| 621442 | Nrp2 | neuropilin 2 | ENCODES a protein that exhibits identical protein binding (ortholog); semaphorin receptor activity (ortholog); INVOLVED IN axon guidance; axon extension involved in axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); PARTICIPATES IN vascular endothelial growth facto r signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); glutamatergic synapse (ortholog); postsynaptic membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 71616602 | 71731869 | Rat | 235 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732191 | NRP2 | neuropilin 2 | This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain , secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021] | 2 | 205682501 | 205798131 | Human | 243 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551257 | Nrp2 | neuropilin 2 | Enables semaphorin receptor activity. Involved in several processes, including nervous system development; outflow tract septum morphogenesis; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitor y factor; and trunk neural crest cell migration. Located in axon. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and sensory organ. Used to study autism spectrum disorder. Orthologous to human NRP2 (neuropilin 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 62742476 | 62857851 | Mouse | 285 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8734411 | Nrp2 | neuropilin 2 | ENCODES a protein that exhibits identical protein binding (ortholog); semaphorin receptor activity (ortholog); INVOLVED IN axon extension involved in axon guidance (ortholog); axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); PARTICIPATES IN vascular endothelial g rowth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); glutamatergic synapse (ortholog); postsynaptic membrane (ortholog) | NW_004955457 | 9197621 | 9316789 | Chinchilla | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11880539 | NRP2 | neuropilin 2 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); heart development (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN axon (inferred); glutamatergic synapse (inferred); membrane (inferred) | 2B | 92911721 | 93027032 | Bonobo | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12263643 | NRP2 | neuropilin 2 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); heart development (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN axon (inferred); glutamatergic synapse (inferred); membrane (inferred) | 37 | 14293545 | 14408984 | Dog | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12644993 | Nrp2 | neuropilin 2 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); heart development (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN axon (inferred); glutamatergic synapse (inferred); membrane (inferred) | NW_004936631 | 2106378 | 2222082 | Squirrel | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18912487 | Nrp2 | neuropilin 2 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); heart development (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN axon (inferred); glutamatergic synapse (inferred); membrane (inferred) | | | | Naked Mole-Rat | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14049797 | NRP2 | neuropilin 2 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); heart development (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN axon (inferred); glutamatergic synapse (inferred); membrane (inferred); INTERACTS WITH deoxynivalenol; graphene oxide | | | | Pig | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18497066 | NRP2 | neuropilin 2 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); heart development (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN axon (inferred); glutamatergic synapse (inferred); membrane (inferred) | | | | Green Monkey | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251277 | nrp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625909670 | Nrp2 | neuropilin 2 | ENCODES a protein that exhibits identical protein binding (ortholog); semaphorin receptor activity (ortholog); INVOLVED IN axon extension involved in axon guidance (ortholog); axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); PARTICIPATES IN vascular endothelial g rowth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); glutamatergic synapse (ortholog); postsynaptic membrane (ortholog) | | | | Black Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237084 | nrp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155233130 | nrp2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 329950493 | NRP2-AS1 | NRP2 antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 16553127 | NRP2-AS1 | NRP2 antisense RNA 1 | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, lncrna |
| 732316 | NELL2 | neural EGFL like 2 | The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one iso form appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009] | 12 | 44508275 | 44921848 | Human | 141 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |