| 620907 | Ppp2r1a | protein phosphatase 2 scaffold subunit A alpha | ENCODES a protein that exhibits protein antigen binding (ortholog); protein heterodimerization activity (ortholog); protein phosphatase regulator activity (ortholog); INVOLVED IN chromosome segregation (ortholog); female meiotic nuclear division (ortholog); meiotic sister chromatid cohesion, centrom eric (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; platelet-derived growth factor signaling pathway; Chagas disease pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 36 (ortholog); Disease Progression (ortholog); FOUND IN chromatin (ortholog); chromosome, centromeric region (ortholog); cytosol (ortholog); INTERACTS WITH (R)-adrenaline; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether | 1 | 69213198 | 69232441 | Rat | 188 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1345219 | PPP2R1A | protein phosphatase 2 scaffold subunit Aalpha | This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic s ubunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010] | 19 | 52190052 | 52229518 | Human | 331 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1550262 | Ppp2r1a | protein phosphatase 2, regulatory subunit A, alpha | Enables protein serine/threonine phosphatase activity. Involved in T cell homeostasis and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within several processes, including nuclear division; peptidyl-serine dephosphorylation; and positi ve regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol. Part of protein phosphatase type 2A complex. Is active in glutamatergic synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 21165716 | 21186167 | Mouse | 239 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8719720 | Ppp2r1a | protein phosphatase 2 scaffold subunit Aalpha | ENCODES a protein that exhibits protein antigen binding (ortholog); protein heterodimerization activity (ortholog); protein phosphatase regulator activity (ortholog); INVOLVED IN chromosome segregation (ortholog); female meiotic nuclear division (ortholog); meiotic sister chromatid cohesion, centrom eric (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 36 (ortholog); Disease Progression (ortholog); FOUND IN chromatin (ortholog); chromosome, centromeric region (ortholog); cytosol (ortholog) | NW_004955558 | 381794 | 410485 | Chinchilla | 111 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11943526 | PPP2R1A | protein phosphatase 2 scaffold subunit Aalpha | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN female meiotic nuclear division (ortholog); meiotic sister chromatid cohesion, centromeric (ortholog); meiotic spindle elongation (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signal ing pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 36 (ortholog); Disease Progression (ortholog); FOUND IN glutamatergic synapse (ortholog); nucleus (ortholog); synapse (ortholog) | 19 | 49133295 | 49169447 | Bonobo | 111 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12372671 | PPP2R1A | protein phosphatase 2 scaffold subunit Aalpha | ENCODES a protein that exhibits protein antigen binding (ortholog); protein heterodimerization activity (ortholog); protein serine/threonine phosphatase activity (ortholog); INVOLVED IN chromosome segregation (ortholog); female meiotic nuclear division (ortholog); meiotic sister chromatid cohesion, centromeric (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 36 (ortholog); Disease Progression (ortholog); FOUND IN chromatin (ortholog); chromosome, centromeric region (ortholog); cytosol (ortholog) | 1 | 104974059 | 105013745 | Dog | 113 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12624746 | Ppp2r1a | protein phosphatase 2 scaffold subunit Aalpha | ENCODES a protein that exhibits protein antigen binding (inferred); protein heterodimerization activity (inferred); protein phosphatase regulator activity (inferred); INVOLVED IN female meiotic nuclear division (ortholog); meiotic sister chromatid cohesion, centromeric (ortholog); meiotic spindle el ongation (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 36 (ortholog); Disease Progression (ortholog); FOUND IN nucleus (ortholog) | NW_004936901 | 622893 | 653044 | Squirrel | 112 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13938680 | PPP2R1A | protein phosphatase 2 scaffold subunit Aalpha | ENCODES a protein that exhibits protein phosphatase regulator activity (ortholog); protein serine/threonine phosphatase activity (ortholog); INVOLVED IN chromosome segregation (ortholog); female meiotic nuclear division (ortholog); meiotic sister chromatid cohesion, centromeric (ortholog); PARTICIPA TES IN phosphatidylinositol 3-kinase-Akt signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 36 (ortholog); Disease Progression (ortholog); FOUND IN chromatin (ortholog); chromosome, centromeric region (ortholog); cytosol (ortholog) | | | | Pig | 126 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18730345 | PPP2R1A | protein phosphatase 2 scaffold subunit Aalpha | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN female meiotic nuclear division (ortholog); meiotic sister chromatid cohesion, centromeric (ortholog); meiotic spindle elongation (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signal ing pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 36 (ortholog); Disease Progression (ortholog); FOUND IN glutamatergic synapse (ortholog); nucleus (ortholog); synapse (ortholog) | | | | Green Monkey | 111 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18921076 | Ppp2r1a | protein phosphatase 2 scaffold subunit Aalpha | ENCODES a protein that exhibits protein antigen binding (ortholog); protein heterodimerization activity (ortholog); protein serine/threonine phosphatase activity (ortholog); INVOLVED IN female meiotic nuclear division (ortholog); meiotic sister chromatid cohesion, centromeric (ortholog); meiotic spi ndle elongation (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 36 (ortholog); Disease Progression (ortholog); FOUND IN chromatin (ortholog); chromosome, centromeric region (ortholog); FAR/SIN/STRIPAK complex (ortholog) | | | | Naked Mole-Rat | 110 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247884 | ppp2r1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626095548 | Ppp2r1a | protein phosphatase 2 scaffold subunit Aalpha | ENCODES a protein that exhibits protein antigen binding (ortholog); protein heterodimerization activity (ortholog); protein phosphatase regulator activity (ortholog); INVOLVED IN chromosome segregation (ortholog); female meiotic nuclear division (ortholog); meiotic sister chromatid cohesion, centrom eric (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 36 (ortholog); Disease Progression (ortholog); FOUND IN chromatin (ortholog); chromosome, centromeric region (ortholog); cytosol (ortholog) | | | | Black Rat | 106 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255849 | ppp2r1a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231387 | ppp2r1a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 597805843 | PPP2R1A-AS1 | PPP2R1A antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 7727798 | Ppp2r1a-ps1 | protein phosphatase 2 scaffold subunit A alpha, pseudogene 1 | | 15 | 44356019 | 44357770 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16564890 | AC010320.2 | novel transcript, antisense to PPP2R1A | | | | | Human | | name | gene, lncrna |
| 1310316 | Pabir1 | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | ENCODES a protein that exhibits protein phosphatase 2A binding (ortholog); protein phosphatase inhibitor activity (ortholog); protein serine/threonine phosphatase inhibitor activity (ortholog); INVOLVED IN mitotic G2/M transition checkpoint (ortholog); positive regulation of cell growth (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; azoxystrobin; bisphenol A | 1 | 231541411 | 231542717 | Rat | 68 | name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1321149 | PABIR1 | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | Enables protein phosphatase 2A binding activity and protein serine/threonine phosphatase inhibitor activity. Involved in mitotic G2/M transition checkpoint; positive regulation of cell growth; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 68780065 | 68785566 | Human | 68 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8839738 | Pabir1 | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | ENCODES a protein that exhibits protein phosphatase 2A binding (ortholog); protein phosphatase inhibitor activity (ortholog); protein serine/threonine phosphatase inhibitor activity (ortholog); INVOLVED IN mitotic G2/M transition checkpoint (ortholog); positive regulation of cell growth (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | NW_004955434 | 4250105 | 4251508 | Chinchilla | 14 | name | gene, protein-coding, MODEL [RefSeq] |
| 11822645 | PABIR1 | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | ENCODES a protein that exhibits protein phosphatase 2A binding (inferred); protein phosphatase inhibitor activity (inferred); protein serine/threonine phosphatase inhibitor activity (inferred); INVOLVED IN mitotic G2/M transition checkpoint (inferred); positive regulation of cell growth (inferred); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (inferred); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | 9 | 56007323 | 56011655 | Bonobo | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12417413 | PABIR1 | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | ENCODES a protein that exhibits protein phosphatase 2A binding (ortholog); protein phosphatase inhibitor activity (ortholog); INVOLVED IN mitotic G2/M transition checkpoint (ortholog); positive regulation of cell growth (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catab olic process (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | 1 | 88580008 | 88587037 | Dog | 14 | name | gene, protein-coding, MODEL [RefSeq] |
| 12596047 | Pabir1 | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | ENCODES a protein that exhibits protein phosphatase 2A binding (inferred); protein phosphatase inhibitor activity (inferred); protein serine/threonine phosphatase inhibitor activity (inferred); INVOLVED IN mitotic G2/M transition checkpoint (inferred); positive regulation of cell growth (inferred); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (inferred); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | NW_004936503 | 5095986 | 5097274 | Squirrel | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13856870 | PABIR1 | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | ENCODES a protein that exhibits protein phosphatase 2A binding (ortholog); protein phosphatase inhibitor activity (ortholog); protein serine/threonine phosphatase inhibitor activity (ortholog); INVOLVED IN mitotic G2/M transition checkpoint (ortholog); positive regulation of cell growth (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | | | | Pig | 14 | name | gene, protein-coding, MODEL [RefSeq] |
| 18665566 | PABIR1 | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | ENCODES a protein that exhibits protein phosphatase 2A binding (inferred); protein phosphatase inhibitor activity (inferred); protein serine/threonine phosphatase inhibitor activity (inferred); INVOLVED IN mitotic G2/M transition checkpoint (inferred); positive regulation of cell growth (inferred); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (inferred); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | | | | Green Monkey | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18935662 | Pabir1 | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | ENCODES a protein that exhibits protein phosphatase 2A binding (ortholog); protein phosphatase inhibitor activity (ortholog); INVOLVED IN mitotic G2/M transition checkpoint (ortholog); positive regulation of cell growth (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catab olic process (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 14 | name | gene, protein-coding, MODEL [RefSeq] |
| 153003046 | PABIR1 | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | ENCODES a protein that exhibits protein phosphatase 2A binding (inferred); protein phosphatase inhibitor activity (inferred); protein serine/threonine phosphatase inhibitor activity (inferred); INVOLVED IN mitotic G2/M transition checkpoint (inferred); positive regulation of cell growth (inferred); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (inferred); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | | | | Pig | 15 | name | gene, protein-coding |
| 626165055 | Pabir1 | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | ENCODES a protein that exhibits protein phosphatase 2A binding (ortholog); protein phosphatase inhibitor activity (ortholog); protein serine/threonine phosphatase inhibitor activity (ortholog); INVOLVED IN mitotic G2/M transition checkpoint (ortholog); positive regulation of cell growth (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 14 | name | gene, protein-coding, MODEL [RefSeq] |
| 1321150 | Pabir1 | PP2A A alpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in mitotic G2/M transition checkpoint; positive regulation of cell growth; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nuclear body. Is expressed in embryo. Orthologous to human PABIR1 (PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 24451270 | 24454819 | Mouse | 98 | name , description | gene, protein-coding, VALIDATED [RefSeq] |