HEY1 (hes related family bHLH transcription factor with YRPW motif 1) - Rat Genome Database

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Gene: HEY1 (hes related family bHLH transcription factor with YRPW motif 1) Pan paniscus
Analyze
Symbol: HEY1
Name: hes related family bHLH transcription factor with YRPW motif 1
RGD ID: 11770708
Description: ENCODES a protein that exhibits identical protein binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); aortic valve morphogenesis (ortholog); arterial endothelial cell differentiation (ortholog); PARTICIPATES IN altered Notch signaling pathway; altered Notch signaling pathway involving promoters; Notch signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hairy/enhancer-of-split related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2795,499,395 - 95,503,305 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1871,129,371 - 71,133,453 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0876,286,433 - 76,290,507 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1877,917,206 - 77,921,062 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl877,913,761 - 77,921,201 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
anterior/posterior axis specification  (ISO)
anterior/posterior pattern specification  (IEA)
aortic valve morphogenesis  (ISO)
arterial endothelial cell differentiation  (ISO)
artery development  (ISO)
atrioventricular valve formation  (ISO)
atrioventricular valve morphogenesis  (ISO)
blood vessel development  (ISO)
blood vessel endothelial cell differentiation  (ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac septum morphogenesis  (ISO)
cardiac ventricle morphogenesis  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
circulatory system development  (IEA)
comma-shaped body morphogenesis  (ISO)
dorsal aorta morphogenesis  (ISO)
endocardial cushion morphogenesis  (ISO)
endocardial cushion to mesenchymal transition involved in heart valve formation  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
establishment of epithelial cell polarity  (ISO)
inner ear receptor cell stereocilium organization  (ISO)
labyrinthine layer blood vessel development  (ISO)
mesenchymal cell development  (ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of neuron differentiation  (IEA)
negative regulation of Notch signaling pathway  (IEA)
negative regulation of smooth muscle cell differentiation  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
Notch signaling pathway  (IEA,ISO)
osteoblast development  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (ISO)
regulation of inner ear auditory receptor cell differentiation  (ISO)
regulation of neurogenesis  (IEA)
regulation of vasculogenesis  (ISO)
renal vesicle development  (ISO)
S-shaped body morphogenesis  (ISO)
umbilical cord morphogenesis  (ISO)
ureteric bud morphogenesis  (ISO)
vasculogenesis  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component
cytoplasm  (ISO)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HEY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2795,499,395 - 95,503,305 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1871,129,371 - 71,133,453 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0876,286,433 - 76,290,507 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1877,917,206 - 77,921,062 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl877,913,761 - 77,921,201 (-)Ensemblpanpan1.1panPan2
HEY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38879,764,010 - 79,767,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl879,762,371 - 79,767,857 (-)EnsemblGRCh38hg38GRCh38
GRCh37880,676,245 - 80,680,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36880,838,800 - 80,842,653 (-)NCBINCBI36Build 36hg18NCBI36
Build 34880,838,800 - 80,842,559NCBI
Celera876,680,512 - 76,684,366 (-)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef876,165,779 - 76,169,632 (-)NCBIHuRef
CHM1_1880,728,484 - 80,732,338 (-)NCBICHM1_1
T2T-CHM13v2.0880,195,346 - 80,199,104 (-)NCBIT2T-CHM13v2.0
Hey1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3938,728,419 - 8,732,098 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl38,728,419 - 8,732,316 (-)EnsemblGRCm39 Ensembl
GRCm3838,663,359 - 8,667,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl38,663,359 - 8,667,256 (-)EnsemblGRCm38mm10GRCm38
MGSCv3738,663,359 - 8,667,038 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3638,646,432 - 8,650,059 (-)NCBIMGSCv36mm8
Celera38,666,683 - 8,670,362 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map32.15NCBI
Hey1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8295,003,935 - 95,006,457 (+)NCBIGRCr8
mRatBN7.2293,096,605 - 93,100,316 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl293,095,498 - 93,100,312 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx299,620,837 - 99,623,361 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0297,741,864 - 97,744,388 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0292,798,743 - 92,801,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0295,320,147 - 95,322,701 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl295,320,283 - 95,322,696 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02115,062,450 - 115,064,660 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4295,174,030 - 95,176,430 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1295,119,909 - 95,121,344 (+)NCBI
