| 68398 | Kcnh1 | potassium voltage-gated channel subfamily H member 1 | ENCODES a protein that exhibits 14-3-3 protein binding; calmodulin binding; delayed rectifier potassium channel activity; INVOLVED IN cellular response to calcium ion; monoatomic ion transmembrane transport; potassium ion transmembrane transport; ASSOCIATED WITH Breast Neoplasms (ortholog); colorect al adenocarcinoma (ortholog); Developmental Disease (ortholog); FOUND IN axolemma; axon; cell surface; INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; amitrole | 13 | 106253101 | 106555712 | Rat | 194 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 68584 | KCNH1 | potassium voltage-gated channel subfamily H member 1 | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte tran sport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] | 1 | 210678314 | 211134148 | Human | 344 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 68585 | Kcnh1 | potassium voltage-gated channel, subfamily H (eag-related), member 1 | Enables delayed rectifier potassium channel activity and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in potassium ion transmembrane transport; regulation of presynaptic cytosolic calcium ion concentration; and regulation of synapti c vesicle exocytosis. Located in plasma membrane. Is active in parallel fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 191871759 | 192192467 | Mouse | 212 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8751829 | Kcnh1 | potassium voltage-gated channel subfamily H member 1 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); calmodulin binding (ortholog); cyclic nucleotide binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); monoatomic ion transmembrane transport (ortholog); potassium ion transmembrane transport (ortholog); ASSOCI ATED WITH Breast Neoplasms (ortholog); colorectal adenocarcinoma (ortholog); Developmental Disease (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | NW_004955489 | 1176615 | 1549880 | Chinchilla | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11832594 | KCNH1 | potassium voltage-gated channel subfamily H member 1 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); cyclic nucleotide binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); monoatomic ion transmembrane transport (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); colorectal adenocarcinoma (ortholog); Developmental Disease (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | 1 | 186233881 | 186696509 | Bonobo | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12177302 | KCNH1 | potassium voltage-gated channel subfamily H member 1 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); cyclic nucleotide binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); monoatomic ion transmembrane transport (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); colorectal adenocarcinoma (ortholog); Developmental Disease (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | 7 | 9317804 | 9631144 | Dog | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12455013 | Kcnh1 | potassium voltage-gated channel subfamily H member 1 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); cyclic nucleotide binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); monoatomic ion transmembrane transport (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); colorectal adenocarcinoma (ortholog); Developmental Disease (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | NW_004936557 | 2133596 | 2493170 | Squirrel | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13972119 | KCNH1 | potassium voltage-gated channel subfamily H member 1 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); cyclic nucleotide binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); monoatomic ion transmembrane transport (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); colorectal adenocarcinoma (ortholog); Developmental Disease (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | | | | Pig | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18590164 | KCNH1 | potassium voltage-gated channel subfamily H member 1 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); cyclic nucleotide binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); monoatomic ion transmembrane transport (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); colorectal adenocarcinoma (ortholog); Developmental Disease (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | | | | Green Monkey | 76 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626105898 | Kcnh1 | potassium voltage-gated channel subfamily H member 1 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); calmodulin binding (ortholog); cyclic nucleotide binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); monoatomic ion transmembrane transport (ortholog); potassium ion transmembrane transport (ortholog); ASSOCI ATED WITH Breast Neoplasms (ortholog); colorectal adenocarcinoma (ortholog); Developmental Disease (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | | | | Black Rat | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254450 | kcnh1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18901323 | Kcnh1 | potassium voltage-gated channel subfamily H member 1 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); cyclic nucleotide binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); monoatomic ion transmembrane transport (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); colorectal adenocarcinoma (ortholog); Developmental Disease (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405860370 | kcnh1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626183127 | kcnh1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857753 | kcnh1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626187781 | kcnh1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864655 | kcnh1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857366 | kcnh1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626180294 | kcnh1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860764 | kcnh1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860890 | kcnh1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626171214 | kcnh1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857937 | kcnh1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861804 | kcnh1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6481125 | KCNH1-IT1 | KCNH1 intronic transcript 1 | | 1 | 211132279 | 211133374 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
