| 1307527 | Hic1 | HIC ZBTB transcriptional repressor 1 | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); n egative regulation of transcription by RNA polymerase II (ortholog); negative regulation of Wnt signaling pathway (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Gastrointestinal Neoplasms (ortholog); macular degeneration (ortholog); FOUND IN chromatin (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl | 10 | 60512855 | 60517812 | Rat | 133 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1316774 | HIC1 | HIC ZBTB transcriptional repressor 1 | This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010] | 17 | 2055103 | 2063241 | Human | 165 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1316775 | Hic1 | hypermethylated in cancer 1 | Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and sequence-specific double-stranded DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcri ption by RNA polymerase II; and positive regulation of DNA damage response, signal transduction by p53 class mediator. Located in chromatin. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and trophectoderm. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 75052203 | 75059970 | Mouse | 178 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8908971 | Hic1 | HIC ZBTB transcriptional repressor 1 | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); n egative regulation of transcription by RNA polymerase II (ortholog); negative regulation of Wnt signaling pathway (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Gastrointestinal Neoplasms (ortholog); macular degeneration (ortholog); FOUND IN chromatin (ortholog) | NW_004955481 | 1179015 | 1182936 | Chinchilla | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11708993 | HIC1 | HIC ZBTB transcriptional repressor 1 | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); n egative regulation of transcription by RNA polymerase II (ortholog); negative regulation of Wnt signaling pathway (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Gastrointestinal Neoplasms (ortholog); macular degeneration (ortholog); FOUND IN chromatin (ortholog) | 17 | 2045960 | 2051483 | Bonobo | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12230886 | HIC1 | HIC ZBTB transcriptional repressor 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); intrinsic apoptotic signaling pathway in response to DNA damage (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH Breast Neoplasms (ortholog); Gastrointestinal Neoplasms (ortholog); macular degeneration (ortholog); FOUND IN chromatin (inferred); nucleus (inferred) | 9 | 46156909 | 46162849 | Dog | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12595018 | Hic1 | HIC ZBTB transcriptional repressor 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); intrinsic apoptotic signaling pathway in response to DNA damage (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH Breast Neoplasms (ortholog); Gastrointestinal Neoplasms (ortholog); macular degeneration (ortholog); FOUND IN chromatin (inferred); nucleus (inferred) | NW_004936538 | 8122557 | 8126157 | Squirrel | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 152178078 | HIC1 | HIC ZBTB transcriptional repressor 1 | | | | | Naked Mole-Rat | | symbol | gene, protein-coding |
| 626003307 | Hic1 | HIC ZBTB transcriptional repressor 1 | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); n egative regulation of transcription by RNA polymerase II (ortholog); negative regulation of Wnt signaling pathway (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Gastrointestinal Neoplasms (ortholog); macular degeneration (ortholog); FOUND IN chromatin (ortholog) | | | | Black Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18912856 | Hic1 | HIC ZBTB transcriptional repressor 1 | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); INVOLVED IN negative regulation of Wnt signaling pathway (ortholog); positive regulation of DNA damage response, signal transduction by p53 class mediator (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Gastrointestinal Neoplasms (ortholog); macular degeneration (ortholog); FOUND IN chromatin (ortholog) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251543 | hic1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18641101 | HIC1 | HIC ZBTB transcriptional repressor 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); intrinsic apoptotic signaling pathway in response to DNA damage (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH Breast Neoplasms (ortholog); Gastrointestinal Neoplasms (ortholog); macular degeneration (ortholog); FOUND IN chromatin (inferred); nucleus (inferred) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13842500 | HIC1 | HIC ZBTB transcriptional repressor 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); intrinsic apoptotic signaling pathway in response to DNA damage (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH Breast Neoplasms (ortholog); Gastrointestinal Neoplasms (ortholog); macular degeneration (ortholog); FOUND IN chromatin (inferred); nucleus (inferred) | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255015 | hic1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1313307 | HIC2 | HIC ZBTB transcriptional repressor 2 | Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; a nd regulation of immune system process. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 22 | 21417371 | 21451463 | Human | 83 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |