| 1303282 | Notch4 | notch receptor 4 | ENCODES a protein that exhibits Notch binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN endothelial cell differentiation; endothelial cell morphogenesis; luteolysis; PARTICIPATES IN Notch signaling pathway; altered Notch signaling pathway; Notch signaling pathway; ASSOCI ATED WITH AIDS-Associated Nephropathy; Hypertrophic Cicatrix; alopecia areata (ortholog); FOUND IN cell surface (ortholog); cytoplasmic vesicle (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylfuran | 20 | 4164969 | 4189072 | Rat | 187 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1354309 | NOTCH4 | notch receptor 4 | This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple dif ferent domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] | 6 | 32194843 | 32224067 | Human | 213 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553588 | Notch4 | notch 4 | Enables Notch binding activity. Involved in branching involved in blood vessel morphogenesis and negative regulation of endothelial cell differentiation. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; positive regulation of angiogenesis; and p ositive regulation of aorta morphogenesis. Located in cytoplasmic vesicle and endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; early conceptus; genitourinary system; and gut. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (notch receptor 4). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 34783257 | 34807517 | Mouse | 220 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8969956 | Notch4 | notch receptor 4 | ENCODES a protein that exhibits Notch binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); endothelial cell differentiation (ortholog); endothelial cell morphogenesis (ortholog); PARTICIPATES IN Notch signaling pa thway; ASSOCIATED WITH AIDS-Associated Nephropathy (ortholog); alopecia areata (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cell surface (ortholog); cytoplasmic vesicle (ortholog); endoplasmic reticulum (ortholog) | NW_004955437 | 658076 | 679338 | Chinchilla | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11681587 | NOTCH4 | notch receptor 4 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); endothelial cell differentiation (ortholog); endothelial cell morphogenesis (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH AIDS-Associated Nephropa thy (ortholog); alopecia areata (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasmic vesicle (ortholog); endoplasmic reticulum (ortholog) | 6 | 31842233 | 31871412 | Bonobo | 91 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12229674 | NOTCH4 | notch receptor 4 | ENCODES a protein that exhibits Notch binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); endothelial cell differentiation (ortholog); endothelial cell morphogenesis (ortholog); PARTICIPATES IN Notch signaling pa thway; ASSOCIATED WITH AIDS-Associated Nephropathy (ortholog); alopecia areata (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cell surface (ortholog); cytoplasmic vesicle (ortholog) | 12 | 1585249 | 1608721 | Dog | 84 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12499199 | Notch4 | notch receptor 4 | ENCODES a protein that exhibits Notch binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); endothelial cell differentiation (ortholog); endothelial cell morphogenesis (ortholog); PARTICIPATES IN Notch signaling pa thway; ASSOCIATED WITH AIDS-Associated Nephropathy (ortholog); alopecia areata (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cell surface (ortholog); cytoplasmic vesicle (ortholog) | NW_004936727 | 1386842 | 1409823 | Squirrel | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285256708 | notch4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625961502 | Notch4 | notch receptor 4 | ENCODES a protein that exhibits Notch binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); endothelial cell differentiation (ortholog); endothelial cell morphogenesis (ortholog); PARTICIPATES IN Notch signaling pa thway; ASSOCIATED WITH AIDS-Associated Nephropathy (ortholog); alopecia areata (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cell surface (ortholog); cytoplasmic vesicle (ortholog); endoplasmic reticulum (ortholog) | | | | Black Rat | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14079373 | NOTCH4 | notch receptor 4 | ENCODES a protein that exhibits calcium ion binding (inferred); metal ion binding (inferred); signaling receptor activity (inferred); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); endothelial cell differentiation (ortholog); endothelial cell morphogenesis (ortholog); PARTI CIPATES IN Notch signaling pathway; ASSOCIATED WITH AIDS-Associated Nephropathy (ortholog); alopecia areata (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasmic vesicle (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 86 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18707726 | NOTCH4 | notch receptor 4 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); endothelial cell differentiation (ortholog); endothelial cell morphogenesis (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH AIDS-Associated Nephropa thy (ortholog); alopecia areata (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasmic vesicle (ortholog); endoplasmic reticulum (ortholog) | | | | Green Monkey | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904205 | Notch4 | notch receptor 4 | ENCODES a protein that exhibits Notch binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); endothelial cell differentiation (ortholog); endothelial cell morphogenesis (ortholog); PARTICIPATES IN Notch signaling pa thway; ASSOCIATED WITH AIDS-Associated Nephropathy (ortholog); alopecia areata (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasmic vesicle (ortholog) | | | | Naked Mole-Rat | 91 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285256248 | notch4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 287114664 | notch4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1332497 | Egfl7 | EGF-like domain 7 | Enables Notch binding activity. Involved in vasculogenesis. Acts upstream of or within negative regulation of smooth muscle cell migration. Located in extracellular space. Is expressed in several structures, including cardiovascular system; early conceptus; embryo mesenchyme; genitourinary system; a nd retina. Orthologous to human EGFL7 (EGF like domain multiple 7). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 26471095 | 26482694 | Mouse | 130 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1602888 | EGFL7 | EGF like domain multiple 7 | This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcri pt variants. [provided by RefSeq, Feb 2012] | 9 | 136658856 | 136672678 | Human | 117 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 596934297 | notch4p.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933376 | notch4p.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933909 | notch4p.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934432 | notch4p.L | | | | | | African Clawed Frog | | symbol | gene, null |