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Gene: OAZ2 (ornithine decarboxylase antizyme 2) Homo sapiens
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Symbol: OAZ2
Name: ornithine decarboxylase antizyme 2
Description: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AZ2; ODC-Az 2
Orthologs:
Mus musculus (house mouse) : Oaz2 (ornithine decarboxylase antizyme 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Oaz2 (ornithine decarboxylase antizyme 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Oaz2 (ornithine decarboxylase antizyme 2)
Pan paniscus (bonobo/pygmy chimpanzee) : OAZ2 (ornithine decarboxylase antizyme 2)
Canis lupus familiaris (dog) : OAZ2 (ornithine decarboxylase antizyme 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Oaz2 (ornithine decarboxylase antizyme 2)
Sus scrofa (pig) : OAZ2 (ornithine decarboxylase antizyme 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381564,687,574 - 64,703,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371564,979,773 - 64,995,462 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361562,766,829 - 62,782,507 (-)NCBINCBI36hg18NCBI36
Build 341562,766,828 - 62,782,507NCBI
Celera1541,857,387 - 41,873,073 (-)NCBI
Cytogenetic Map15q22.31NCBI
HuRef1541,805,393 - 41,821,079 (-)NCBIHuRef
CHM1_11565,099,012 - 65,114,718 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

Nucleotide Sequences
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Additional Information

External Database Links
 
More on OAZ2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344023
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.