| 10749 | Htr3a | 5-hydroxytryptamine (serotonin) receptor 3A | Enables identical protein binding activity and ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in inorganic cation transmembrane transport and serotonin receptor signaling pathway. Part of serotonin-activated cation-selective channel co mplex. Is expressed in several structures, including central nervous system; eye; gallbladder; genitourinary system; and gut. Human ortholog(s) of this gene implicated in alcohol dependence; cocaine dependence; heroin dependence; irritable bowel syndrome; and nicotine dependence. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 48810513 | 48822451 | Mouse | 240 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 61818 | Htr3a | 5-hydroxytryptamine receptor 3A | ENCODES a protein that exhibits serotonin-gated monoatomic cation channel activity; identical protein binding (ortholog); ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN behavioral response to ethanol; cellular response to growth factor stimulus; positive regulation of ion transmembrane transporter activity; ASSOCIATED WITH alcohol dependence; alcohol use disorder (ortholog); amphetamine abuse (ortholog); FOUND IN axon; glutamatergic synapse; neuronal cell body; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-bromopropane; 6-propyl-2-thiouracil | 8 | 58138514 | 58150960 | Rat | 211 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731037 | HTR3A | 5-hydroxytryptamine receptor 3A | The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing re sponses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] | 11 | 113975108 | 113990313 | Human | 214 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8853429 | Htr3a | 5-hydroxytryptamine receptor 3A | ENCODES a protein that exhibits identical protein binding (ortholog); ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); serotonin binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cellular response to growth fac tor stimulus (ortholog); positive regulation of ion transmembrane transporter activity (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); cleavage furrow (ortholog); glutamatergic synapse (ortholog) | NW_004955412 | 15589117 | 15602211 | Chinchilla | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11904517 | HTR3A | 5-hydroxytryptamine receptor 3A | ENCODES a protein that exhibits serotonin-gated monoatomic cation channel activity (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cellular response to growth factor stimulus (ortholog); positive regulation of ion transmembrane transporter activity (ortholog); ASSOCIATED WITH alco hol dependence (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | 11 | 108851954 | 108869119 | Bonobo | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12271177 | HTR3A | 5-hydroxytryptamine receptor 3A | ENCODES a protein that exhibits serotonin-gated monoatomic cation channel activity (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cellular response to growth factor stimulus (ortholog); positive regulation of ion transmembrane transporter activity (ortholog); ASSOCIATED WITH alco hol dependence (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | 5 | 19324087 | 19338250 | Dog | 65 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 625938308 | Htr3a | 5-hydroxytryptamine receptor 3A | ENCODES a protein that exhibits identical protein binding (ortholog); ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); serotonin binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cellular response to growth fac tor stimulus (ortholog); positive regulation of ion transmembrane transporter activity (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); cleavage furrow (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14096379 | HTR3A | 5-hydroxytryptamine receptor 3A | ENCODES a protein that exhibits serotonin-gated monoatomic cation channel activity (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cellular response to growth factor stimulus (ortholog); positive regulation of ion transmembrane transporter activity (ortholog); ASSOCIATED WITH alco hol dependence (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | | | | Pig | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284294135 | htr3a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18911014 | Htr3a | 5-hydroxytryptamine receptor 3A | ENCODES a protein that exhibits identical protein binding (ortholog); ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); serotonin binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cellular response to growth fac tor stimulus (ortholog); positive regulation of ion transmembrane transporter activity (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); cleavage furrow (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18652526 | HTR3A | 5-hydroxytryptamine receptor 3A | ENCODES a protein that exhibits serotonin-gated monoatomic cation channel activity (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cellular response to growth factor stimulus (ortholog); positive regulation of ion transmembrane transporter activity (ortholog); ASSOCIATED WITH alco hol dependence (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | | | | Green Monkey | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284986944 | htr3a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626182410 | htr3a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626171853 | htr3a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860372 | htr3a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864830 | htr3a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864394 | htr3a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856279 | htr3a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12608460 | Htr3b | 5-hydroxytryptamine receptor 3B | ENCODES a protein that exhibits extracellular ligand-gated monoatomic ion channel activity (inferred); ligand-gated monoatomic ion channel activity (inferred); monoatomic ion channel activity (inferred); INVOLVED IN cellular response to growth factor stimulus (ortholog); positive regulation of ion t ransmembrane transporter activity (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); Cocaine-Related Disorders (ortholog); depressive disorder (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog) | NW_004936612 | 631995 | 712037 | Squirrel | 27 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 730958 | HTR3B | 5-hydroxytryptamine receptor 3B | The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing re sponses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011] | 11 | 113898923 | 113949079 | Human | 78 | description | gene, protein-coding, REVIEWED [RefSeq] |
