| 621341 | Nrg1 | neuregulin 1 | ENCODES a protein that exhibits receptor tyrosine kinase binding; chemorepellent activity (ortholog); ErbB-2 class receptor binding (ortholog); INVOLVED IN cardiac muscle cell apoptotic process; cellular response to acetylcholine; cellular response to brain-derived neurotrophic factor stimulus; PART ICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH abnormal habituation; abnormal spatial reference memory; abnormal spatial working memory; ASSOCIATED WITH Alzheimer's disease; amblyopia; bipolar disorder; FOUND IN dendrite; extracellular space; membrane; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate | 16 | 65954084 | 67007484 | Rat | 599 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731515 | NRG1 | neuregulin 1 | The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016] | 8 | 31639245 | 32774046 | Human | 578 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 735609 | Nrg1 | neuregulin 1 | Enables ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including ERBB signaling pathway; nervous system development; and postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including nervous system development; p ositive regulation of intracellular signal transduction; and regulation of macromolecule metabolic process. Located in several cellular components, including axon; neuromuscular junction; and plasma membrane. Is active in several cellular components, including GABA-ergic synapse; mossy fiber rosette; and synaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including cannabis dependence; cerebrovascular disease (multiple); neurodegenerative disease (multiple); psychotic disorder (multiple); and substance abuse (multiple). Orthologous to human NRG1 (neuregulin 1). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 32299493 | 33381858 | Mouse | 714 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8722430 | Nrg1 | neuregulin 1 | ENCODES a protein that exhibits chemorepellent activity (ortholog); ErbB-2 class receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); cardiac conduction system development (ortholog); cardiac muscle cell apoptotic proc ess (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amblyopia (ortholog); FOUND IN apical part of cell; basal part of cell; cell projection | NW_004955463 | 8009436 | 9037116 | Chinchilla | 244 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11950021 | NRG1 | neuregulin 1 | ENCODES a protein that exhibits ErbB-2 class receptor binding (ortholog); nickel cation binding (ortholog); receptor tyrosine kinase binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); cardiac conduction system development (ortholog); cardiac muscle cell apoptotic pro cess (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amblyopia (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axon (ortholog) | 8 | 30954852 | 32084411 | Bonobo | 243 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12208208 | NRG1 | neuregulin 1 | ENCODES a protein that exhibits ErbB-2 class receptor binding (ortholog); nickel cation binding (ortholog); receptor tyrosine kinase binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); cardiac conduction system development (ortholog); cardiac muscle cell apoptotic pro cess (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amblyopia (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axon (ortholog) | 16 | 31697958 | 32771888 | Dog | 245 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12465648 | Nrg1 | neuregulin 1 | ENCODES a protein that exhibits ErbB-2 class receptor binding (ortholog); nickel cation binding (ortholog); receptor tyrosine kinase binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); cardiac conduction system development (ortholog); cardiac muscle cell apoptotic pro cess (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amblyopia (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axon (ortholog) | NW_004936766 | 1104841 | 1306368 | Squirrel | 243 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14161199 | NRG1 | neuregulin 1 | ENCODES a protein that exhibits ErbB-2 class receptor binding (ortholog); nickel cation binding (ortholog); receptor tyrosine kinase binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); cardiac conduction system development (ortholog); cardiac muscle cell apoptotic pro cess (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amblyopia (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axon (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 246 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907556 | Nrg1 | neuregulin 1 | ENCODES a protein that exhibits ErbB-2 class receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); integrin binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); cardiac conduction system development (ortholog); cardiac muscle cell apoptotic process (or tholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amblyopia (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axon (ortholog) | | | | Naked Mole-Rat | 256 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625933356 | Nrg1 | neuregulin 1 | ENCODES a protein that exhibits chemorepellent activity (ortholog); ErbB-2 class receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); cardiac conduction system development (ortholog); cardiac muscle cell apoptotic proc ess (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amblyopia (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axon (ortholog) | | | | Black Rat | 241 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14381129 | NRG1 | | | | | | Yeast | | symbol | gene, null |
| 18614819 | NRG1 | neuregulin 1 | ENCODES a protein that exhibits ErbB-2 class receptor binding (ortholog); nickel cation binding (ortholog); receptor tyrosine kinase binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); cardiac conduction system development (ortholog); cardiac muscle cell apoptotic pro cess (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amblyopia (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axon (ortholog) | | | | Green Monkey | 242 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254171 | nrg1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935143 | nrg1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247004 | nrg1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933481 | nrg1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934572 | nrg1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935988 | nrg1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 5684144 | NRG1-IT1 | NRG1 intronic transcript 1 | INTERACTS WITH benzo[e]pyrene; herbicide; mesotrione | 8 | 32025736 | 32139477 | Human | 4 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 6481117 | NRG1-IT3 | NRG1 intronic transcript 3 | | 8 | 32440746 | 32442725 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 2290090 | Nrg1Tn(sb-T2/Bart3)2.183Mcwi | neuregulin 1; transposon insertion 2.183, Medical College of Wisconsin | ASSOCIATED WITH abnormal habituation; decreased locomotor activity; decreased prepulse inhibition; ASSOCIATED WITH stress-related disorder | | | | Rat | 8 | symbol , description , old_gene_symbol | gene, allele |
| 16571759 | AC068931.1 | novel transcript, antisense to NRG1 | | | | | Human | | name | gene, lncrna |