| 735090 | Prickle1 | prickle planar cell polarity protein 1 | ENCODES a protein that exhibits transcription factor binding; protein-containing complex binding (ortholog); INVOLVED IN protein import into nucleus; animal organ morphogenesis (ortholog); anterior visceral endoderm cell migration (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity p athway; Wnt signaling pathway; ASSOCIATED WITH Experimental Seizures; temporal lobe epilepsy; autism spectrum disorder (ortholog); FOUND IN cell trailing edge (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; all-trans-retinoic acid | 7 | 126518587 | 126614581 | Rat | 298 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1346789 | PRICKLE1 | prickle planar cell polarity protein 1 | This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have b een linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009] | 12 | 42456757 | 42589746 | Human | 300 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1618248 | Prickle1 | prickle planar cell polarity protein 1 | Predicted to enable zinc ion binding activity. Involved in several processes, including embryonic morphogenesis; extracellular matrix organization; and plasma membrane bounded cell projection organization. Acts upstream of or within aorta development and coronary vasculature development. Located in nucleus. Part of proteasome complex. Is active in several cellular components, including cell trailing edge; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; limb; and sensory organ. Used to study autism spectrum disorder; autosomal recessive Robinow syndrome; progressive myoclonus epilepsy 1B; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 93396992 | 93494147 | Mouse | 340 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8853213 | Prickle1 | prickle planar cell polarity protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); transcription factor binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior visceral endoderm cell migration (ortholog); aorta development (ortholog); PARTICIPATES IN Wnt signaling, the planar cel l polarity pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive Robinow syndrome (ortholog); benign epilepsy with centrotemporal spikes (ortholog); FOUND IN cell trailing edge (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | NW_004955500 | 1897899 | 1990791 | Chinchilla | 120 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11914876 | PRICKLE1 | prickle planar cell polarity protein 1 | ENCODES a protein that exhibits transcription factor binding (ortholog); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); protein import into nucleus (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH autism spectrum dis order (ortholog); autosomal recessive Robinow syndrome (ortholog); benign epilepsy with centrotemporal spikes (ortholog); FOUND IN proteasome complex (ortholog) | 12 | 46127673 | 46262333 | Bonobo | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12410056 | PRICKLE1 | prickle planar cell polarity protein 1 | ENCODES a protein that exhibits transcription factor binding (ortholog); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); protein import into nucleus (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH autism spectrum dis order (ortholog); autosomal recessive Robinow syndrome (ortholog); benign epilepsy with centrotemporal spikes (ortholog); FOUND IN proteasome complex (ortholog) | 27 | 11327086 | 11437799 | Dog | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12735926 | Prickle1 | prickle planar cell polarity protein 1 | ENCODES a protein that exhibits transcription factor binding (ortholog); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); protein import into nucleus (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH autism spectrum dis order (ortholog); autosomal recessive Robinow syndrome (ortholog); benign epilepsy with centrotemporal spikes (ortholog); FOUND IN proteasome complex (ortholog) | NW_004936512 | 1165159 | 1270138 | Squirrel | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256816 | prickle1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18905882 | Prickle1 | prickle planar cell polarity protein 1 | ENCODES a protein that exhibits transcription factor binding (ortholog); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); protein import into nucleus (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH autism spectrum dis order (ortholog); autosomal recessive Robinow syndrome (ortholog); benign epilepsy with centrotemporal spikes (ortholog); FOUND IN proteasome complex (ortholog) | | | | Naked Mole-Rat | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626016851 | Prickle1 | prickle planar cell polarity protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); transcription factor binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior visceral endoderm cell migration (ortholog); aorta development (ortholog); PARTICIPATES IN Wnt signaling, the planar cel l polarity pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive Robinow syndrome (ortholog); benign epilepsy with centrotemporal spikes (ortholog); FOUND IN cell trailing edge (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 117 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14195406 | PRICKLE1 | prickle planar cell polarity protein 1 | ENCODES a protein that exhibits transcription factor binding (ortholog); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); protein import into nucleus (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH autism spectrum dis order (ortholog); autosomal recessive Robinow syndrome (ortholog); benign epilepsy with centrotemporal spikes (ortholog); FOUND IN proteasome complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 109 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18415942 | PRICKLE1 | prickle planar cell polarity protein 1 | ENCODES a protein that exhibits transcription factor binding (ortholog); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); protein import into nucleus (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH autism spectrum dis order (ortholog); autosomal recessive Robinow syndrome (ortholog); benign epilepsy with centrotemporal spikes (ortholog); FOUND IN proteasome complex (ortholog) | | | | Green Monkey | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257745 | prickle1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248124 | prickle1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 616940490 | PRICKLE1-AS1 | PRICKLE1 antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 38661407 | PRICKLE1P1 | PRICKLE1 pseudogene 1 | | 3 | 183613564 | 183615266 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16561234 | AC079601.1 | novel transcript, antisense to PRICKLE1 | | | | | Human | | name | gene, lncrna |
| 16561523 | AC079600.3 | novel transcript, sense intronic to PRICKLE1 | | | | | Human | | name | gene, lncrna |
| 16557782 | AC068769.1 | prickle homolog 1 (Drosophila) (PRICKLE1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
