Map3k7ip1 Gene Search Result

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5 records found for search term Map3k7ip1

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1306216	Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	ENCODES a protein that exhibits MAP kinase kinase kinase activity; mitogen-activated protein kinase p38 binding; protein-containing complex binding; INVOLVED IN positive regulation of MAP kinase activity; aorta development (ortholog); canonical NF-kappaB signal transduction (ortholog); PARTICIPATES ... (more) IN Bone morphogenetic proteins signaling pathway; interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH polycystic ovary syndrome (ortholog); FOUND IN protein-containing complex; cytoplasm (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil	7	113556157	113587351	Rat	124	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
1314707	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1	The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has b ... (more) een shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]	22	39399780	39437132	Human	140	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1314708	Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	Enables kinase activator activity. Acts upstream of or within several processes, including circulatory system development; positive regulation of MAPK cascade; and transforming growth factor beta receptor signaling pathway. Predicted to be located in nuclear speck. Predicted to be part of protein-co ... (more) ntaining complex. Predicted to be active in cytosol and endoplasmic reticulum membrane. Is expressed in brain and genitourinary system. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]	15	80017333	80045908	Mouse	173	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
12391022	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1	ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); mitogen-activated protein kinase p38 binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN aorta development (ortholog); cardiac septum development (ortholog); coronary vasculature development (ort ... (more) holog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH polycystic ovary syndrome (ortholog); FOUND IN protein-containing complex (ortholog)	10	25623381	25657630	Dog	68	old_gene_symbol	gene, protein-coding, MODEL [RefSeq]
619564	MAPK14	mitogen-activated protein kinase 14	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is a ... (more) ctivated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]	6	36027808	36124214	Human	894	description	gene, protein-coding, REVIEWED [RefSeq]