| 620961 | Prkci | protein kinase C, iota | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); phospholipid binding (ortholog); protein kinase activity (ortholog); INVOLVED IN cell migration; cellular response to insulin stimulus; Golgi vesicle budding; PARTICIPATES IN in sulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus; abdominal obesity-metabolic syndrome (ortholog); autistic disorder (ortholog); FOUND IN bicellular tight junction; cell leading edge; glutamatergic synapse; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid | 2 | 114250398 | 114310784 | Rat | 218 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732937 | PRKCI | protein kinase C iota | This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholip id-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008] | 3 | 170222424 | 170305977 | Human | 228 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1331958 | Prkci | protein kinase C, iota | Enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity. Involved in cellular response to insulin stimulus; positive regulation of D-glucose import; and positive regulation of protein localization to plasma membrane. Acts upstream of or within actin filament organizati on; establishment of apical/basal cell polarity; and eye photoreceptor cell development. Located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and brush border. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Used to study abdominal obesity-metabolic syndrome; obesity; and type 2 diabetes mellitus. Orthologous to human PRKCI (protein kinase C iota). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 31049893 | 31106889 | Mouse | 322 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8987140 | Prkci | protein kinase C iota | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); phospholipid binding (ortholog); protein kinase activity (ortholog); INVOLVED IN actin filament organization (ortholog); cell migration (ortholog); cell-cell junction organizati on (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); autistic disorder (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); bicellular tight junction (ortholog) | NW_004955420 | 423406 | 486676 | Chinchilla | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11775551 | PRKCI | protein kinase C iota | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); INVOLVED IN actin filament organization (ortholog); cell migration (ortholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); autistic disorder (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); bicellular tight junction (ortholog) | 3 | 167237093 | 167320522 | Bonobo | 92 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12320329 | PRKCI | protein kinase C iota | ENCODES a protein that exhibits ATP binding (inferred); diacylglycerol-dependent serine/threonine kinase activity (inferred); diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (inferred); INVOLVED IN actin filament organization (ortholog); cell migration (ortholog); cell ular response to insulin stimulus (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); autistic disorder (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN bicellular tight junction (ortholog); cell leading edge (ortholog); glutamatergic synapse (ortholog) | 34 | 34767066 | 34839823 | Dog | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12625511 | Prkci | protein kinase C iota | ENCODES a protein that exhibits ATP binding (inferred); diacylglycerol-dependent serine/threonine kinase activity (inferred); diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (inferred); INVOLVED IN actin filament organization (ortholog); cell migration (ortholog); cell ular response to insulin stimulus (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); autistic disorder (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN bicellular tight junction (ortholog); cell leading edge (ortholog); glutamatergic synapse (ortholog) | NW_004936593 | 2170539 | 2236904 | Squirrel | 89 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243048 | prkci | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18610273 | PRKCI | protein kinase C iota | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); phospholipid binding (ortholog); protein kinase activity (ortholog); INVOLVED IN actin filament organization (ortholog); cell migration (ortholog); cell-cell junction organizati on (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); autistic disorder (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); bicellular tight junction (ortholog) | | | | Green Monkey | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866908 | PRKCI | protein kinase C iota | ENCODES a protein that exhibits ATP binding (inferred); diacylglycerol-dependent serine/threonine kinase activity (inferred); diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (inferred); INVOLVED IN cell-cell junction organization (inferred); cellular response to insuli n stimulus (inferred); establishment or maintenance of epithelial cell apical/basal polarity (inferred); FOUND IN apical part of cell (inferred); apical plasma membrane (inferred); brush border (inferred) | | | | Green Monkey | 36 | symbol | gene, protein-coding |
| 13847474 | PRKCI | protein kinase C iota | ENCODES a protein that exhibits ATP binding (inferred); diacylglycerol-dependent serine/threonine kinase activity (inferred); diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (inferred); INVOLVED IN actin filament organization (ortholog); cell migration (ortholog); cell ular response to insulin stimulus (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); autistic disorder (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN bicellular tight junction (ortholog); cell leading edge (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 96 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626125825 | Prkci | protein kinase C iota | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); phospholipid binding (ortholog); protein kinase activity (ortholog); INVOLVED IN actin filament organization (ortholog); cell migration (ortholog); cell-cell junction organizati on (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); autistic disorder (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); bicellular tight junction (ortholog) | | | | Black Rat | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18899954 | Prkci | protein kinase C iota | ENCODES a protein that exhibits diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (ortholog); phospholipid binding (ortholog); INVOLVED IN actin filament organization (ortholog); cell migration (ortholog); cell-cell junction organization (ortholog); PARTICIPATES IN insul in responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); autistic disorder (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); bicellular tight junction (ortholog) | | | | Naked Mole-Rat | 87 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242420 | prkci.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252531 | prkci.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1593411 | Hint1 | histidine triad nucleotide binding protein 1 | ENCODES a protein that exhibits adenosine 5'-monophosphoramidase activity (ortholog); deSUMOylase activity (ortholog); hydrolase activity (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); positive regulation of calcium-mediated signaling (ortholog); prot ein desumoylation (ortholog); ASSOCIATED WITH axonal neuropathy (ortholog); Charcot-Marie-Tooth disease (ortholog); Gamstorp-Wohlfart syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); histone deacetylase complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrolein | 10 | 39490225 | 39493970 | Rat | 169 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620960 | Hint1-ps1 | histidine triad nucleotide binding protein 1, pseudogene 1 | INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 4 | 93430947 | 93431521 | Rat | 6 | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 27375537 | PRKCIP1 | PRKCI pseudogene 1 | | X | 101534636 | 101539446 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16556924 | PRKCIP1 | PRKCI pseudogene 1 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
