndrom e (ortholog); Desbuquois dysplasia (ortholog); NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, AND ABSENT LANGUAGE (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dinitrobenzene; 17alpha-ethynylestradiol | 1 | 65115770 | 65136516 | Rat | 186 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733154 | PSMB1 | proteasome 20S subunit beta 1 | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throug hout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008] | 6 | 170535120 | 170553307 | Human | 285 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 733155 | Psmb1 | proteasome (prosome, macropain) subunit, beta type 1 | Predicted to be involved in proteolysis involved in protein catabolic process. Part of proteasome core complex. Is expressed in central nervous system; dorsal root ganglion; integumental system; rib; and sensory organ. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 15695983 | 15718538 | Mouse | 181 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9017232 | Psmb1 | proteasome 20S subunit beta 1 | INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); regulation of proteasomal protein catabolic process (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Desbuquois dysplasia (ortholog); NEURODEVELO PMENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, AND ABSENT LANGUAGE (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955411 | 3285610 | 3304210 | Chinchilla | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11890221 | PSMB1 | proteasome 20S subunit beta 1 | INVOLVED IN proteasomal protein catabolic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); proteolysis involved in protein catabolic process (inferred); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Desbuquois dysplasia (ortholog); NEURODEVELOPM ENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, AND ABSENT LANGUAGE (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | 6 | 168695047 | 168713257 | Bonobo | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12052737 | PSMB1 | proteasome 20S subunit beta 1 | INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); regulation of proteasomal protein catabolic process (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Desbuquois dysplasia (ortholog); NEURODEVELO PMENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, AND ABSENT LANGUAGE (ortholog); FOUND IN nucleoplasm (ortholog) | 12 | 72440224 | 72456304 | Dog | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12736445 | Psmb1 | proteasome 20S subunit beta 1 | INVOLVED IN proteasomal protein catabolic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); proteolysis involved in protein catabolic process (inferred); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Desbuquois dysplasia (ortholog); NEURODEVELOPM ENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, AND ABSENT LANGUAGE (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004937098 | 67298 | 80019 | Squirrel | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13846930 | PSMB1 | proteasome 20S subunit beta 1 | INVOLVED IN proteasomal protein catabolic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); proteolysis involved in protein catabolic process (inferred); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Desbuquois dysplasia (ortholog); NEURODEVELOPM ENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, AND ABSENT LANGUAGE (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 40 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18551452 | PSMB1 | proteasome 20S subunit beta 1 | INVOLVED IN proteasomal protein catabolic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); proteolysis involved in protein catabolic process (inferred); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Desbuquois dysplasia (ortholog); NEURODEVELOPM ENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, AND ABSENT LANGUAGE (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920875 | Psmb1 | proteasome 20S subunit beta 1 | INVOLVED IN proteasomal protein catabolic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); proteolysis involved in protein catabolic process (inferred); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Desbuquois dysplasia (ortholog); NEURODEVELOPM ENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, AND ABSENT LANGUAGE (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232913 | psmb1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625906785 | Psmb1 | proteasome 20S subunit beta 1 | INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); regulation of proteasomal protein catabolic process (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Desbuquois dysplasia (ortholog); NEURODEVELO PMENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, AND ABSENT LANGUAGE (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405858069 | psmb1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859427 | psmb1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864055 | psmb1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865073 | psmb1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626180399 | psmb1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626185179 | psmb1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236908 | psmb1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16554414 | AC092580.1 | proteasome (prosome, macropain) subunit, beta type, 1 (PSMB1) pseudogene | | 2 | 7736439 | 7737095 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16555494 | AC092580.3 | pseudogene similar to part of proteasome (prosome, macropain) subunit, beta type, 1 (PSMB1) | | | | | Human | | name | gene, processed_pseudogene |
