| 3060 | Mcm4 | minichromosome maintenance complex component 4 | ENCODES a protein that exhibits DNA helicase activity (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN DNA replication (ortholog); PARTICIPATES IN cell cycle pathway, mitotic; DNA replication pathway; ASSOCIATED WITH immunodeficiency 54 (ortholog); microcephaly (ortholog); FOUND IN MC M complex (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 11 | 98762599 | 98776300 | Rat | 255 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 735578 | MCM4 | minichromosome maintenance complex component 4 | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may b e involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] | 8 | 47960941 | 47978160 | Human | 300 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 735579 | Mcm4 | minichromosome maintenance complex component 4 | Enables single-stranded DNA binding activity. Contributes to DNA helicase activity. Acts upstream of or within DNA replication. Part of MCM complex. Is expressed in several structures, including brain; future brain; limb; metanephros; and myocardium layer. Human ortholog(s) of this gene implicated i n immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 15441761 | 15455264 | Mouse | 315 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9044132 | Mcm4 | minichromosome maintenance complex component 4 | ENCODES a protein that exhibits DNA helicase activity (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH immunodeficiency 54 (ortholog); microcephaly (ortholog); FOUND IN CMG complex (ortholog); MCM complex (ortholog); nucleoplasm (ortholog) | NW_004955454 | 7891646 | 7908240 | Chinchilla | 31 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11978535 | MCM4 | minichromosome maintenance complex component 4 | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); DNA binding (inferred); INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH immunodeficiency 54 (ortholog); microcephaly (ortholog); FOUND IN chromosome (inferred); MCM complex (inferred); nucleoplasm (in ferred) | 8 | 44387529 | 44404773 | Bonobo | 51 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12209120 | MCM4 | minichromosome maintenance complex component 4 | ENCODES a protein that exhibits ATP binding (inferred); DNA binding (inferred); DNA helicase activity (inferred); INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH immunodeficiency 54 (ortholog); microcephaly (ortholog); FOUND IN chromosome (inferred); MCM complex (inferred); nucleoplasm (infe rred) | 29 | 244634 | 261154 | Dog | 50 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12683177 | Mcm4 | minichromosome maintenance complex component 4 | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); DNA binding (inferred); INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH immunodeficiency 54 (ortholog); microcephaly (ortholog); FOUND IN chromosome (inferred); MCM complex (inferred); nucleoplasm (in ferred) | NW_004936590 | 4705028 | 4722320 | Squirrel | 52 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625904287 | Mcm4 | minichromosome maintenance complex component 4 | ENCODES a protein that exhibits DNA helicase activity (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH immunodeficiency 54 (ortholog); microcephaly (ortholog); FOUND IN CMG complex (ortholog); MCM complex (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 31 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18657684 | MCM4 | minichromosome maintenance complex component 4 | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); DNA binding (inferred); INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH immunodeficiency 54 (ortholog); microcephaly (ortholog); FOUND IN chromosome (inferred); MCM complex (inferred); nucleoplasm (in ferred) | | | | Green Monkey | 51 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13990796 | MCM4 | minichromosome maintenance complex component 4 | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); DNA binding (inferred); INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH immunodeficiency 54 (ortholog); microcephaly (ortholog); FOUND IN chromosome (inferred); MCM complex (inferred); nucleoplasm (in ferred) | | | | Pig | 51 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18922992 | Mcm4 | minichromosome maintenance complex component 4 | ENCODES a protein that exhibits DNA helicase activity (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH immunodeficiency 54 (ortholog); microcephaly (ortholog); FOUND IN CMG complex (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 52 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155254497 | mcm4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14380524 | MCM4 | | | | | | Yeast | | symbol | gene, null |
| 155252768 | mcm4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254498 | mcm4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1563943 | Mcm4-ps1 | minichromosome maintenance complex component 4, pseudogene 1 | | 2 | 143696340 | 143704646 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 12202890 | LOC102154227 | DNA replication licensing factor MCM4-like | | 32 | 16239524 | 16250093 | Dog | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 18926955 | LOC101697612 | DNA replication licensing factor MCM4 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 13943567 | LOC102163361 | DNA replication licensing factor MCM4 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 1313689 | MCM2 | minichromosome maintenance complex component 2 | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012] | 3 | 127598411 | 127622436 | Human | 363 | description | gene, protein-coding, REVIEWED [RefSeq] |
