Hmgcs2 Gene Search Result

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12 records found for search term Hmgcs2

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
2804	Hmgcs2	3-hydroxy-3-methylglutaryl-CoA synthase 2	ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity; identical protein binding (ortholog); INVOLVED IN adipose tissue development; cellular response to amino acid stimulus; cellular response to fatty acid; PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathwa ... (more) y; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus; extrahepatic cholestasis; Hepatomegaly; FOUND IN mitochondrial matrix; mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 17alpha-ethynylestradiol	2	188564348	188590872	Rat	418	symbol , PhenoGen	gene, protein-coding, PROVISIONAL [RefSeq]
10713	Hmgcs2	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Enables hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process; farnesyl diphosphate biosynthetic process, mevalonate pathway; and ketone body biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary syste ... (more) m; cardiovascular system; facial bone primordium; nervous system; and reproductive system. Used to study HMG-CoA synthase 2 deficiency. Human ortholog(s) of this gene implicated in HMG-CoA synthase 2 deficiency. Orthologous to human HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2). [provided by Alliance of Genome Resources, Jul 2025]	3	98187747	98218054	Mouse	481	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
737571	HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2	The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in th ... (more) is gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]	1	119747996	119768932	Human	505	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
8823467	Hmgcs2	3-hydroxy-3-methylglutaryl-CoA synthase 2	ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity (ortholog); identical protein binding (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); adipose tissue development (ortholog); cellular response to amino acid stimulus (ortholog); PARTICIPATES IN 3-hydroxy-3-m ... (more) ethylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Colonic Neoplasms (ortholog); congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog)	NW_004955435	22804484	22820807	Chinchilla	71	symbol	gene, protein-coding, MODEL [RefSeq]
11847066	HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2	ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency ... (more) pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Colonic Neoplasms (ortholog); congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN mitochondrial matrix (ortholog)	1	82778489	82798987	Bonobo	88	symbol	gene, protein-coding, MODEL [RefSeq]
12094098	HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2	ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency ... (more) pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Colonic Neoplasms (ortholog); congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN mitochondrial matrix (ortholog)	17	56679942	56698521	Dog	87	symbol	gene, protein-coding, MODEL [RefSeq]
12542892	Hmgcs2	3-hydroxy-3-methylglutaryl-CoA synthase 2	ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency ... (more) pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Colonic Neoplasms (ortholog); congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN mitochondrial matrix (ortholog)	NW_004936627	4451847	4473163	Squirrel	89	symbol	gene, protein-coding, MODEL [RefSeq]
18655514	HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2	ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency ... (more) pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Colonic Neoplasms (ortholog); congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN mitochondrial matrix (ortholog)				Green Monkey	88	symbol	gene, protein-coding, MODEL [RefSeq]
14010215	HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2	ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity (ortholog); identical protein binding (ortholog); INVOLVED IN ketone body biosynthetic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-meth ... (more) ylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Colonic Neoplasms (ortholog); congestive heart failure (ortholog); genetic disease (ortholog); FOUND IN mitochondrion (inferred); INTERACTS WITH clofibrate				Pig	48	symbol	gene, protein-coding, PROVISIONAL [RefSeq]
18902582	Hmgcs2	3-hydroxy-3-methylglutaryl-CoA synthase 2	ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity (ortholog); identical protein binding (ortholog); INVOLVED IN adipose tissue development (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN 3-hydroxy- ... (more) 3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Colonic Neoplasms (ortholog); congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN mitochondrial matrix (ortholog)				Naked Mole-Rat	87	symbol	gene, protein-coding, MODEL [RefSeq]
625953276	Hmgcs2	3-hydroxy-3-methylglutaryl-CoA synthase 2	ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity (ortholog); identical protein binding (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); adipose tissue development (ortholog); cellular response to amino acid stimulus (ortholog); PARTICIPATES IN 3-hydroxy-3-m ... (more) ethylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Colonic Neoplasms (ortholog); congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog)				Black Rat	71	symbol	gene, protein-coding, MODEL [RefSeq]
14266849	LOC110260333	hydroxymethylglutaryl-CoA synthase, mitochondrial-like	ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN ketone bodies biosynthetic pathway; ASSOCIATED W ... (more) ITH Experimental Diabetes Mellitus (ortholog); extrahepatic cholestasis (ortholog); Hepatomegaly (ortholog); FOUND IN mitochondrial matrix (ortholog)				Pig	59	ensembl_gene_symbol	gene, protein-coding, MODEL [RefSeq]