| 1307428 | Psmb10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); PARTICIPATES IN ubiquitin/proteasome degradation pathway; ASSOCIATED WITH Experimen tal Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN proteasome core complex (ortholog); spermatoproteasome complex (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol | 19 | 50740808 | 50743292 | Rat | 192 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1316619 | PSMB10 | proteasome 20S subunit beta 10 | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throug hout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008] | 16 | 67934506 | 67936850 | Human | 265 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1316620 | Psmb10 | proteasome (prosome, macropain) subunit, beta type 10 | Predicted to enable endopeptidase activity. Acts upstream of or within T cell proliferation and cell morphogenesis. Part of proteasome core complex and spermatoproteasome complex. Is expressed in several structures, including adrenal gland; cerebral cortex; genitourinary system; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in immunodeficiency 121 and proteosome-associated autoinflammatory syndrome 5. Orthologous to human PSMB10 (proteasome 20S subunit beta 10). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 106662360 | 106665024 | Mouse | 226 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9004067 | Psmb10 | proteasome 20S subunit beta 10 | INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN proteasome core complex (ortholog); spermatoproteasome complex (o rtholog) | NW_004955484 | 8777618 | 8780393 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11729096 | PSMB10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | 16 | 48275764 | 48278108 | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12203000 | PSMB10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | 5 | 81560750 | 81563571 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12717171 | Psmb10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | NW_004936475 | 18290055 | 18293035 | Squirrel | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14296879 | PSMB10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | | | | Pig | 26 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18448519 | PSMB10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907195 | Psmb10 | proteasome 20S subunit beta 10 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); proteasome complex (inferred) | | | | Naked Mole-Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625836465 | Psmb10 | proteasome 20S subunit beta 10 | INVOLVED IN cell morphogenesis (ortholog); T cell proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); human immunodeficiency virus infectious disease (ortholog); immunodeficiency 121 (ortholog); FOUND IN proteasome core complex (ortholog); spermatoproteasome complex (o rtholog) | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1308773 | Psmb11 | proteasome subunit beta 11 | ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN CD8-positive, alpha-beta T cell differentiation (ortholog); proteolysis (ortholog); T cell differentiation in thymus (ortholog); PARTICIPATES IN ubiquitin/proteasome degradation pathway; FOUND IN proteasome core complex (orth olog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide | 15 | 32054747 | 32055666 | Rat | 39 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1318742 | Psmb11 | proteasome (prosome, macropain) subunit, beta type, 11 | Predicted to enable endopeptidase activity. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation and T cell differentiation in thymus. Part of proteasome core complex. Is expressed in thymus and thymus cortex epithelium. Orthologous to human PSMB1 1 (proteasome subunit beta 11). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 54862767 | 54867013 | Mouse | 81 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2291820 | PSMB11 | proteasome subunit beta 11 | Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008] | 14 | 23042212 | 23044060 | Human | 50 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8736581 | Psmb11 | proteasome subunit beta 11 | ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN CD8-positive, alpha-beta T cell differentiation (ortholog); proteolysis (ortholog); T cell differentiation in thymus (ortholog); FOUND IN proteasome core complex (ortholog) | NW_004955409 | 37260080 | 37260866 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11688925 | PSMB11 | proteasome subunit beta 11 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN CD8-positive, alpha-beta T cell differentiation (ortholog); proteolysis (ortholog); T cell differentiation in thymus (ortholog); FOUND IN cytopl asm (inferred); nucleus (inferred); proteasome complex (inferred) | 14 | 3861823 | 3863949 | Bonobo | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12339443 | PSMB11 | proteasome subunit beta 11 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN CD8-positive, alpha-beta T cell differentiation (ortholog); proteolysis (ortholog); T cell differentiation in thymus (ortholog); FOUND IN cytopl asm (inferred); nucleus (inferred); proteasome complex (inferred) | 8 | 3355239 | 3356505 | Dog | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12455259 | Psmb11 | proteasome subunit beta 11 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN CD8-positive, alpha-beta T cell differentiation (ortholog); proteolysis (ortholog); T cell differentiation in thymus (ortholog); FOUND IN cytopl asm (inferred); nucleus (inferred); proteasome complex (inferred) | NW_004936722 | 1279867 | 1281232 | Squirrel | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14265870 | PSMB11 | proteasome subunit beta 11 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN CD8-positive, alpha-beta T cell differentiation (ortholog); proteolysis (ortholog); T cell differentiation in thymus (ortholog); FOUND IN cytopl asm (inferred); nucleus (inferred); proteasome complex (inferred) | | | | Pig | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18618445 | PSMB11 | proteasome subunit beta 11 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN CD8-positive, alpha-beta T cell differentiation (ortholog); proteolysis (ortholog); T cell differentiation in thymus (ortholog); FOUND IN cytopl asm (inferred); nucleus (inferred); proteasome complex (inferred) | | | | Green Monkey | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18909381 | Psmb11 | proteasome subunit beta 11 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN CD8-positive, alpha-beta T cell differentiation (ortholog); proteolysis (ortholog); T cell differentiation in thymus (ortholog); FOUND IN cytopl asm (inferred); nucleus (inferred); proteasome complex (inferred) | | | | Naked Mole-Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 39131444 | PSMB11 | proteasome subunit beta 11 | | | | | Chinchilla | | symbol | gene, protein-coding |
| 155247931 | psmb11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626032539 | Psmb11 | proteasome subunit beta 11 | ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN CD8-positive, alpha-beta T cell differentiation (ortholog); proteolysis (ortholog); T cell differentiation in thymus (ortholog); FOUND IN proteasome core complex (ortholog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247932 | psmb11.L | | | | | | African Clawed Frog | | symbol | gene, null |