| 619877 | Nme2 | NME/NM23 nucleoside diphosphate kinase 2 | ENCODES a protein that exhibits enzyme binding; fatty acid binding; heterocyclic compound binding; INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to fatty acid; cellular response to glucose stimulus; PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimidine biosynthetic pathway; Glut1 deficiency syndrome pathway; ASSOCIATED WITH decreased metastatic potential; ASSOCIATED WITH Neoplasm Metastasis; arteriosclerosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN intermediate filament; mitochondrial membrane; perinuclear region of cytoplasm; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 10 | 79394999 | 79400418 | Rat | 259 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1346564 | NME2 | NME/NM23 nucleoside diphosphate kinase 2 | Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturall y-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010] | 17 | 51165536 | 51171744 | Human | 254 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1552274 | Nme2 | NME/NM23 nucleoside diphosphate kinase 2 | Predicted to enable several functions, including anion binding activity; kinase activity; and transcription coactivator activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; negative regulation of myeloid leukocyte differentiation; and ribonucleoside triphosphate biosynthetic process. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in teratoma. Orthologous to several human genes including NME2 (NME/NM23 nucleoside diphosphate kinase 2). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 93840640 | 93847082 | Mouse | 285 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 11745893 | NME2 | NME/NM23 nucleoside diphosphate kinase 2 | ENCODES a protein that exhibits coenzyme A binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to fatty acid (ortholog); cellular respo nse to glucose stimulus (ortholog); PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimidine biosynthetic pathway; Glut1 deficiency syndrome pathway; ASSOCIATED WITH arteriosclerosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell periphery (ortholog); cytoplasm (ortholog); cytosol (ortholog) | 17 | 45255982 | 45261541 | Bonobo | 95 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12238112 | NME2 | non-metastatic cells 2, protein (NM23B) expressed in | ENCODES a protein that exhibits coenzyme A binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to fatty acid (ortholog); cellular respo nse to glucose stimulus (ortholog); PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimidine biosynthetic pathway; Glut1 deficiency syndrome pathway; ASSOCIATED WITH arteriosclerosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell periphery (ortholog); cytoplasm (ortholog); cytosol (ortholog) | 9 | 27002114 | 27005740 | Dog | 107 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12452597 | Nme2 | NME/NM23 nucleoside diphosphate kinase 2 | ENCODES a protein that exhibits enzyme binding (ortholog); fatty acid binding (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to fatty acid (ortholog); cellular response to gluco se stimulus (ortholog); PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimidine biosynthetic pathway; Glut1 deficiency syndrome pathway; ASSOCIATED WITH arteriosclerosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN focal adhesion (ortholog); intermediate filament (ortholog); mitochondrial membrane (ortholog) | NW_004936490 | 10634788 | 10640182 | Squirrel | 99 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14067043 | NME2 | NME/NM23 nucleoside diphosphate kinase 2 | ENCODES a protein that exhibits coenzyme A binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to fatty acid (ortholog); cellular respo nse to glucose stimulus (ortholog); PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimidine biosynthetic pathway; Glut1 deficiency syndrome pathway; ASSOCIATED WITH arteriosclerosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell periphery (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Pig | 107 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 155258044 | nme2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625872747 | Nme2 | NME/NM23 nucleoside diphosphate kinase 2 | ENCODES a protein that exhibits coenzyme A binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to fatty acid (ortholog); cellular respo nse to glucose stimulus (ortholog); PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimidine biosynthetic pathway; Glut1 deficiency syndrome pathway; ASSOCIATED WITH arteriosclerosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell periphery (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 87 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257114 | nme2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258043 | nme2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1594734 | Nme2-ps1 | NME/NM23 nucleoside diphosphate kinase 2, pseudogene 1 | INTERACTS WITH ammonium chloride | 20 | 11178950 | 11179551 | Rat | 1 | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 7654995 | Nme2-ps2 | NME/NM23 nucleoside diphosphate kinase 2, pseudogene 2 | | 3 | 41529211 | 41532588 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41206447 | Nme2-ps3 | NME/NM23 nucleoside diphosphate kinase 2, pseudogene 3 | | 2 | 230369846 | 230370829 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41258656 | Nme2-ps4 | NME/NM23 nucleoside diphosphate kinase 2, pseudogene 4 | | 4 | 9231041 | 9231491 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1589698 | Nme2-ps6 | NME/NM23 nucleoside diphosphate kinase 2, pseudogene 6 | | 3 | 41271935 | 41273626 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1595422 | Nme2-ps7 | NME/NM23 nucleoside diphosphate kinase 2, pseudogene 7 | | 2 | 35204942 | 35207505 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1565403 | Nme2-ps8 | NME/NM23 nucleoside diphosphate kinase 2, pseudogene 8 | INTERACTS WITH methoxychlor | 8 | 108002561 | 108003149 | Rat | 1 | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1642401 | NME1-NME2 | NME1-NME2 readthrough | This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative spli cing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010] | 17 | 51153559 | 51171744 | Human | 35 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 597976611 | Nme1-nme2 | Nme1-Nme2 readthrough | | | | | Mouse | | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8830953 | LOC102025422 | nucleoside diphosphate kinase B | | NW_004955451 | 10731941 | 10736353 | Chinchilla | | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18457099 | LOC103242911 | nucleoside diphosphate kinase B | ENCODES a protein that exhibits enzyme binding (ortholog); fatty acid binding (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to fatty acid (ortholog); cellular response to gluco se stimulus (ortholog); PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimidine biosynthetic pathway; Glut1 deficiency syndrome pathway; ASSOCIATED WITH arteriosclerosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN focal adhesion (ortholog); intermediate filament (ortholog); mitochondrial membrane (ortholog) | | | | Green Monkey | 99 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18906930 | LOC106007568 | nucleoside diphosphate kinase B | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); metal ion binding (inferred); INVOLVED IN CTP biosynthetic process (inferred); GTP biosynthetic process (inferred); nucleoside triphosphate biosynthetic process (inferred) | | | | Naked Mole-Rat | 14 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1354297 | NME2P1 | NME2 pseudogene 1 | Predicted to enable ATP binding activity; metal ion binding activity; and nucleoside diphosphate kinase activity. Predicted to be involved in regulation of apoptotic process. Located in extracellular exosome and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 120282218 | 120282856 | Human | 6 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 18183053 | NME2P2 | NME2 pseudogene 2 | | 2 | 47705468 | 47706036 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 18183050 | NME2P3 | NME2 pseudogene 3 | | 9 | 98890407 | 98892076 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16561022 | AC092470.1 | Nucleoside diphosphate kinase B (NME2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16555775 | AL135924.1 | non-metastatic cells 2, protein (NM23B) expressed in (NME2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16554394 | AL136084.1 | non-metastatic cells 2, protein (NM23B) expressed in (NME2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 8811702 | LOC102025966 | nucleoside diphosphate kinase A | | NW_004955451 | 10737976 | 10744261 | Chinchilla | | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 735393 | NME1 | NME/NM23 nucleoside diphosphate kinase 1 | This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene ha ve been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008] | 17 | 51153559 | 51162168 | Human | 356 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11746422 | NME1 | NME/NM23 nucleoside diphosphate kinase 1 | ENCODES a protein that exhibits 3'-5'-DNA exonuclease activity (ortholog); acetyl-CoA binding (ortholog); ADP binding (ortholog); INVOLVED IN acetyl-CoA catabolic process (ortholog); apoptotic DNA fragmentation (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN adefovir pharmaco kinetics pathway; de novo pyrimidine biosynthetic pathway; E-cadherin signaling pathway; ASSOCIATED WITH breast cancer (ortholog); breast carcinoma (ortholog); Cardiomegaly (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | 17 | 45243588 | 45252135 | Bonobo | 125 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |