| 620913 | Hsf1 | heat shock transcription factor 1 | ENCODES a protein that exhibits heat shock protein binding; promoter-specific chromatin binding; sequence-specific single stranded DNA binding; INVOLVED IN cellular response to amino acid stimulus; cellular response to angiotensin; cellular response to estradiol stimulus; ASSOCIATED WITH Alzheimer's disease; Cardiomegaly; congestive heart failure; FOUND IN euchromatin; heterochromatin; centrosome (ortholog); INTERACTS WITH (+)-schisandrin B; (R)-adrenaline; (Z)-ligustilide | 7 | 110076710 | 110103665 | Rat | 519 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 730995 | HSF1 | heat shock transcription factor 1 | The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock pro tein 90. [provided by RefSeq, Jul 2017] | 8 | 144291604 | 144314720 | Human | 507 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 730996 | Hsf1 | heat shock factor 1 | Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of gene expression. Acts upstream of or within several processes, including embryo development; negative regulation of tumor necrosis factor production; and response to lipopolysaccharide. Located in cytoplasm and pronucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 76361562 | 76385355 | Mouse | 656 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8816156 | Hsf1 | heat shock transcription factor 1 | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to angiotensin (ortholog); cellular response to cadmium ion (ortholog); ASSOCIATED WITH Alzheimer 's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Cardiomegaly (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955454 | 2907265 | 2932352 | Chinchilla | 160 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12022788 | HSF1 | heat shock transcription factor 1 | ENCODES a protein that exhibits heat shock protein binding (ortholog); promoter-specific chromatin binding (ortholog); sequence-specific single stranded DNA binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to angiotensin (ortholog); cellular resp onse to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Cardiomegaly (ortholog); FOUND IN euchromatin (ortholog); heterochromatin (ortholog) | 8 | 141055310 | 141078360 | Bonobo | 160 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12078088 | HSF1 | heat shock transcription factor 1 | ENCODES a protein that exhibits heat shock protein binding (ortholog); promoter-specific chromatin binding (ortholog); sequence-specific single stranded DNA binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to angiotensin (ortholog); cellular resp onse to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Cardiomegaly (ortholog); FOUND IN euchromatin (ortholog); heterochromatin (ortholog) | 13 | 37724741 | 37745259 | Dog | 163 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12543341 | Hsf1 | heat shock transcription factor 1 | ENCODES a protein that exhibits heat shock protein binding (ortholog); promoter-specific chromatin binding (ortholog); sequence-specific single stranded DNA binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to angiotensin (ortholog); cellular resp onse to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Cardiomegaly (ortholog); FOUND IN euchromatin (ortholog); heterochromatin (ortholog) | NW_004936470 | 7927734 | 7950805 | Squirrel | 160 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928607 | Hsf1 | heat shock transcription factor 1 | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to angiotensin (ortholog); cellular response to cadmium ion (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Cardiomegaly (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Naked Mole-Rat | 161 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247168 | hsf1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18563366 | HSF1 | heat shock transcription factor 1 | ENCODES a protein that exhibits heat shock protein binding (ortholog); promoter-specific chromatin binding (ortholog); sequence-specific single stranded DNA binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to angiotensin (ortholog); cellular resp onse to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Cardiomegaly (ortholog); FOUND IN euchromatin (ortholog); heterochromatin (ortholog) | | | | Green Monkey | 160 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625962795 | Hsf1 | heat shock transcription factor 1 | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to angiotensin (ortholog); cellular response to cadmium ion (ortholog); ASSOCIATED WITH Alzheimer 's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Cardiomegaly (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 160 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14377343 | HSF1 | | | | | | Yeast | | symbol | gene, null |
| 13937316 | HSF1 | heat shock transcription factor 1 | ENCODES a protein that exhibits heat shock protein binding (ortholog); promoter-specific chromatin binding (ortholog); sequence-specific single stranded DNA binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to angiotensin (ortholog); cellular resp onse to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Cardiomegaly (ortholog); FOUND IN euchromatin (ortholog); heterochromatin (ortholog) | | | | Pig | 163 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 405863375 | hsf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859866 | hsf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859715 | hsf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858723 | hsf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359602 | hsf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359595 | hsf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155237812 | hsf1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 736685 | HSBP1 | heat shock factor binding protein 1 | The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008] | 16 | 83807978 | 83819737 | Human | 98 | description | gene, protein-coding, REVIEWED [RefSeq] |
