OAZ2 (ornithine decarboxylase antizyme 2) - Rat Genome Database

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Gene: OAZ2 (ornithine decarboxylase antizyme 2) Sus scrofa
Analyze
Symbol: OAZ2
Name: ornithine decarboxylase antizyme 2
RGD ID: 14233832
Description: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2014]
Type: protein-coding
RefSeq Status: REVIEWED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1107,325,190 - 107,341,469 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11107,325,225 - 107,338,475 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21118,156,768 - 118,169,231 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:17332016  


Genomics

Comparative Map Data
OAZ2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1107,325,190 - 107,341,469 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11107,325,225 - 107,338,475 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21118,156,768 - 118,169,231 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OAZ2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1564,687,573 - 64,703,281 (-)EnsemblGRCh38hg38GRCh38
GRCh381564,687,574 - 64,703,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371564,979,773 - 64,995,480 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361562,766,829 - 62,782,507 (-)NCBINCBI36hg18NCBI36
Build 341562,766,828 - 62,782,507NCBI
Celera1541,857,387 - 41,873,073 (-)NCBI
Cytogenetic Map15q22.31NCBI
HuRef1541,805,393 - 41,821,079 (-)NCBIHuRef
CHM1_11565,099,012 - 65,114,700 (-)NCBICHM1_1
Oaz2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39965,583,830 - 65,597,582 (+)NCBIGRCm39mm39
GRCm39 Ensembl965,575,283 - 65,597,582 (+)Ensembl
GRCm38965,676,548 - 65,690,300 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl965,668,001 - 65,690,300 (+)EnsemblGRCm38mm10GRCm38
MGSCv37965,524,355 - 65,538,107 (+)NCBIGRCm37mm9NCBIm37
MGSCv36965,474,596 - 65,488,303 (+)NCBImm8
Celera962,907,100 - 62,920,974 (+)NCBICelera
Cytogenetic Map9CNCBI
Oaz2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2866,199,694 - 66,213,513 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl866,199,706 - 66,231,453 (+)Ensembl
Rnor_6.0871,216,011 - 71,229,788 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl871,216,178 - 71,228,713 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0870,899,391 - 70,913,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4869,935,001 - 69,948,824 (+)NCBIRGSC3.4rn4RGSC3.4
Celera865,590,922 - 65,604,738 (+)NCBICelera
Cytogenetic Map8q24NCBI
Oaz2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545010,790,829 - 10,802,276 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545010,790,629 - 10,803,411 (+)NCBIChiLan1.0ChiLan1.0
OAZ2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11561,918,402 - 61,934,042 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1561,919,532 - 61,933,821 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01543,629,712 - 43,645,426 (-)NCBIMhudiblu_PPA_v0panPan3
OAZ2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13029,122,556 - 29,126,513 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3029,122,556 - 29,126,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3029,041,834 - 29,058,849 (-)NCBI
ROS_Cfam_1.03029,299,981 - 29,317,009 (-)NCBI
UMICH_Zoey_3.13029,234,170 - 29,251,175 (-)NCBI
UNSW_CanFamBas_1.03029,296,091 - 29,313,098 (-)NCBI
UU_Cfam_GSD_1.03029,536,057 - 29,553,079 (-)NCBI
Oaz2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640107,220,972 - 107,233,577 (-)NCBI
SpeTri2.0NW_00493647125,069,035 - 25,081,640 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OAZ2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12618,881,776 - 18,897,043 (+)NCBI
ChlSab1.1 Ensembl2618,881,831 - 18,895,915 (+)Ensembl
Vero_WHO_p1.0NW_023666048122,525,688 - 122,552,998 (-)NCBI
Oaz2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247817,891,104 - 7,904,720 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 4 3 5 2 23 2 3 3
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005026   ⟹   ENSSSCP00000004906
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1107,325,229 - 107,339,334 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000040536   ⟹   ENSSSCP00000036708
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1107,325,229 - 107,341,469 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000064794   ⟹   ENSSSCP00000055965
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1107,325,190 - 107,338,122 (+)Ensembl
RefSeq Acc Id: NM_001122995   ⟹   NP_001116467
RefSeq Status: REVIEWED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11107,325,225 - 107,338,475 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001301326   ⟹   NP_001288255
RefSeq Status: REVIEWED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11107,325,225 - 107,338,475 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001116467 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288255 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACB41769 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001116467   ⟸   NM_001122995
- Peptide Label: isoform 1
- UniProtKB: B2CR16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288255   ⟸   NM_001301326
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: ENSSSCP00000036708   ⟸   ENSSSCT00000040536
RefSeq Acc Id: ENSSSCP00000055965   ⟸   ENSSSCT00000064794
RefSeq Acc Id: ENSSSCP00000004906   ⟸   ENSSSCT00000005026


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004550 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000004906 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000036708 UniProtKB/TrEMBL
  ENSSSCP00000055965 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005026 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000040536 UniProtKB/TrEMBL
  ENSSSCT00000064794 UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.60 UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  ODC-AZ_2 UniProtKB/TrEMBL
  ODC_AZ UniProtKB/TrEMBL
  ODC_AZ_sf UniProtKB/TrEMBL
KEGG Report ssc:100144447 UniProtKB/TrEMBL
NCBI Gene OAZ2 ENTREZGENE
PANTHER PTHR10279 UniProtKB/TrEMBL
  PTHR10279:SF6 UniProtKB/TrEMBL
Pfam ODC_AZ UniProtKB/TrEMBL
PROSITE ODC_AZ UniProtKB/TrEMBL
Superfamily-SCOP SSF55729 UniProtKB/TrEMBL
UniProt A0A286ZYW8_PIG UniProtKB/TrEMBL
  A0A287BH98_PIG UniProtKB/TrEMBL
  B2CR16 ENTREZGENE, UniProtKB/TrEMBL
  F1S0B0_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91009 ENTREZGENE