Nrg1 (neuregulin 1) - Rat Genome Database

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Gene: Nrg1 (neuregulin 1) Ictidomys tridecemlineatus
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Symbol: Nrg1
Name: neuregulin 1
RGD ID: 12465648
Description: ENCODES a protein that exhibits chemorepellent activity (ortholog); ErbB-2 class receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); activation of transmembrane receptor protein tyrosine kinase activity (ortholog); axon ensheathment (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amphetamine abuse (ortholog); bipolar disorder (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axolemma (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: neuregulin 1, transcript variant X1; neuregulin 1, transcript variant X10; neuregulin 1, transcript variant X11; neuregulin 1, transcript variant X2; neuregulin 1, transcript variant X3; neuregulin 1, transcript variant X4; neuregulin 1, transcript variant X5; neuregulin 1, transcript variant X6; neuregulin 1, transcript variant X7; neuregulin 1, transcript variant X8; neuregulin 1, transcript variant X9; pro-neuregulin-1, membrane-bound isoform
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494354,835,543 - 55,046,030 (-)NCBI
SpeTri2.0NW_0049367661,104,841 - 1,306,368 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
activation of transmembrane receptor protein tyrosine kinase activity  (ISO)
axon ensheathment  (ISO)
brain development  (ISO)
cardiac conduction system development  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle cell myoblast differentiation  (ISO)
cardiac muscle tissue development  (ISO)
cell migration  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cellular protein complex disassembly  (ISO)
chemorepulsion involved in interneuron migration from the subpallium to the cortex  (ISO)
endocardial cell differentiation  (ISO)
ERBB signaling pathway  (ISO)
ERBB3 signaling pathway  (ISO)
ERBB4 signaling pathway  (ISO)
glial cell differentiation  (ISO)
glial cell fate commitment  (ISO)
heart development  (ISO)
locomotory behavior  (ISO)
MAPK cascade  (ISO)
memory  (ISO)
muscle organ development  (ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of corticosterone secretion  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of neuron migration  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of secretion  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
nervous system development  (ISO)
neurogenesis  (ISO)
neuron fate commitment  (ISO)
neurotransmitter receptor metabolic process  (ISO)
odontogenesis  (ISO)
oligodendrocyte differentiation  (ISO)
peripheral nervous system development  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of calcineurin-NFAT signaling cascade  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of myelination  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-tyrosine autophosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to cell surface  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of Schwann cell proliferation  (ISO)
positive regulation of striated muscle cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
postsynapse to nucleus signaling pathway  (ISO)
regulation of cell differentiation  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
response to progesterone  (ISO)
startle response  (ISO)
synapse assembly  (ISO)
synaptic membrane adhesion  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (ISO)
ventricular cardiac muscle cell differentiation  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)
wound healing  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Nrg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494354,835,543 - 55,046,030 (-)NCBI
SpeTri2.0NW_0049367661,104,841 - 1,306,368 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl831,639,222 - 32,855,666 (+)EnsemblGRCh38hg38GRCh38
GRCh38831,639,245 - 32,774,046 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37831,496,761 - 32,631,564 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36831,616,810 - 32,741,615 (+)NCBINCBI36hg18NCBI36
Build 34832,525,654 - 32,741,615NCBI
Celera830,430,833 - 31,581,276 (+)NCBI
Cytogenetic Map8p12NCBI
HuRef830,042,037 - 31,167,972 (+)NCBIHuRef
CHM1_1831,698,276 - 32,824,231 (+)NCBICHM1_1
Nrg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39832,299,493 - 33,381,858 (-)NCBIGRCm39mm39
GRCm39 Ensembl832,304,579 - 33,374,825 (-)Ensembl
GRCm39 Ensembl832,408,601 - 32,408,786 (-)Ensembl
GRCm38831,807,452 - 32,891,609 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl831,814,551 - 32,884,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv37832,928,500 - 33,028,675 (-)NCBIGRCm37mm9NCBIm37
MGSCv36833,280,406 - 33,475,426 (-)NCBImm8
Celera833,340,249 - 33,441,164 (-)NCBICelera
Cytogenetic Map8A3NCBI
Nrg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21659,250,658 - 60,303,024 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1659,250,854 - 60,296,884 (+)Ensembl
Rnor_6.01662,969,573 - 64,065,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1663,837,216 - 64,057,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01662,632,432 - 63,718,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41663,937,796 - 64,126,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11663,937,870 - 64,126,262 (+)NCBI
Celera1657,283,140 - 58,311,856 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
Nrg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554638,009,530 - 9,037,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554638,009,436 - 9,037,116 (+)NCBIChiLan1.0ChiLan1.0
NRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1829,049,787 - 29,267,531 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl829,050,222 - 29,263,977 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0830,954,852 - 32,084,411 (+)NCBIMhudiblu_PPA_v0panPan3
NRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11631,697,958 - 32,771,888 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1631,706,851 - 32,771,932 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1632,223,605 - 33,296,875 (-)NCBI
ROS_Cfam_1.01633,726,025 - 34,800,223 (-)NCBI
UMICH_Zoey_3.11631,820,963 - 32,893,204 (-)NCBI
UNSW_CanFamBas_1.01632,400,606 - 33,474,314 (-)NCBI
UU_Cfam_GSD_1.01632,439,477 - 33,584,021 (-)NCBI
NRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1552,627,334 - 53,688,332 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11552,625,550 - 53,688,003 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21559,915,458 - 59,983,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1829,745,984 - 30,862,140 (+)NCBI
ChlSab1.1 Ensembl830,635,803 - 30,856,487 (+)Ensembl
Vero_WHO_p1.0NW_02366605211,219,877 - 12,342,139 (-)NCBI
Nrg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478011,297,306 - 11,525,236 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005340067   ⟹   XP_005340124
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 54,956,218 (-)NCBI
SpeTri2.0NW_0049367661,104,932 - 1,216,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005340068   ⟹   XP_005340125
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 54,956,219 (-)NCBI
SpeTri2.0NW_0049367661,104,932 - 1,216,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005340069   ⟹   XP_005340126
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 55,046,020 (-)NCBI
SpeTri2.0NW_0049367661,104,841 - 1,306,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005340070   ⟹   XP_005340127
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 55,046,025 (-)NCBI
SpeTri2.0NW_0049367661,104,841 - 1,306,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005340074   ⟹   XP_005340131
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,845,020 - 55,046,030 (-)NCBI
SpeTri2.0NW_0049367661,105,405 - 1,306,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005340076   ⟹   XP_005340133
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,845,125 - 54,883,031 (-)NCBI
SpeTri2.0NW_0049367661,105,585 - 1,143,696 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021719981   ⟹   XP_021575656
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 55,046,016 (-)NCBI
SpeTri2.0NW_0049367661,104,932 - 1,306,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021719982   ⟹   XP_021575657
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,845,125 - 54,956,216 (-)NCBI
SpeTri2.0NW_0049367661,105,585 - 1,216,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021719983   ⟹   XP_021575658
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,845,125 - 54,956,217 (-)NCBI
SpeTri2.0NW_0049367661,105,585 - 1,216,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021719984   ⟹   XP_021575659
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,835,543 - 54,883,028 (-)NCBI
SpeTri2.0NW_0049367661,104,932 - 1,143,696 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021719985   ⟹   XP_021575660
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,845,125 - 55,046,022 (-)NCBI
SpeTri2.0NW_0049367661,105,585 - 1,306,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040269051   ⟹   XP_040124985
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494354,847,955 - 54,956,215 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005340131   ⟸   XM_005340074
- Peptide Label: isoform X10
- UniProtKB: A0A287DFF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005340133   ⟸   XM_005340076
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_005340124   ⟸   XM_005340067
- Peptide Label: isoform X1
- UniProtKB: A0A287DFC5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005340126   ⟸   XM_005340069
- Peptide Label: isoform X3
- UniProtKB: A0A287CYR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005340127   ⟸   XM_005340070
- Peptide Label: isoform X4
- UniProtKB: A0A287CZ88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005340125   ⟸   XM_005340068
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021575656   ⟸   XM_021719981
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_021575659   ⟸   XM_021719984
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_021575660   ⟸   XM_021719985
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_021575657   ⟸   XM_021719982
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_021575658   ⟸   XM_021719983
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_040124985   ⟸   XM_040269051
- Peptide Label: isoform X9


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000021833 ENTREZGENE
Ensembl Protein ENSSTOP00000026411 ENTREZGENE
  ENSSTOP00000026593 ENTREZGENE
  ENSSTOP00000032242 ENTREZGENE
  ENSSTOP00000032253 ENTREZGENE
NCBI Gene Nrg1 ENTREZGENE
UniProt A0A287CYR4 ENTREZGENE
  A0A287CZ88 ENTREZGENE
  A0A287DFC5 ENTREZGENE
  A0A287DFF5 ENTREZGENE