| 3127 | Mx1 | MX dynamin like GTPase 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN response to virus; antiviral innate immune response (ortholog); innate immune response (ortholog); ASSOCIATED WITH Chronic Hepatitis C; acute myeloid leukemia (ortholog); alopecia areata (ortholog); FOUND IN nucleus; c ytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 11 | 50269056 | 50294699 | Rat | 280 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1353561 | MX1 | MX dynamin like GTPase 1 | This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene locat ed adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] | 21 | 41420558 | 41459214 | Human | 294 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1552414 | Mx1 | MX dynamin-like GTPase 1 | This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to the influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a deletion or a nonsense mutation that results in a non-functional gene product. [provided by RefSeq, Aug 2015] | 16 | 97248235 | 97264106 | Mouse | 275 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 11887243 | MX1 | MX dynamin like GTPase 1 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); identical protein binding (inferred); INVOLVED IN cellular response to type I interferon (ortholog); endosomal transport (ortholog); negative regulation of intracellular transport of viral material (ortholog); ASSOCI ATED WITH acute myeloid leukemia (ortholog); alopecia areata (ortholog); Animal Disease Models (ortholog); FOUND IN exocytic vesicle (ortholog) | 21 | 27756768 | 27795307 | Bonobo | 63 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12127199 | MX1 | MX dynamin like GTPase 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN antiviral innate immune response (ortholog); cellular response to type I interferon (ortholog); endosomal transport (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); alopecia areata (ortholog); Animal Dise ase Models (ortholog); FOUND IN cytoplasm; exocytic vesicle; cytosol (ortholog) | 31 | 35898206 | 35929802 | Dog | 60 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18646638 | MX1 | MX dynamin like GTPase 1 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); identical protein binding (inferred); INVOLVED IN cellular response to type I interferon (ortholog); endosomal transport (ortholog); negative regulation of intracellular transport of viral material (ortholog); ASSOCI ATED WITH acute myeloid leukemia (ortholog); alopecia areata (ortholog); Animal Disease Models (ortholog); FOUND IN exocytic vesicle (ortholog) | | | | Green Monkey | 62 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 285056869 | mx1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14285457 | MX1 | MX dynamin like GTPase 1 | ENCODES a protein that exhibits GTPase activity; INVOLVED IN cellular response to type I interferon; defense response to virus; endosomal transport; ASSOCIATED WITH acute myeloid leukemia (ortholog); alopecia areata (ortholog); Animal Disease Models (ortholog); FOUND IN cytoplasm; exocytic vesicle ( ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 70 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 284507151 | mx1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 16554061 | MX1-AS1 | MX1 antisense RNA 1 | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, lncrna |
| 329950494 | MX1-AS1 | MX1 antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 12662572 | LOC101971789 | interferon-induced GTP-binding protein Mx1 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); identical protein binding (inferred); INVOLVED IN antiviral innate immune response (inferred); defense response to virus (inferred); interleukin-27-mediated signaling pathway (inferred); FOUND IN cytoplasm (inferred) ; cytosol (inferred); membrane (inferred) | NW_004936500 | 2332140 | 2353650 | Squirrel | 28 | old_gene_name , name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 9042685 | LOC102022785 | interferon-induced GTP-binding protein Mx1 | | NW_004955407 | 40884281 | 40906469 | Chinchilla | | name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 625994332 | LOC116898940 | interferon-induced GTP-binding protein Mx1 | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 18936820 | LOC106007601 | interferon-induced GTP-binding protein Mx1-like | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); microtubule binding (inferred); INVOLVED IN defense response to virus (inferred); receptor internalization (inferred); response to virus (inferred); FOUND IN cytoplasm (inferred); membrane (inferred); microtubule (in ferred) | | | | Naked Mole-Rat | 17 | name | gene, protein-coding, MODEL [RefSeq] |
| 16566011 | AC006499.8 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16558916 | AC006499.4 | pseudogene similar to part of myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1) | | | | | Human | | name | gene, processed_pseudogene |
| 16559190 | AC006499.5 | pseudogene similar to part of myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1) | | 4 | 10292191 | 10292772 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16559213 | AC006499.7 | pseudogene similar to part of myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1) | | 4 | 10294459 | 10295546 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 18917919 | LOC101716694 | interferon-induced GTP-binding protein Mx2 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); microtubule binding (inferred); INVOLVED IN defense response to virus (inferred); receptor internalization (inferred); response to virus (inferred); FOUND IN cytoplasm (inferred); membrane (inferred); microtubule (in ferred) | | | | Naked Mole-Rat | 18 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 733334 | TRPC5 | transient receptor potential cation channel subfamily C member 5 | This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010] | X | 111768011 | 112082776 | Human | 148 | description | gene, protein-coding, REVIEWED [RefSeq] |
