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Gene: OAZ2 (ornithine decarboxylase antizyme 2) Homo sapiens
Symbol: OAZ2
Name: ornithine decarboxylase antizyme 2
Description: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AZ2; ODC-Az 2
Mus musculus (house mouse) : Oaz2 (ornithine decarboxylase antizyme 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Oaz2 (ornithine decarboxylase antizyme 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Oaz2 (ornithine decarboxylase antizyme 2)
Pan paniscus (bonobo/pygmy chimpanzee) : OAZ2 (ornithine decarboxylase antizyme 2)
Canis lupus familiaris (dog) : OAZ2 (ornithine decarboxylase antizyme 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Oaz2 (ornithine decarboxylase antizyme 2)
Sus scrofa (pig) : OAZ2 (ornithine decarboxylase antizyme 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381564,687,574 - 64,703,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371564,979,773 - 64,995,462 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361562,766,829 - 62,782,507 (-)NCBINCBI36hg18NCBI36
Build 341562,766,828 - 62,782,507NCBI
Celera1541,857,387 - 41,873,073 (-)NCBI
Cytogenetic Map15q22.31NCBI
HuRef1541,805,393 - 41,821,079 (-)NCBIHuRef
CHM1_11565,099,012 - 65,114,718 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on OAZ2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344023
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.