| 3042 | Map1a | microtubule-associated protein 1A | ENCODES a protein that exhibits actin binding; collagen binding; microtubule binding; INVOLVED IN negative regulation of microtubule depolymerization; anterograde axonal protein transport (ortholog); associative learning (ortholog); ASSOCIATED WITH hypothyroidism; genetic disease (ortholog); FOUND I N axon; cytoplasm; dendrite; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione | 3 | 128716907 | 128736638 | Rat | 183 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736437 | MAP1A | microtubule associated protein 1A | This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008] | 15 | 43510954 | 43531611 | Human | 169 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736438 | Map1a | microtubule-associated protein 1 A | Enables cytoskeletal anchor activity; cytoskeletal protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including axo-dendritic protein transport; learning or memory; and regulation of protein localization. Acts upstream of or within photorecep tor cell maintenance and sensory perception of sound. Located in several cellular components, including axon initial segment; dendritic microtubule; and postsynaptic density. Is expressed in cerebral cortex marginal zone; cortical plate; cortical subplate; and spinal cord. Orthologous to human MAP1A (microtubule associated protein 1A). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 121119608 | 121141313 | Mouse | 184 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8853376 | Map1a | microtubule associated protein 1A | ENCODES a protein that exhibits actin binding (ortholog); collagen binding (ortholog); cytoskeletal anchor activity (ortholog); INVOLVED IN anterograde axonal protein transport (ortholog); associative learning (ortholog); memory (ortholog); ASSOCIATED WITH genetic disease (ortholog); hypothyroidism (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); cytoplasm (ortholog) | NW_004955416 | 10052964 | 10073318 | Chinchilla | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11806768 | MAP1A | microtubule associated protein 1A | ENCODES a protein that exhibits actin binding (ortholog); collagen binding (ortholog); cytoskeletal anchor activity (ortholog); INVOLVED IN anterograde axonal protein transport (ortholog); associative learning (ortholog); memory (ortholog); ASSOCIATED WITH genetic disease (ortholog); hypothyroidism (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); cytoplasm (ortholog) | 15 | 22472641 | 22493293 | Bonobo | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12247464 | MAP1A | microtubule associated protein 1A | ENCODES a protein that exhibits actin binding (ortholog); collagen binding (ortholog); cytoskeletal anchor activity (ortholog); INVOLVED IN anterograde axonal protein transport (ortholog); associative learning (ortholog); memory (ortholog); ASSOCIATED WITH genetic disease (ortholog); hypothyroidism (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); cytoplasm (ortholog) | 30 | 10361871 | 10382780 | Dog | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12515388 | Map1a | microtubule associated protein 1A | ENCODES a protein that exhibits actin binding (ortholog); collagen binding (ortholog); cytoskeletal anchor activity (ortholog); INVOLVED IN anterograde axonal protein transport (ortholog); associative learning (ortholog); memory (ortholog); ASSOCIATED WITH genetic disease (ortholog); hypothyroidism (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); cytoplasm (ortholog) | NW_004936471 | 6685565 | 6706860 | Squirrel | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626034523 | Map1a | microtubule associated protein 1A | ENCODES a protein that exhibits actin binding (ortholog); collagen binding (ortholog); cytoskeletal anchor activity (ortholog); INVOLVED IN anterograde axonal protein transport (ortholog); associative learning (ortholog); memory (ortholog); ASSOCIATED WITH genetic disease (ortholog); hypothyroidism (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); cytoplasm (ortholog) | | | | Black Rat | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18770775 | MAP1A | microtubule associated protein 1A | ENCODES a protein that exhibits actin binding (ortholog); collagen binding (ortholog); cytoskeletal anchor activity (ortholog); INVOLVED IN anterograde axonal protein transport (ortholog); associative learning (ortholog); memory (ortholog); ASSOCIATED WITH genetic disease (ortholog); hypothyroidism (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); cytoplasm (ortholog) | | | | Green Monkey | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922727 | Map1a | microtubule associated protein 1A | ENCODES a protein that exhibits actin binding (ortholog); collagen binding (ortholog); cytoskeletal anchor activity (ortholog); INVOLVED IN anterograde axonal protein transport (ortholog); associative learning (ortholog); memory (ortholog); ASSOCIATED WITH genetic disease (ortholog); hypothyroidism (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); cytoplasm (ortholog) | | | | Naked Mole-Rat | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14149675 | MAP1A | microtubule associated protein 1A | ENCODES a protein that exhibits actin binding (ortholog); collagen binding (ortholog); cytoskeletal anchor activity (ortholog); INVOLVED IN anterograde axonal protein transport (ortholog); associative learning (ortholog); memory (ortholog); ASSOCIATED WITH genetic disease (ortholog); hypothyroidism (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); cytoplasm (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284575338 | map1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 284575021 | map1a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288056994 | map1a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1313634 | METAP1 | methionyl aminopeptidase 1 | Enables aminopeptidase activity. Involved in protein maturation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 98995721 | 99062809 | Human | 85 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1350223 | MAP1LC3B | microtubule associated protein 1 light chain 3 beta | The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that i nvolves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008] | 16 | 87392336 | 87404774 | Human | 1050 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1551009 | Map1lc3b | microtubule-associated protein 1 light chain 3 beta | Predicted to enable several functions, including microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Involved in autophagy. Acts upstream of or within positive regulation of mucus secretion. Located in axoneme; membrane; and vacuole . Is expressed in several structures, including central nervous system; heart; limb; peripheral nervous system ganglion; and sensory organ. Orthologous to several human genes including MAP1LC3B (microtubule associated protein 1 light chain 3 beta). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 122317177 | 122325499 | Mouse | 1002 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735183 | Map1lc3a | microtubule-associated protein 1 light chain 3 alpha | ENCODES a protein that exhibits phospholipid binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN autophagosome assembly; autophagy; cellular response to amino acid starvation; PARTICIPATES IN autophagy pathway; ASSOCIATED WITH acute myocardial infarction; Brain Hypoxia-Ische mia; Brain Injuries; FOUND IN autophagosome; autophagosome membrane; cytoplasm; INTERACTS WITH 1,3-dichloropropan-2-ol; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol | 3 | 164243204 | 164244850 | Rat | 365 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1332294 | Map1lc3a | microtubule-associated protein 1 light chain 3 alpha | Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to nitrogen starvation; intracellular signaling cassette; and macroautophagy. Predicted to act upstream of or with in autophagy of mitochondrion. Located in autophagosome membrane. Is expressed in several structures, including central nervous system; heart; jaw; peripheral nervous system ganglion; and sensory organ. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 155118284 | 155119993 | Mouse | 384 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1347480 | MAP1LC3A | microtubule associated protein 1 light chain 3 alpha | MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light ch ain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012] | 20 | 34546844 | 34560345 | Human | 390 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 621315 | Map1lc3b | microtubule-associated protein 1 light chain 3 beta | ENCODES a protein that exhibits microtubule binding; protein domain specific binding; tubulin binding; INVOLVED IN positive regulation of protein binding; autophagosome assembly (ortholog); autophagosome maturation (ortholog); PARTICIPATES IN autophagy pathway; ASSOCIATED WITH Myocardial Ischemia; T emporomandibular Joint Osteoarthritis; Chemical and Drug Induced Liver Injury (ortholog); FOUND IN autophagosome membrane; axon; dendrite; INTERACTS WITH 1,3-dichloropropan-2-ol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine | 19 | 66571631 | 66582270 | Rat | 1000 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1606859 | MAP1LC3C | microtubule associated protein 1 light chain 3 gamma | Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010] | 1 | 241995490 | 242001393 | Human | 75 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2301276 | MAP1LC3B2 | microtubule associated protein 1 light chain 3 beta 2 | Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Predicted to be located in several cellular components, including cytop lasmic vesicle; endomembrane system; and microtubule. Predicted to be active in autophagosome membrane. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 116559381 | 116576606 | Human | 52 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |