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Gene: Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi} (neuregulin 1; transposon insertion 2.183, Medical College of Wisconsin) Rattus norvegicus

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Symbol:

Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}

Name:

neuregulin 1; transposon insertion 2.183, Medical College of Wisconsin

RGD ID:

2290090

Description:

this mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1^st intron of the Nrg1 gene
ASSOCIATED WITH abnormal habituation; decreased locomotor activity; decreased prepulse inhibition; ASSOCIATED WITH stress-related disorder

Type:

allele of Nrg1

Previously known as:

Nrg1^[Tn(sb-T2/Bart3)2.183Mcwi]; Nrg1Tn(sb-T2/Bart3)2.183Mcwi

Is Marker For:

Strains: F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Cytogenetic Map	16		RGD

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

stress-related disorder (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal habituation (IMP)

decreased locomotor activity (IMP)

decreased prepulse inhibition (IMP)

impaired cued conditioning behavior (IMP)

increased body weight (IMP)

increased circulating corticosterone level (IMP)

increased startle reflex (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system.	Lu B, etal., Mamm Genome. 2007 May;18(5):338-46. Epub 2007 Jun 8.
2.	PhysGen Strains	PhysGen strains
3.	Sex-specific neuroendocrine and behavioral phenotypes in hypomorphic Type II Neuregulin 1 rats.	Taylor SB, etal., Behav Brain Res. 2011 Oct 31;224(2):223-32. doi: 10.1016/j.bbr.2011.05.008. Epub 2011 May 19.
4.	The interaction of disrupted type II neuregulin 1 and chronic adolescent stress on adult anxiety- and fear-related behaviors.	Taylor SB, etal., Neuroscience. 2013 Sep 26;249:31-42. doi: 10.1016/j.neuroscience.2012.09.045. Epub 2012 Sep 25.
5.	Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli.	Taylor SB, etal., Physiol Behav. 2011 Aug 3;104(2):205-14. doi: 10.1016/j.physbeh.2010.11.015. Epub 2010 Nov 16.

Genomics

Related Rat Strains

The following Strains have been annotated to Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}

F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031588	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype