| 1344023 | OAZ2 | ornithine decarboxylase antizyme 2 | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014] | 15 | 64687574 | 64703281 | Human | 96 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] | | 1562933 | Oaz2 | ornithine decarboxylase antizyme 2 | ENCODES a protein that exhibits ornithine decarboxylase inhibitor activity (ortholog); INVOLVED IN negative regulation of polyamine transmembrane transport (ortholog); positive regulation of intracellular protein transport (ortholog); positive regulation of protein catabolic process (ortholog); PART ICIPATES IN polyamine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol | 8 | 75094817 | 75108634 | Rat | 94 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] | | 1624081 | Oaz2 | ornithine decarboxylase antizyme 2 | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Anti zymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014] | 9 | 65583830 | 65597582 | Mouse | 96 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] | | 8935334 | Oaz2 | ornithine decarboxylase antizyme 2 | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cel ls. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014] | NW_004955450 | 10790629 | 10803411 | Chinchilla | 11 | symbol | gene, protein-coding, REVIEWED [RefSeq] | | 11760644 | OAZ2 | ornithine decarboxylase antizyme 2 | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cel ls. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014] | 15 | 43629712 | 43645426 | Bonobo | 18 | symbol | gene, protein-coding, REVIEWED [RefSeq] | | 12417619 | OAZ2 | ornithine decarboxylase antizyme 2 | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cel ls. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014] | 30 | 29122556 | 29126513 | Dog | 13 | symbol | gene, protein-coding, REVIEWED [RefSeq] | | 12530282 | Oaz2 | ornithine decarboxylase antizyme 2 | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cel ls. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014] | NW_004936471 | 25069035 | 25081640 | Squirrel | 19 | symbol | gene, protein-coding, REVIEWED [RefSeq] | | 14233832 | OAZ2 | ornithine decarboxylase antizyme 2 | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cel ls. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2014] | | | | Pig | 16 | symbol | gene, protein-coding, REVIEWED [RefSeq] | | 18917984 | Oaz2 | ornithine decarboxylase antizyme 2 | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cel ls. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014] | | | | Naked Mole-Rat | 16 | symbol | gene, protein-coding, REVIEWED [RefSeq] | | 155234365 | oaz2 | | | | | | Tropical Clawed Frog | | symbol | gene, null | | 18452604 | OAZ2 | ornithine decarboxylase antizyme 2 | ENCODES a protein that exhibits ornithine decarboxylase inhibitor activity (inferred); INVOLVED IN biogenic amine metabolic process (inferred); negative regulation of polyamine transmembrane transport (inferred); polyamine biosynthetic process (inferred); PARTICIPATES IN polyamine metabolic pathway; FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 18 | symbol | gene, protein-coding, MODEL [RefSeq] | | 626135762 | Oaz2 | ornithine decarboxylase antizyme 2 | ENCODES a protein that exhibits ornithine decarboxylase inhibitor activity (ortholog); INVOLVED IN negative regulation of polyamine transmembrane transport (ortholog); positive regulation of intracellular protein transport (ortholog); positive regulation of protein catabolic process (ortholog); PART ICIPATES IN polyamine metabolic pathway | | | | Black Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] | | 155231443 | oaz2.S | | | | | | African Clawed Frog | | symbol | gene, null | | 2294619 | Oaz2-ps | ornithine decarboxylase antizyme 2, pseudogene | INTERACTS WITH titanium dioxide; trovafloxacin | 3 | 135230732 | 135232397 | Mouse | 2 | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] | | 16562321 | AC100830.1 | novel transcript, antisense OAZ2 | | | | | Human | | name | gene, lncrna | | 16563996 | AC100830.2 | novel transcript, antisense to ornithine decarboxylase antizyme 2 OAZ2 | | | | | Human | | name | gene, lncrna | | 16564163 | AC100830.3 | novel transcript, antisense to ornithine decarboxylase antizyme 2 OAZ2 | | | | | Human | | name | gene, lncrna | |