Celera288,672,179 - 88,674,351 (+)NCBICelera
Cytogenetic Map2q23NCBI
Hey1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554441,498,675 - 1,500,945 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554441,498,444 - 1,502,099 (+)NCBIChiLan1.0ChiLan1.0
HEY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12927,185,191 - 27,188,121 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2927,185,191 - 27,188,121 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2927,458,786 - 27,461,729 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02927,308,721 - 27,311,675 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2927,307,758 - 27,311,736 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12927,354,259 - 27,357,186 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02927,393,148 - 27,396,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02927,749,711 - 27,752,657 (-)NCBIUU_Cfam_GSD_1.0
Hey1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530351,893,528 - 51,897,480 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936871666,938 - 670,916 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936871666,961 - 670,910 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl456,859,663 - 56,863,788 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1456,859,640 - 56,863,807 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2462,080,177 - 62,084,026 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HEY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1875,225,081 - 75,228,941 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl875,224,769 - 75,228,896 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603965,971,543 - 65,975,578 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hey1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474411,462,847 - 11,467,870 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474411,462,865 - 11,466,559 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000035645   ⟹   ENSPPAP00000012977
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl877,913,761 - 77,921,201 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035657   ⟹   ENSPPAP00000012989
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl877,918,384 - 77,920,862 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035658   ⟹   ENSPPAP00000012990
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl877,918,384 - 77,919,468 (-)Ensembl
RefSeq Acc Id: XM_003831283   ⟹   XP_003831331
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2795,499,395 - 95,503,265 (-)NCBI
NHGRI_mPanPan1871,129,371 - 71,133,445 (-)NCBI
Mhudiblu_PPA_v0876,286,433 - 76,290,502 (-)NCBI
PanPan1.1877,917,206 - 77,921,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008956665   ⟹   XP_008954913
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2795,499,395 - 95,503,305 (-)NCBI
NHGRI_mPanPan1871,129,371 - 71,133,453 (-)NCBI
Mhudiblu_PPA_v0876,286,433 - 76,290,507 (-)NCBI
PanPan1.1877,917,206 - 77,921,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024929951   ⟹   XP_024785719
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2795,499,395 - 95,501,673 (-)NCBI
NHGRI_mPanPan1871,129,371 - 71,131,649 (-)NCBI
Mhudiblu_PPA_v0876,286,433 - 76,288,711 (-)NCBI
PanPan1.1877,917,206 - 77,919,552 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003831331 (Get FASTA)   NCBI Sequence Viewer  
  XP_008954913 (Get FASTA)   NCBI Sequence Viewer  
  XP_024785719 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000012977
  ENSPPAP00000012977.1
  ENSPPAP00000012989.1
  ENSPPAP00000012990.1
Reference Protein Sequences
RefSeq Acc Id: XP_003831331   ⟸   XM_003831283
- Peptide Label: isoform X2
- UniProtKB: A0A2R9ABZ3 (UniProtKB/TrEMBL),   A0A2R9A6S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008954913   ⟸   XM_008956665
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A6S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024785719   ⟸   XM_024929951
- Peptide Label: isoform X3
- UniProtKB: A0A2R9A7X2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000012977   ⟸   ENSPPAT00000035645
RefSeq Acc Id: ENSPPAP00000012989   ⟸   ENSPPAT00000035657
RefSeq Acc Id: ENSPPAP00000012990   ⟸   ENSPPAT00000035658
Protein Domains
bHLH   Orange


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029647 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035645.1 UniProtKB/TrEMBL
  ENSPPAT00000035657.1 UniProtKB/TrEMBL
  ENSPPAT00000035658.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  6.10.250.980 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Orange_dom UniProtKB/TrEMBL
KEGG Report pps:100984313 UniProtKB/TrEMBL
NCBI Gene HEY1 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/TrEMBL
  HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 1 UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
Superfamily-SCOP Orange domain-like UniProtKB/TrEMBL
  SSF47459 UniProtKB/TrEMBL
UniProt A0A2R9A6S4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A7X2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ABZ3 ENTREZGENE, UniProtKB/TrEMBL