| 735084 | Megf10 | multiple EGF-like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (ortholog); Notch binding (ortholog); scavenger receptor activity (ortholog); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); homotypic cell-cell adhesion (ortholog); A SSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN phagocytic cup (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride | 18 | 52803292 | 52953431 | Rat | 144 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1558549 | Megf10 | multiple EGF-like-domains 10 | Enables Notch binding activity. Involved in several processes, including myoblast development; positive regulation of myoblast proliferation; and skeletal muscle satellite cell proliferation. Acts upstream of or within apoptotic process involved in development; engulfment of apoptotic cell; and reco gnition of apoptotic cell. Located in phagocytic cup. Is expressed in several structures, including brain; heart; retina layer; skeletal muscle tissue; and testis. Human ortholog(s) of this gene implicated in congenital myopathy 10B and early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 57266162 | 57430539 | Mouse | 143 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1601732 | MEGF10 | multiple EGF like domains 10 | This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012] | 5 | 127229300 | 127461222 | Human | 228 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8988044 | Megf10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (ortholog); Notch binding (ortholog); scavenger receptor activity (ortholog); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); homotypic cell-cell adhesion (ortholog); A SSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN phagocytic cup (ortholog); plasma membrane (ortholog) | NW_004955415 | 393642 | 513157 | Chinchilla | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11674886 | MEGF10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (inferred); Notch binding (inferred); scavenger receptor activity (inferred); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); recognition of apoptotic cell (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN membrane (inferred); phagocytic cup (inferred); plasma membrane (inferred) | 5 | 122639155 | 122877324 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12339532 | MEGF10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (inferred); Notch binding (inferred); scavenger receptor activity (inferred); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); recognition of apoptotic cell (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN phagocytic cup (inferred); plasma membrane (inferred) | 11 | 16359648 | 16574882 | Dog | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12567366 | Megf10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (inferred); Notch binding (inferred); scavenger receptor activity (inferred); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); recognition of apoptotic cell (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN membrane (inferred); phagocytic cup (inferred); plasma membrane (inferred) | NW_004936504 | 634167 | 753438 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911993 | Megf10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (ortholog); scavenger receptor activity (ortholog); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); homotypic cell-cell adhesion (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN membrane (inferred); phagocytic cup (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13921442 | MEGF10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (inferred); Notch binding (inferred); scavenger receptor activity (inferred); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); recognition of apoptotic cell (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN phagocytic cup (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18788158 | MEGF10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (inferred); Notch binding (inferred); scavenger receptor activity (inferred); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); recognition of apoptotic cell (ortholog); ASSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN membrane (inferred); phagocytic cup (inferred); plasma membrane (inferred) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626037433 | Megf10 | multiple EGF like domains 10 | ENCODES a protein that exhibits complement component C1q complex binding (ortholog); Notch binding (ortholog); scavenger receptor activity (ortholog); INVOLVED IN apoptotic process involved in development (ortholog); engulfment of apoptotic cell (ortholog); homotypic cell-cell adhesion (ortholog); A SSOCIATED WITH congenital myopathy 10B (ortholog); Deglutition Disorders (ortholog); early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ortholog); FOUND IN phagocytic cup (ortholog); plasma membrane (ortholog) | | | | Black Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245058 | megf10 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155259188 | megf10.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155245057 | megf10.S | | | | | | African Clawed Frog | | symbol | gene, null |
