| 1308956 | Mtf1 | metal-regulatory transcription factor 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN positive regulation of transcription by RNA polymeras e II; cartilage homeostasis (ortholog); cellular response to zinc ion (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,6-dinitrotoluene; acetamide; acrylamide | 5 | 142347024 | 142391810 | Rat | 234 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319031 | MTF1 | metal regulatory transcription factor 1 | This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy me tal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008] | 1 | 37809574 | 37859592 | Human | 226 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1319032 | Mtf1 | metal response element binding transcription factor 1 | Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone acetyltransferase binding activity. Involved in DNA-templated transcription and cellular response to zinc ion. Acts upstream of or within positive regulation of transcription by RNA polymerase II; response to cadmium ion; and response to oxidative stress. Located in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and gut. Orthologous to human MTF1 (metal regulatory transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 124696342 | 124743593 | Mouse | 257 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8957313 | Mtf1 | metal regulatory transcription factor 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN cartilage homeostasis (ortholog); cellular response t o zinc ion (ortholog); DNA-templated transcription (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955452 | 15580460 | 15627844 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11903655 | MTF1 | metal regulatory transcription factor 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN cartilage homeostasis (ortholog); positive regulation of DNA-templated transcriptio n (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | 1 | 37088744 | 37134318 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12369102 | MTF1 | metal regulatory transcription factor 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN cartilage homeostasis (ortholog); positive regulation of DNA-templated transcriptio n (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | 15 | 4679945 | 4723111 | Dog | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12642534 | Mtf1 | metal regulatory transcription factor 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN cartilage homeostasis (ortholog); positive regulation of DNA-templated transcriptio n (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936474 | 19981483 | 20027541 | Squirrel | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18924391 | Mtf1 | metal regulatory transcription factor 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); histone acetyltransferase binding (ortholog); INVOLVED IN cartilage homeostasis (ortholog); cellular response to zinc i on (ortholog); DNA-templated transcription (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 598153249 | MTF1 | | | | | | Yeast | | symbol | gene, null |
| 18467441 | MTF1 | metal regulatory transcription factor 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN cartilage homeostasis (ortholog); positive regulation of DNA-templated transcriptio n (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625854690 | Mtf1 | metal regulatory transcription factor 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN cartilage homeostasis (ortholog); cellular response t o zinc ion (ortholog); DNA-templated transcription (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13870293 | MTF1 | metal regulatory transcription factor 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN cartilage homeostasis (ortholog); positive regulation of DNA-templated transcriptio n (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 38 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155259012 | mtf1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 598154113 | MTF1 | | | | | | Yeast | | symbol | gene, null |
| 155241992 | mtf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1317764 | MELTF | melanotransferrin | The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the s ame region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008] | 3 | 197001740 | 197029817 | Human | 104 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312603 | MYT1 | myelin transcription factor 1 | The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008] | 20 | 64164452 | 64242253 | Human | 112 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |