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Gene: HIC2 (HIC ZBTB transcriptional repressor 2) Homo sapiens
Symbol: HIC2
Name: HIC ZBTB transcriptional repressor 2
Description: Exhibits protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Localizes to nucleoplasm; INTERACTS WITH 5-fluorouracil; antirheumatic drug; arsane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hic-2; hic-3; HIC1-related gene on chromosome 22 protein; HRG22; hypermethylated in cancer 2; hypermethylated in cancer 2 protein; KIAA1020; ZBTB30; zinc finger and BTB domain-containing protein 30; ZNF907
Mus musculus (house mouse) : Hic2 (hypermethylated in cancer 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hic2 (HIC ZBTB transcriptional repressor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hic2 (HIC ZBTB transcriptional repressor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HIC2 (HIC ZBTB transcriptional repressor 2)
Canis lupus familiaris (dog) : HIC2 (HIC ZBTB transcriptional repressor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hic2 (HIC ZBTB transcriptional repressor 2)
Sus scrofa (pig) : HIC2 (HIC ZBTB transcriptional repressor 2)
Chlorocebus sabaeus (African green monkey) : HIC2 (HIC ZBTB transcriptional repressor 2)
Heterocephalus glaber (naked mole-rat) : Hic2 (HIC ZBTB transcriptional repressor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2221,417,371 - 21,451,463 (+)EnsemblGRCh38hg38GRCh38
GRCh382221,417,371 - 21,451,463 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372221,771,693 - 21,805,752 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,101,693 - 20,135,752 (+)NCBINCBI36hg18NCBI36
Build 342220,096,246 - 20,130,302NCBI
Celera225,515,817 - 5,524,520 (-)NCBI
Cytogenetic Map22q11.21NCBI
HuRef224,831,266 - 4,839,973 (+)NCBIHuRef
CHM1_12221,772,928 - 21,805,973 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HIC2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313307
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.