Gene: TRPC5 (transient receptor potential cation channel subfamily C member 5) Homo sapiens
Symbol: TRPC5
Name: transient receptor potential cation channel subfamily C member 5
Description: This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hTRP5; PPP1R159; short transient receptor potential channel 5; transient receptor potential cation channel, subfamily C, member 5; transient receptor potential channel 5; transient receptor protein 5; TRP-5; TRP5
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X111,774,314 - 112,082,943 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X111,017,542 - 111,326,004 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X110,904,198 - 111,212,660 (-)NCBINCBI36hg18NCBI36
Build 34X110,823,686 - 111,132,149NCBI
CeleraX111,497,049 - 111,805,514 (-)NCBI
Cytogenetic MapXq23NCBI
HuRefX100,639,095 - 100,946,273 (-)NCBIHuRef
CHM1_1X110,928,786 - 111,237,228 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRPC5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733334
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-05-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.