| 2865 | Ifnb1 | interferon beta 1 | ENCODES a protein that exhibits chloramphenicol O-acetyltransferase activity (ortholog); cytokine activity (ortholog); cytokine receptor binding (ortholog); INVOLVED IN cellular response to dsDNA; cellular response to dsRNA; cellular response to exogenous dsRNA; PARTICIPATES IN Chagas disease pathwa y; cytokine mediated signaling pathway; hepatitis C pathway; ASSOCIATED WITH Experimental Autoimmune Encephalomyelitis; Experimental Autoimmune Neuritis; proteinuria; FOUND IN extracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A | 5 | 108066650 | 108067487 | Rat | 304 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736615 | IFNB1 | interferon beta 1 | This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In a ddition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015] | 9 | 21077104 | 21077942 | Human | 304 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552719 | Ifnb1 | interferon beta 1, fibroblast | Enables cytokine activity and type I interferon receptor binding activity. Involved in several processes, including negative regulation of Lewy body formation; response to virus; and type I interferon-mediated signaling pathway. Acts upstream of or within several processes, including cellular respon se to dexamethasone stimulus; defense response to bacterium; and negative regulation of osteoclast differentiation. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in COVID-19; cerebral infarction; multiple sclerosis; and retinoblastoma. Orthologous to human IFNB1 (interferon beta 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 88440253 | 88441083 | Mouse | 345 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8947975 | Ifnb1 | interferon beta 1 | ENCODES a protein that exhibits chloramphenicol O-acetyltransferase activity (ortholog); cytokine activity (ortholog); cytokine receptor binding (ortholog); INVOLVED IN adaptive immune response (ortholog); B cell activation involved in immune response (ortholog); B cell proliferation (ortholog); ASS OCIATED WITH amelanotic melanoma (ortholog); anus benign neoplasm (ortholog); Aortic Remodeling (ortholog); FOUND IN extracellular space (ortholog) | NW_004955434 | 23301623 | 23302304 | Chinchilla | 93 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11853352 | IFNB1 | interferon beta 1 | ENCODES a protein that exhibits chloramphenicol O-acetyltransferase activity (ortholog); cytokine activity (ortholog); cytokine receptor binding (ortholog); INVOLVED IN adaptive immune response (ortholog); B cell activation involved in immune response (ortholog); B cell proliferation (ortholog); ASS OCIATED WITH amelanotic melanoma (ortholog); anus benign neoplasm (ortholog); Aortic Remodeling (ortholog); FOUND IN extracellular space (ortholog) | 9 | 20884742 | 20886317 | Bonobo | 93 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12340198 | IFNB1 | interferon beta 1 | ENCODES a protein that exhibits chloramphenicol O-acetyltransferase activity (inferred); cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN adaptive immune response (ortholog); B cell proliferation (ortholog); cell surface receptor signaling pathway via JAK-STAT (ortholo g); ASSOCIATED WITH amelanotic melanoma (ortholog); anus benign neoplasm (ortholog); Aortic Remodeling (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | 11 | 40668295 | 40668855 | Dog | 109 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12456489 | Ifnb1 | interferon beta 1 | ENCODES a protein that exhibits chloramphenicol O-acetyltransferase activity (ortholog); type I interferon receptor binding (ortholog); INVOLVED IN adaptive immune response (ortholog); B cell activation involved in immune response (ortholog); B cell proliferation (ortholog); ASSOCIATED WITH amelanot ic melanoma (ortholog); anus benign neoplasm (ortholog); Aortic Remodeling (ortholog); FOUND IN extracellular space (ortholog) | NW_004936652 | 2736270 | 2736833 | Squirrel | 98 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935421 | Ifnb1 | interferon beta 1 | ENCODES a protein that exhibits chloramphenicol O-acetyltransferase activity (ortholog); type I interferon receptor binding (ortholog); INVOLVED IN adaptive immune response (ortholog); B cell activation involved in immune response (ortholog); B cell proliferation (ortholog); ASSOCIATED WITH amelanot ic melanoma (ortholog); anus benign neoplasm (ortholog); Aortic Remodeling (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 98 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 598133567 | IFNB1 | interferon beta 1 | ENCODES a protein that exhibits type I interferon receptor binding (ortholog); INVOLVED IN adaptive immune response (ortholog); B cell proliferation (ortholog); cell surface receptor signaling pathway via JAK-STAT (ortholog); ASSOCIATED WITH amelanotic melanoma (ortholog); anus benign neoplasm (orth olog); Aortic Remodeling (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14134245 | IFNB1 | interferon beta 1 | ENCODES a protein that exhibits chloramphenicol O-acetyltransferase activity (inferred); cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN adaptive immune response (ortholog); B cell proliferation (ortholog); cell surface receptor signaling pathway via JAK-STAT (ortholo g); ASSOCIATED WITH amelanotic melanoma (ortholog); anus benign neoplasm (ortholog); Aortic Remodeling (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); INTERACTS WITH cadmium nitrate; chloroquine; deoxynivalenol | | | | Pig | 112 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626058229 | Ifnb1 | interferon beta 1 | ENCODES a protein that exhibits chloramphenicol O-acetyltransferase activity (ortholog); cytokine activity (ortholog); cytokine receptor binding (ortholog); INVOLVED IN adaptive immune response (ortholog); B cell activation involved in immune response (ortholog); B cell proliferation (ortholog); ASS OCIATED WITH amelanotic melanoma (ortholog); anus benign neoplasm (ortholog); Aortic Remodeling (ortholog); FOUND IN extracellular space (ortholog) | | | | Black Rat | 93 | symbol | gene, protein-coding, MODEL [RefSeq] |