Nrg1 (neuregulin 1) - Rat Genome Database

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Gene: Nrg1 (neuregulin 1) Ictidomys tridecemlineatus
Analyze
Symbol: Nrg1
Name: neuregulin 1
RGD ID: 12465648
Description: ENCODES a protein that exhibits chemorepellent activity (ortholog); ErbB-2 class receptor binding (ortholog); receptor tyrosine kinase binding (ortholog); INVOLVED IN activation of transmembrane receptor protein tyrosine kinase activity (ortholog); axon ensheathment (ortholog); brain development (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amphetamine abuse (ortholog); bipolar disorder (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axolemma (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuregulin 1, transcript variant X1; neuregulin 1, transcript variant X10; neuregulin 1, transcript variant X11; neuregulin 1, transcript variant X2; neuregulin 1, transcript variant X3; neuregulin 1, transcript variant X4; neuregulin 1, transcript variant X5; neuregulin 1, transcript variant X6; neuregulin 1, transcript variant X7; neuregulin 1, transcript variant X8; neuregulin 1, transcript variant X9; pro-neuregulin-1, membrane-bound isoform
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494354,835,543 - 55,046,030 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367661,104,841 - 1,306,368 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (IEA)
activation of transmembrane receptor protein tyrosine kinase activity  (ISO)
axon ensheathment  (ISO)
brain development  (ISO)
cardiac conduction system development  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle cell myoblast differentiation  (IEA)
cardiac muscle tissue development  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
chemorepulsion involved in interneuron migration from the subpallium to the cortex  (ISO)
DNA-templated transcription  (IEA)
endocardial cell differentiation  (IEA)
ERBB signaling pathway  (IEA)
ERBB2-ERBB3 signaling pathway  (IEA)
ERBB2-ERBB4 signaling pathway  (IEA)
ERBB3 signaling pathway  (IEA)
ERBB4 signaling pathway  (IEA)
ERBB4-ERBB4 signaling pathway  (IEA)
glial cell differentiation  (ISO)
glial cell fate commitment  (ISO)
heart development  (ISO)
locomotory behavior  (ISO)
MAPK cascade  (ISO)
memory  (ISO)
muscle organ development  (ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of corticosterone secretion  (ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of neuron migration  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of secretion  (IEA)
nervous system development  (IEA,ISO)
neurogenesis  (ISO)
neuron fate commitment  (ISO)
neuron migration  (ISO)
neurotransmitter receptor metabolic process  (ISO)
odontogenesis  (ISO)
oligodendrocyte differentiation  (ISO)
peripheral nervous system development  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of calcineurin-NFAT signaling cascade  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of myelination  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-tyrosine autophosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to cell surface  (ISO)
positive regulation of protein tyrosine kinase activity  (IEA)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of Schwann cell proliferation  (ISO)
positive regulation of striated muscle cell differentiation  (ISO)
postsynapse to nucleus signaling pathway  (ISO)
protein catabolic process  (ISO)
protein kinase B signaling  (ISO)
protein-containing complex disassembly  (ISO)
regulation of cell differentiation  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of presynapse assembly  (ISO)
response to progesterone  (ISO)
Schwann cell differentiation  (ISO)
sequestering of metal ion  (ISO)
signal transduction  (IEA)
startle response  (ISO)
synapse assembly  (ISO)
synaptic membrane adhesion  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (ISO)
ventricular cardiac muscle cell differentiation  (ISO)
ventricular trabecula myocardium morphogenesis  (IEA)
wound healing  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Nrg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494354,835,543 - 55,046,030 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367661,104,841 - 1,306,368 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38831,639,245 - 32,774,046 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl831,639,222 - 32,855,666 (+)EnsemblGRCh38hg38GRCh38
GRCh37831,496,761 - 32,631,564 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36831,616,810 - 32,741,615 (+)NCBINCBI36Build 36hg18NCBI36
Build 34832,525,654 - 32,741,615NCBI
Celera830,430,833 - 31,581,276 (+)NCBICelera
Cytogenetic Map8p12NCBI
HuRef830,042,037 - 31,167,972 (+)NCBIHuRef
CHM1_1831,698,276 - 32,824,231 (+)NCBICHM1_1
T2T-CHM13v2.0831,920,455 - 33,055,399 (+)NCBIT2T-CHM13v2.0
Nrg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39832,299,493 - 33,381,858 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl832,304,579 - 33,374,825 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl832,408,601 - 32,408,786 (-)EnsemblGRCm39 Ensembl
GRCm38831,807,452 - 32,891,609 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl831,814,551 - 32,884,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv37832,928,500 - 33,028,675 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36833,280,406 - 33,475,426 (-)NCBIMGSCv36mm8
Celera833,340,249 - 33,441,164 (-)NCBICelera
Cytogenetic Map8A3NCBI
Nrg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21659,250,658 - 60,303,024 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1659,250,854 - 60,296,884 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1664,587,755 - 65,638,290 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01668,001,434 - 69,052,009 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01663,221,979 - 64,273,342 (+)NCBIRnor_WKY
Rnor_6.01662,969,573 - 64,065,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1663,837,216 - 64,057,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01662,632,432 - 63,718,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41663,937,796 - 64,126,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11663,937,870 - 64,126,262 (+)NCBI
Celera1657,283,140 - 58,311,856 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
Nrg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554638,009,530 - 9,037,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554638,009,436 - 9,037,116 (+)NCBIChiLan1.0ChiLan1.0
NRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1829,049,787 - 29,267,531 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl829,050,222 - 29,263,977 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0830,954,852 - 32,084,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11631,697,958 - 32,771,888 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1631,706,851 - 32,771,932 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1632,223,605 - 33,296,875 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01633,726,025 - 34,800,223 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1633,733,366 - 34,799,290 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11631,820,963 - 32,893,204 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01632,400,606 - 33,474,314 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01632,439,477 - 33,584,021 (-)NCBIUU_Cfam_GSD_1.0
NRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1552,630,679 - 52,839,505 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11552,625,550 - 53,688,003 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21559,915,458 - 59,983,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1829,745,984 - 30,862,140 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl830,635,803 - 30,856,487 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605211,219,877 - 12,342,139 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478011,301,182 - 12,424,066 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478011,297,306 - 11,525,236 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005340067   ⟹   XP_005340124
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 54,956,218 (-)NCBI
SpeTri2.0NW_0049367661,104,932 - 1,216,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005340068   ⟹   XP_005340125
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 54,956,219 (-)NCBI
SpeTri2.0NW_0049367661,104,932 - 1,216,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005340069   ⟹   XP_005340126
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 55,046,020 (-)NCBI
SpeTri2.0NW_0049367661,104,841 - 1,306,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005340070   ⟹   XP_005340127
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 55,046,025 (-)NCBI
SpeTri2.0NW_0049367661,104,841 - 1,306,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005340074   ⟹   XP_005340131
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,845,020 - 55,046,030 (-)NCBI
SpeTri2.0NW_0049367661,105,405 - 1,306,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005340076   ⟹   XP_005340133
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,845,125 - 54,883,031 (-)NCBI
SpeTri2.0NW_0049367661,105,585 - 1,143,696 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021719981   ⟹   XP_021575656
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 55,046,016 (-)NCBI
SpeTri2.0NW_0049367661,104,932 - 1,306,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021719982   ⟹   XP_021575657
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,845,125 - 54,956,216 (-)NCBI
SpeTri2.0NW_0049367661,105,585 - 1,216,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021719983   ⟹   XP_021575658
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,845,125 - 54,956,217 (-)NCBI
SpeTri2.0NW_0049367661,105,585 - 1,216,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021719984   ⟹   XP_021575659
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 54,883,028 (-)NCBI
SpeTri2.0NW_0049367661,104,932 - 1,143,696 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021719985   ⟹   XP_021575660
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,845,125 - 55,046,022 (-)NCBI
SpeTri2.0NW_0049367661,105,585 - 1,306,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040269051   ⟹   XP_040124985
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,847,955 - 54,956,215 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005340131   ⟸   XM_005340074
- Peptide Label: isoform X10
- UniProtKB: A0A287DFF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005340133   ⟸   XM_005340076
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_005340124   ⟸   XM_005340067
- Peptide Label: isoform X1
- UniProtKB: A0A287DFC5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005340126   ⟸   XM_005340069
- Peptide Label: isoform X3
- UniProtKB: A0A287CYR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005340127   ⟸   XM_005340070
- Peptide Label: isoform X4
- UniProtKB: A0A287CZ88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005340125   ⟸   XM_005340068
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021575656   ⟸   XM_021719981
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_021575659   ⟸   XM_021719984
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_021575660   ⟸   XM_021719985
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_021575657   ⟸   XM_021719982
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_021575658   ⟸   XM_021719983
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_040124985   ⟸   XM_040269051
- Peptide Label: isoform X9
Protein Domains
EGF-like   Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000021833 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000016153.2 UniProtKB/TrEMBL
  ENSSTOP00000026411 ENTREZGENE
  ENSSTOP00000026411.1 UniProtKB/TrEMBL
  ENSSTOP00000026593 ENTREZGENE
  ENSSTOP00000026593.1 UniProtKB/TrEMBL
  ENSSTOP00000028343.1 UniProtKB/TrEMBL
  ENSSTOP00000032242 ENTREZGENE
  ENSSTOP00000032242.1 UniProtKB/TrEMBL
  ENSSTOP00000032253 ENTREZGENE
  ENSSTOP00000032253.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000027990.2 UniProtKB/TrEMBL
  ENSSTOT00000032556.1 UniProtKB/TrEMBL
  ENSSTOT00000035894.1 UniProtKB/TrEMBL
  ENSSTOT00000039365.1 UniProtKB/TrEMBL
  ENSSTOT00000042757.1 UniProtKB/TrEMBL
  ENSSTOT00000043306.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Neuregulin UniProtKB/TrEMBL
  Neuregulin_C UniProtKB/TrEMBL
  NRG1 UniProtKB/TrEMBL
NCBI Gene Nrg1 ENTREZGENE
PANTHER PTHR11100 UniProtKB/TrEMBL
  PTHR11100:SF25 UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  Neuregulin UniProtKB/TrEMBL
PRINTS NEUREGULIN UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A287CYR4 ENTREZGENE, UniProtKB/TrEMBL
  A0A287CZ88 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D462_ICTTR UniProtKB/TrEMBL
  A0A287DFC5 ENTREZGENE, UniProtKB/TrEMBL
  A0A287DFF5 ENTREZGENE, UniProtKB/TrEMBL
  I3MVK8_ICTTR UniProtKB/TrEMBL