| 3009 | Lipc | lipase C, hepatic type | ENCODES a protein that exhibits acetylesterase activity; acyltransferase activity; apolipoprotein binding; INVOLVED IN cellular response to cAMP; cellular response to hormone stimulus; chylomicron remnant clearance; PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency p athway; glycerol kinase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury; end stage renal disease; Experimental Diabetes Mellitus; FOUND IN cell surface; early endosome; extracellular space; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 8 | 80390470 | 80516463 | Rat | 388 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10871 | Lipc | lipase, hepatic | Enables lipase activity. Acts upstream of or within cholesterol homeostasis; cholesterol metabolic process; and cholesterol transport. Located in extracellular space. Is expressed in chondrocranium; femur; liver; liver lobe; and spleen. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; familial combined hyperlipidemia; glucose metabolism disease (multiple); obesity; and peripheral vascular disease. Orthologous to human LIPC (lipase C, hepatic type). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 70705410 | 70859503 | Mouse | 419 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736877 | LIPC | lipase C, hepatic type | Enables phospholipase A1 activity and triacylglycerol lipase activity. Involved in several processes, including cholesterol homeostasis; plasma lipoprotein particle remodeling; and triglyceride catabolic process. Located in extracellular space. Implicated in several diseases, including Alzheimer's d isease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Biomarker of hyperinsulinism; obesity; and type 1 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025] | 15 | 58431991 | 58569844 | Human | 427 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8881412 | Lipc | lipase C, hepatic type | ENCODES a protein that exhibits acetylesterase activity (ortholog); acyltransferase activity (ortholog); apolipoprotein binding (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to hormone stimulus (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN D-glycer icacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog) | NW_004955450 | 15947869 | 16062449 | Chinchilla | 138 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11996345 | LIPC | lipase C, hepatic type | ENCODES a protein that exhibits acetylesterase activity (ortholog); acyltransferase activity (ortholog); apolipoprotein binding (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to hormone stimulus (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN D-glycer icacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog) | 15 | 37363507 | 37537723 | Bonobo | 145 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12159133 | LIPC | lipase C, hepatic type | ENCODES a protein that exhibits acetylesterase activity (ortholog); acyltransferase activity (ortholog); apolipoprotein binding (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to hormone stimulus (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN D-glycer icacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog) | 30 | 23432460 | 23584037 | Dog | 148 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12465734 | Lipc | lipase C, hepatic type | ENCODES a protein that exhibits acetylesterase activity (ortholog); acyltransferase activity (ortholog); apolipoprotein binding (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to hormone stimulus (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN D-glycer icacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog) | NW_004936471 | 19604083 | 19733721 | Squirrel | 145 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935570 | Lipc | lipase C, hepatic type | ENCODES a protein that exhibits acetylesterase activity (ortholog); acyltransferase activity (ortholog); apolipoprotein binding (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to hormone stimulus (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN D-glycer icacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 147 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625996538 | Lipc | lipase C, hepatic type | ENCODES a protein that exhibits acetylesterase activity (ortholog); acyltransferase activity (ortholog); apolipoprotein binding (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to hormone stimulus (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN D-glycer icacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Albuminuria (ortholog); Chemical and Drug Induced Liver Injury (ortholog); coronary artery disease (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog) | | | | Black Rat | 138 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18704943 | LIPC | lipase C, hepatic type | ENCODES a protein that exhibits acetylesterase activity (ortholog); acyltransferase activity (ortholog); apolipoprotein binding (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to hormone stimulus (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN D-glycer icacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog) | | | | Green Monkey | 145 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13847054 | LIPC | lipase C, hepatic type | ENCODES a protein that exhibits acetylesterase activity (ortholog); acyltransferase activity (ortholog); apolipoprotein binding (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to hormone stimulus (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN D-glycer icacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog) | | | | Pig | 148 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155252826 | lipc | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155252827 | lipc.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255252 | lipc.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 11084824 | LIPC-AS1 | LIPC antisense RNA 1 | INTERACTS WITH benzo[e]pyrene; methapyrilene | 15 | 58434901 | 58498735 | Human | 2 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16562230 | AC018904.2 | novel transcript, sense intronic to LIPC | | | | | Human | | name | gene, lncrna |
| 16568141 | AC084781.1 | novel transcript, sense intronic to LIPC | | | | | Human | | name | gene, lncrna |
| 16568344 | AC084781.2 | novel transcript, sense intronic to LIPC | | | | | Human | | name | gene, lncrna |