| 619932 | Hhex | hematopoietically expressed homeobox | ENCODES a protein that exhibits sequence-specific DNA binding; chromatin binding (ortholog); DNA binding, bending (ortholog); INVOLVED IN cell differentiation; negative regulation of angiogenesis; negative regulation of DNA-templated transcription; PARTICIPATES IN maturity-onset diabetes of the youn g pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic liver disease (ortholog); steatotic liver disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-DNA complex (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride | 1 | 244602945 | 244608532 | Rat | 253 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731855 | Hhex | hematopoietically expressed homeobox | Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation o f angiogenesis; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Acts upstream of or within several processes, including forebrain development; hepaticobiliary system development; and tube morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gut; liver and biliary system; and metanephros. Orthologous to human HHEX (hematopoietically expressed homeobox). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 37423289 | 37429179 | Mouse | 334 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1350411 | HHEX | hematopoietically expressed homeobox | This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008] | 10 | 92689955 | 92695647 | Human | 252 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8999558 | Hhex | hematopoietically expressed homeobox | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding, bending (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); B cell different iation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic liver disease (ortholog); steatotic liver disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-DNA complex (ortholog) | NW_004955425 | 737506 | 742775 | Chinchilla | 92 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11876735 | HHEX | hematopoietically expressed homeobox | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor activity (ortholog); HMG box domain binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); B cell differentiation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic liver disease (ortholog); steatotic liver disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); protein-DNA complex (inferred) | 10 | 89433402 | 89439137 | Bonobo | 96 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12183555 | HHEX | hematopoietically expressed homeobox | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor activity (ortholog); HMG box domain binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); B cell differentiation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic liver disease (ortholog); steatotic liver disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); protein-DNA complex (inferred) | 28 | 7057379 | 7063326 | Dog | 96 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12576728 | Hhex | hematopoietically expressed homeobox | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor activity (ortholog); HMG box domain binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); B cell differentiation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic liver disease (ortholog); steatotic liver disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); protein-DNA complex (inferred) | NW_004936601 | 2137490 | 2143797 | Squirrel | 96 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14271826 | HHEX | hematopoietically expressed homeobox | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor activity (ortholog); HMG box domain binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); B cell differentiation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic liver disease (ortholog); steatotic liver disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); protein-DNA complex (inferred) | | | | Pig | 98 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 18908320 | Hhex | hematopoietically expressed homeobox | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding, bending (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); B cell different iation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic liver disease (ortholog); steatotic liver disease (ortholog); FOUND IN cytoplasm (ortholog); protein-DNA complex (ortholog) | | | | Naked Mole-Rat | 97 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155236382 | hhex | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18659787 | HHEX | hematopoietically expressed homeobox | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor activity (ortholog); HMG box domain binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); B cell differentiation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic liver disease (ortholog); steatotic liver disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); protein-DNA complex (inferred) | | | | Green Monkey | 96 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626161840 | Hhex | hematopoietically expressed homeobox | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding, bending (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); B cell different iation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic liver disease (ortholog); steatotic liver disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-DNA complex (ortholog) | | | | Black Rat | 92 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14384987 | HHEX | | | | | | Fly | | symbol | gene, null |
| 155236383 | hhex.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253500 | hhex.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1609343 | Hhex-rs3 | hematopoietically expressed homeobox, related sequence 3 | | | | | Mouse | | symbol , PhenoGen | gene, protein-coding |
| 13895486 | LOC100514590 | hematopoietically-expressed homeobox protein HHEX pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |