| 621403 | Hey1 | hes-related family bHLH transcription factor with YRPW motif 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to glucocorticoid stimulus; Notch sign aling pathway; angiogenesis (ortholog); PARTICIPATES IN Notch signaling pathway; altered Notch signaling pathway; altered Notch signaling pathway involving promoters; ASSOCIATED WITH Carotid Artery Injuries; diabetes mellitus; amyotrophic lateral sclerosis (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylfuran | 2 | 95003935 | 95006457 | Rat | 266 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 735762 | HEY1 | hes related family bHLH transcription factor with YRPW motif 1 | This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse ar e required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] | 8 | 79764010 | 79767767 | Human | 256 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 735763 | Hey1 | hairy/enhancer-of-split related with YRPW motif 1 | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; nephron development; and regulation of transcription by RNA polym erase II. Acts upstream of or within several processes, including circulatory system development; osteoblast development; and positive regulation of osteoblast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; jaw; and sensory organ. Orthologous to human HEY1 (hes related family bHLH transcription factor with YRPW motif 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 8728419 | 8732098 | Mouse | 341 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8929939 | Hey1 | hes related family bHLH transcription factor with YRPW motif 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN angiogenesis (ortholog); anterior/posterior axis specifi cation (ortholog); aortic valve morphogenesis (ortholog); PARTICIPATES IN altered Notch signaling pathway; altered Notch signaling pathway involving promoters; Notch signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | NW_004955444 | 1498444 | 1502099 | Chinchilla | 96 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11770708 | HEY1 | hes related family bHLH transcription factor with YRPW motif 1 | ENCODES a protein that exhibits identical protein binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); aortic valve morphogenesis (ortholog); arterial endothelial cell differentiation (ortholog); PARTICIPATES IN altered Notch sig naling pathway; altered Notch signaling pathway involving promoters; Notch signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog) | 8 | 76286433 | 76290507 | Bonobo | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12278308 | HEY1 | hes related family bHLH transcription factor with YRPW motif 1 | ENCODES a protein that exhibits identical protein binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); aortic valve morphogenesis (ortholog); arterial endothelial cell differentiation (ortholog); PARTICIPATES IN altered Notch sig naling pathway; altered Notch signaling pathway involving promoters; Notch signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog) | 29 | 27185191 | 27188121 | Dog | 98 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12494787 | Hey1 | hes related family bHLH transcription factor with YRPW motif 1 | ENCODES a protein that exhibits identical protein binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); aortic valve morphogenesis (ortholog); arterial endothelial cell differentiation (ortholog); PARTICIPATES IN altered Notch sig naling pathway; altered Notch signaling pathway involving promoters; Notch signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog) | NW_004936871 | 666961 | 670910 | Squirrel | 99 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14048498 | HEY1 | hes related family bHLH transcription factor with YRPW motif 1 | ENCODES a protein that exhibits identical protein binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); aortic valve morphogenesis (ortholog); arterial endothelial cell differentiation (ortholog); PARTICIPATES IN altered Notch sig naling pathway; altered Notch signaling pathway involving promoters; Notch signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog) | | | | Pig | 105 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625873861 | Hey1 | hes related family bHLH transcription factor with YRPW motif 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN angiogenesis (ortholog); anterior/posterior axis specifi cation (ortholog); aortic valve morphogenesis (ortholog); PARTICIPATES IN altered Notch signaling pathway; altered Notch signaling pathway involving promoters; Notch signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 96 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237958 | hey1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18666592 | HEY1 | hes related family bHLH transcription factor with YRPW motif 1 | ENCODES a protein that exhibits identical protein binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); aortic valve morphogenesis (ortholog); arterial endothelial cell differentiation (ortholog); PARTICIPATES IN altered Notch sig naling pathway; altered Notch signaling pathway involving promoters; Notch signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog) | | | | Green Monkey | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18912513 | Hey1 | hes related family bHLH transcription factor with YRPW motif 1 | ENCODES a protein that exhibits identical protein binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); aortic valve morphogenesis (ortholog); arterial endothelial cell differentiation (ortholog); PARTICIPATES IN altered Notch sig naling pathway; altered Notch signaling pathway involving promoters; Notch signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 99 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237957 | hey1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258169 | hey1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 732737 | NCOA2 | nuclear receptor coactivator 2 | The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate th eir target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] | 8 | 70109782 | 70456446 | Human | 346 | description | gene, protein-coding, REVIEWED [RefSeq] |